Motif ID: Pbx2
Z-value: 0.538
Transcription factors associated with Pbx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pbx2 | ENSMUSG00000034673.8 | Pbx2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pbx2 | mm10_v2_chr17_+_34593388_34593417 | -0.70 | 2.2e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.0 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.1 | 0.4 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.3 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
| 0.1 | 1.5 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.1 | 0.4 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.1 | 0.3 | GO:2000598 | regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599) |
| 0.1 | 0.3 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 0.2 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 0.3 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304) |
| 0.1 | 0.5 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 0.4 | GO:1902847 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) |
| 0.1 | 0.6 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 0.2 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.0 | 0.2 | GO:0002035 | brain renin-angiotensin system(GO:0002035) |
| 0.0 | 0.4 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 0.1 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.0 | 0.3 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.0 | 0.2 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 0.0 | 1.2 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 0.2 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.0 | 0.4 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.4 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 0.1 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.0 | 0.6 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.2 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.0 | 0.1 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) phosphate ion transmembrane transport(GO:0035435) |
| 0.0 | 0.4 | GO:0001553 | luteinization(GO:0001553) |
| 0.0 | 1.1 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.1 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 0.0 | 0.7 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.3 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 0.3 | GO:0006098 | pentose-phosphate shunt(GO:0006098) |
| 0.0 | 0.7 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.2 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.0 | 0.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.1 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 0.1 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
| 0.0 | 0.0 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.0 | 0.1 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 0.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418) |
| 0.1 | 0.2 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.1 | 0.8 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.7 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.1 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 1.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.8 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.1 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.1 | 0.4 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.1 | 1.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 0.3 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.1 | 0.3 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 0.3 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 0.3 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 0.3 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 0.4 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.2 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.2 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.0 | 1.0 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 1.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.2 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.0 | 0.1 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
| 0.0 | 0.1 | GO:0008410 | CoA-transferase activity(GO:0008410) |
| 0.0 | 0.6 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.4 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.1 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.0 | 0.1 | GO:0070636 | purine-specific mismatch base pair DNA N-glycosylase activity(GO:0000701) single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694) |
| 0.0 | 0.1 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.0 | 0.1 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.0 | 0.4 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) NADPH:sulfur oxidoreductase activity(GO:0043914) epoxyqueuosine reductase activity(GO:0052693) |
| 0.0 | 0.2 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.0 | 0.6 | GO:0044824 | integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824) |
| 0.0 | 0.6 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 1.1 | GO:0019905 | syntaxin binding(GO:0019905) |
