Motif ID: Pax6

Z-value: 0.544


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.831.0e-06Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_95587691 3.376 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr10_+_26229707 2.692 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr8_-_57962564 1.840 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr16_+_4968936 1.375 ENSMUST00000090457.5
 4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr1_-_138619687 1.237 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr7_-_103843154 1.182 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr5_+_149265035 1.099 ENSMUST00000130144.1
ENSMUST00000071130.3
 Alox5ap

arachidonate 5-lipoxygenase activating protein

chr5_-_142906702 1.090 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr4_+_85205417 1.076 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr10_+_94550852 0.874 ENSMUST00000148910.1
ENSMUST00000117460.1
 Tmcc3

transmembrane and coiled coil domains 3

chr8_+_105860634 0.746 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr11_-_67965631 0.685 ENSMUST00000021287.5
ENSMUST00000126766.1
 Wdr16

WD repeat domain 16

chr15_+_84669565 0.619 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr12_-_45074457 0.593 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr1_+_156040909 0.591 ENSMUST00000065648.8
ENSMUST00000097526.2
 Tor1aip2

torsin A interacting protein 2

chr9_-_10904697 0.560 ENSMUST00000162484.1
 Cntn5
contactin 5
chr13_-_66905322 0.523 ENSMUST00000021993.4
 Uqcrb
ubiquinol-cytochrome c reductase binding protein
chr9_+_15239045 0.499 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr19_-_57118981 0.468 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr18_-_34373313 0.463 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chrX_+_36795642 0.443 ENSMUST00000016463.3
 Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr19_-_57118897 0.436 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr15_-_35938186 0.435 ENSMUST00000014457.8
 Cox6c
cytochrome c oxidase subunit VIc
chr5_+_123907175 0.432 ENSMUST00000023869.8
 Denr
density-regulated protein
chr3_-_89245005 0.417 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46
chr6_-_60829826 0.414 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr11_+_60699718 0.407 ENSMUST00000052346.3
 Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr4_+_155491353 0.404 ENSMUST00000165335.1
ENSMUST00000105616.3
ENSMUST00000030940.7
 Gnb1


guanine nucleotide binding protein (G protein), beta 1


chr6_-_113377376 0.363 ENSMUST00000043333.2
 Tada3
transcriptional adaptor 3
chr14_+_34170640 0.358 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr8_+_95825353 0.356 ENSMUST00000074053.4
 Gm10094
predicted gene 10094
chr11_+_60699758 0.339 ENSMUST00000108719.3
 Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr15_-_101850778 0.330 ENSMUST00000023790.3
 Krt1
keratin 1
chr9_+_64179289 0.321 ENSMUST00000034965.6
 Snapc5
small nuclear RNA activating complex, polypeptide 5
chr4_+_129820702 0.319 ENSMUST00000165853.1
 Ptp4a2
protein tyrosine phosphatase 4a2
chr3_-_89245159 0.319 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chrX_+_103422010 0.314 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr10_-_127030813 0.314 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr17_+_43016536 0.293 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr6_-_88045190 0.285 ENSMUST00000113596.1
ENSMUST00000113600.3
 Rab7

RAB7, member RAS oncogene family

chr16_-_52452654 0.261 ENSMUST00000168071.1
 Alcam
activated leukocyte cell adhesion molecule
chr4_-_3835595 0.257 ENSMUST00000138502.1
 Rps20
ribosomal protein S20
chr5_-_134639311 0.257 ENSMUST00000036125.8
 Eif4h
eukaryotic translation initiation factor 4H
chr15_-_35938009 0.246 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr2_+_163602294 0.238 ENSMUST00000171696.1
ENSMUST00000109408.3
 Ttpal

tocopherol (alpha) transfer protein-like

chr19_+_34290653 0.229 ENSMUST00000025691.5
ENSMUST00000112472.2
 Fas

Fas (TNF receptor superfamily member 6)

chr16_+_20498817 0.227 ENSMUST00000003320.6
 Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
chr1_-_38836090 0.211 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr17_-_43543639 0.204 ENSMUST00000178772.1
 Ankrd66
ankyrin repeat domain 66
chr4_-_139832920 0.196 ENSMUST00000174681.1
 Pax7
paired box gene 7
chr13_-_32781716 0.196 ENSMUST00000134352.1
ENSMUST00000057428.4
 Mylk4

myosin light chain kinase family, member 4

chr15_+_103272893 0.193 ENSMUST00000100162.3
 Copz1
coatomer protein complex, subunit zeta 1
chr15_+_6299797 0.189 ENSMUST00000159046.1
ENSMUST00000161040.1
 Dab2

disabled 2, mitogen-responsive phosphoprotein

chr9_+_92250039 0.179 ENSMUST00000093801.3
 Plscr1
phospholipid scramblase 1
chr17_+_29614800 0.156 ENSMUST00000162588.1
 Rnf8
ring finger protein 8
chr6_+_123229843 0.154 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr13_-_97760588 0.152 ENSMUST00000074072.3
 Gm10260
predicted gene 10260
chr13_+_66905415 0.148 ENSMUST00000099412.2
 Gm10767
predicted gene 10767
chr12_+_112976471 0.136 ENSMUST00000165079.1
ENSMUST00000002880.6
 Btbd6

BTB (POZ) domain containing 6

chr6_-_145048809 0.133 ENSMUST00000032402.5
 Bcat1
branched chain aminotransferase 1, cytosolic
chr7_-_86775808 0.129 ENSMUST00000107271.3
 Folh1
folate hydrolase 1
chr8_+_109614417 0.127 ENSMUST00000109242.1
ENSMUST00000057344.2
 Pkd1l3

polycystic kidney disease 1 like 3

chr17_+_34604262 0.123 ENSMUST00000174041.1
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr1_-_180813534 0.122 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr2_-_75981967 0.115 ENSMUST00000099994.3
 Ttc30a1
tetratricopeptide repeat domain 30A1
chr5_+_90903864 0.100 ENSMUST00000075433.6
 Cxcl2
chemokine (C-X-C motif) ligand 2
chr9_-_62811592 0.084 ENSMUST00000034775.8
 Fem1b
feminization 1 homolog b (C. elegans)
chr1_-_180813591 0.084 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
 H3f3a


H3 histone, family 3A


chr14_-_43819639 0.083 ENSMUST00000100691.3
 Ear1
eosinophil-associated, ribonuclease A family, member 1
chr2_+_105904629 0.083 ENSMUST00000037499.5
 Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr6_-_122856151 0.081 ENSMUST00000042081.8
 C3ar1
complement component 3a receptor 1
chr7_-_86775860 0.067 ENSMUST00000001824.5
 Folh1
folate hydrolase 1
chr10_-_127030789 0.065 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial

chr7_+_12897800 0.061 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr11_+_67966442 0.046 ENSMUST00000021286.4
ENSMUST00000108675.1
 Stx8

syntaxin 8

chr15_+_6299781 0.044 ENSMUST00000078019.6
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chr11_+_45852031 0.039 ENSMUST00000109261.3
ENSMUST00000109260.1
 Clint1

clathrin interactor 1

chr9_+_50775347 0.027 ENSMUST00000159576.1
 Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr8_-_72475212 0.027 ENSMUST00000079510.4
 Cherp
calcium homeostasis endoplasmic reticulum protein
chrX_+_73214333 0.027 ENSMUST00000156188.1
ENSMUST00000069077.3
ENSMUST00000069103.4
ENSMUST00000114506.1
ENSMUST00000081827.3
 Xlr4b




X-linked lymphocyte-regulated 4B




chr5_+_112255813 0.014 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
 Crybb1


crystallin, beta B1


chr7_-_80901220 0.002 ENSMUST00000146402.1
ENSMUST00000026816.8
 Wdr73

WD repeat domain 73


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.4 1.1 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.2 1.2 GO:0015671 oxygen transport(GO:0015671)
0.1 0.4 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.1 0.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.1 1.1 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.4 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 0.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.7 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.1 0.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.4 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 0.4 GO:0032790 ribosome disassembly(GO:0032790)
0.1 0.2 GO:0010911 regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.2 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.6 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 1.2 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.3 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 1.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.7 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.0 0.2 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.2 GO:0014002 astrocyte development(GO:0014002)
0.0 0.6 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005833 hemoglobin complex(GO:0005833)
0.1 3.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.1 GO:0070688 MLL5-L complex(GO:0070688)
0.1 0.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.4 GO:0071817 MMXD complex(GO:0071817)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.3 1.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.3 1.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 1.1 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.4 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.8 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)