Motif ID: Pax2

Z-value: 0.883


Transcription factors associated with Pax2:

Gene SymbolEntrez IDGene Name
Pax2 ENSMUSG00000004231.9 Pax2



Activity profile for motif Pax2.

activity profile for motif Pax2


Sorted Z-values histogram for motif Pax2

Sorted Z-values for motif Pax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_82291370 1.307 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr17_+_26715644 1.264 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr6_+_17463927 1.226 ENSMUST00000115442.1
 Met
met proto-oncogene
chr18_+_34861200 1.183 ENSMUST00000165033.1
 Egr1
early growth response 1
chr5_-_124425572 1.169 ENSMUST00000168651.1
 Sbno1
sno, strawberry notch homolog 1 (Drosophila)
chr11_+_35769462 1.093 ENSMUST00000018990.7
 Pank3
pantothenate kinase 3
chr2_+_119897212 1.090 ENSMUST00000046717.6
ENSMUST00000110774.1
ENSMUST00000110773.2
ENSMUST00000079934.5
ENSMUST00000156510.1
 Mga




MAX gene associated




chr4_+_148039035 1.073 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr12_-_102878406 1.069 ENSMUST00000045652.6
 Btbd7
BTB (POZ) domain containing 7
chr2_+_48949495 1.034 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr10_+_111164794 1.024 ENSMUST00000105275.1
ENSMUST00000095310.1
 Osbpl8

oxysterol binding protein-like 8

chr16_+_77014069 0.998 ENSMUST00000023580.6
 Usp25
ubiquitin specific peptidase 25
chr4_+_148039097 0.986 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr16_+_94370786 0.937 ENSMUST00000147046.1
ENSMUST00000149885.1
ENSMUST00000127667.1
ENSMUST00000119131.1
ENSMUST00000145883.1
 Ttc3




tetratricopeptide repeat domain 3




chr16_-_45158183 0.864 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr11_-_120630126 0.861 ENSMUST00000106180.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr13_+_13590402 0.857 ENSMUST00000110559.1
 Lyst
lysosomal trafficking regulator
chr11_-_120630516 0.856 ENSMUST00000106181.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr16_-_45158624 0.845 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr2_+_126707319 0.820 ENSMUST00000028841.7
ENSMUST00000110416.2
 Usp8

ubiquitin specific peptidase 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0008643 carbohydrate transport(GO:0008643)
0.2 2.3 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.5 2.1 GO:0070829 heterochromatin maintenance(GO:0070829)
0.6 1.9 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.0 1.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 1.7 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.3 1.4 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.3 1.3 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.3 1.3 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 1.3 GO:0042117 monocyte activation(GO:0042117)
0.4 1.2 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 1.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.4 1.1 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.2 1.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.1 GO:0060746 parental behavior(GO:0060746)
0.3 1.0 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.3 1.0 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.2 1.0 GO:1905049 negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.1 1.0 GO:1904293 negative regulation of ERAD pathway(GO:1904293)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 1.3 GO:0005899 insulin receptor complex(GO:0005899)
0.2 1.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.3 GO:0000502 proteasome complex(GO:0000502)
0.1 1.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.2 1.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.0 GO:0010369 chromocenter(GO:0010369)
0.3 0.9 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.0 0.9 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
0.1 0.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.8 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.6 GO:0097422 tubular endosome(GO:0097422)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.7 2.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 1.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 1.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 1.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.0 GO:0032183 SUMO binding(GO:0032183)
0.0 1.0 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 1.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.0 GO:0070273 phosphatidylserine binding(GO:0001786) phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.7 GO:0004887 thyroid hormone receptor activity(GO:0004887)