Motif ID: Pax6

Z-value: 0.544


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.831.0e-06Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Showing 1 to 20 of 82 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_95587691 3.376 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr10_+_26229707 2.692 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr8_-_57962564 1.840 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr16_+_4968936 1.375 ENSMUST00000090457.5
 4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr1_-_138619687 1.237 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr7_-_103843154 1.182 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr5_+_149265035 1.099 ENSMUST00000130144.1
ENSMUST00000071130.3
 Alox5ap

arachidonate 5-lipoxygenase activating protein

chr5_-_142906702 1.090 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr4_+_85205417 1.076 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr10_+_94550852 0.874 ENSMUST00000148910.1
ENSMUST00000117460.1
 Tmcc3

transmembrane and coiled coil domains 3

chr8_+_105860634 0.746 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr11_-_67965631 0.685 ENSMUST00000021287.5
ENSMUST00000126766.1
 Wdr16

WD repeat domain 16

chr15_+_84669565 0.619 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr12_-_45074457 0.593 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr1_+_156040909 0.591 ENSMUST00000065648.8
ENSMUST00000097526.2
 Tor1aip2

torsin A interacting protein 2

chr9_-_10904697 0.560 ENSMUST00000162484.1
 Cntn5
contactin 5
chr13_-_66905322 0.523 ENSMUST00000021993.4
 Uqcrb
ubiquinol-cytochrome c reductase binding protein
chr9_+_15239045 0.499 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr19_-_57118981 0.468 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr18_-_34373313 0.463 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.2 1.2 GO:0015671 oxygen transport(GO:0015671)
0.0 1.2 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.4 1.1 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.1 1.1 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 1.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.7 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.7 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.1 0.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.6 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.6 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.1 0.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.4 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.1 0.4 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 0.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.4 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 0.4 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.2 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.1 GO:0070688 MLL5-L complex(GO:0070688)
0.1 0.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.1 0.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.4 GO:0071817 MMXD complex(GO:0071817)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.8 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.3 1.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.3 1.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 1.1 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.4 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)