Motif ID: Pbx2

Z-value: 0.538


Transcription factors associated with Pbx2:

Gene SymbolEntrez IDGene Name
Pbx2 ENSMUSG00000034673.8 Pbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx2mm10_v2_chr17_+_34593388_34593417-0.702.2e-04Click!


Activity profile for motif Pbx2.

activity profile for motif Pbx2


Sorted Z-values histogram for motif Pbx2

Sorted Z-values for motif Pbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56972437 1.476 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr15_-_66812593 1.342 ENSMUST00000100572.3
 Sla
src-like adaptor
chr3_+_121953213 1.273 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr11_+_3330401 1.153 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr7_-_43505926 0.959 ENSMUST00000013497.1
ENSMUST00000163619.1
 4931406B18Rik

RIKEN cDNA 4931406B18 gene

chr17_+_78508063 0.921 ENSMUST00000024880.9
 Vit
vitrin
chr9_-_42399709 0.908 ENSMUST00000160940.1
 Tecta
tectorin alpha
chr11_+_3330781 0.888 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr11_+_97685794 0.832 ENSMUST00000107584.1
ENSMUST00000107585.2
 Cisd3

CDGSH iron sulfur domain 3

chr6_+_8259379 0.711 ENSMUST00000162034.1
ENSMUST00000160705.1
ENSMUST00000159433.1
 Gm16039


predicted gene 16039


chrM_+_11734 0.711 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr9_-_89705017 0.683 ENSMUST00000058488.6
 Tmed3
transmembrane emp24 domain containing 3
chr16_-_37384915 0.654 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr2_-_104257400 0.639 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr2_+_106695594 0.639 ENSMUST00000016530.7
 Mpped2
metallophosphoesterase domain containing 2
chr12_+_108334341 0.618 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr5_+_106609098 0.606 ENSMUST00000167618.1
 Gm17304
predicted gene, 17304
chr9_-_54661870 0.597 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr8_+_72646679 0.589 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr2_+_128967383 0.582 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 1.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 1.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 1.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.7 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 0.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.6 GO:0006298 mismatch repair(GO:0006298)
0.1 0.5 GO:0032790 ribosome disassembly(GO:0032790)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0006547 histidine metabolic process(GO:0006547)
0.1 0.4 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.0 0.4 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.4 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.4 GO:0001553 luteinization(GO:0001553)
0.1 0.3 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.3 GO:2000598 regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.1 0.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 0.3 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.2 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.6 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.4 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) NADPH:sulfur oxidoreductase activity(GO:0043914) epoxyqueuosine reductase activity(GO:0052693)
0.1 0.3 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)