Motif ID: Pitx1
Z-value: 0.701
Transcription factors associated with Pitx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pitx1 | ENSMUSG00000021506.7 | Pitx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0043696 | dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) |
| 0.6 | 1.9 | GO:1904049 | regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.4 | 4.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.3 | 1.5 | GO:0060447 | bud outgrowth involved in lung branching(GO:0060447) |
| 0.3 | 0.8 | GO:0072554 | blood vessel lumenization(GO:0072554) |
| 0.2 | 0.5 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980) |
| 0.2 | 0.9 | GO:0032911 | nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.2 | 0.5 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.1 | 0.4 | GO:0097461 | ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) |
| 0.1 | 0.8 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 0.4 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.1 | 0.3 | GO:1902358 | sulfate transmembrane transport(GO:1902358) |
| 0.1 | 0.3 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.1 | 0.8 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.1 | 0.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 0.5 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
| 0.1 | 0.7 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.1 | 1.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.4 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.1 | 0.4 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.1 | 0.4 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.1 | 0.4 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.1 | 0.4 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 0.4 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.1 | 0.4 | GO:0003383 | apical constriction(GO:0003383) |
| 0.1 | 0.5 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
| 0.1 | 0.3 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 0.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.3 | GO:0030242 | pexophagy(GO:0030242) |
| 0.1 | 0.2 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.4 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.0 | 1.2 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.0 | 0.2 | GO:0048143 | astrocyte activation(GO:0048143) |
| 0.0 | 1.7 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.1 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.0 | 0.1 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
| 0.0 | 0.1 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.0 | 0.3 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.0 | 0.2 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.1 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 0.0 | 0.2 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 0.2 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.0 | 0.3 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.0 | 0.3 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.2 | GO:0060059 | regulation of protein heterodimerization activity(GO:0043497) embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.0 | 1.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.2 | GO:0003093 | regulation of glomerular filtration(GO:0003093) |
| 0.0 | 0.3 | GO:2000678 | negative regulation of transcription regulatory region DNA binding(GO:2000678) |
| 0.0 | 0.5 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.0 | 0.1 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.0 | 0.5 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.0 | 0.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 1.2 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.2 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.0 | 0.1 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.0 | 0.3 | GO:0007614 | short-term memory(GO:0007614) |
| 0.0 | 1.1 | GO:0007338 | single fertilization(GO:0007338) |
| 0.0 | 0.0 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.0 | 0.3 | GO:0072673 | lamellipodium morphogenesis(GO:0072673) |
| 0.0 | 0.2 | GO:0007097 | nuclear migration(GO:0007097) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.4 | 1.9 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.1 | 0.4 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.1 | 1.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.5 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.1 | 0.8 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 0.4 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.1 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 0.2 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 0.9 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.7 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.5 | GO:0030312 | external encapsulating structure(GO:0030312) |
| 0.0 | 0.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.1 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.0 | 2.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.0 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.2 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.0 | 0.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 0.3 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.3 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.2 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.1 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 0.2 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.3 | 1.2 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.3 | 1.5 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 0.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.2 | 0.7 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.2 | 0.6 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.2 | 0.5 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.1 | 0.4 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 0.9 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 0.4 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.1 | 0.4 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.1 | 0.9 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.2 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 0.8 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 0.5 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
| 0.1 | 1.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.4 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.1 | 0.8 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 0.2 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.1 | 0.5 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.1 | 0.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 2.1 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.4 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.0 | 0.1 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.0 | 0.5 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.0 | 1.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 1.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.5 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.4 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.0 | 0.6 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.1 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.0 | 0.3 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 0.3 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.5 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.8 | GO:0034930 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131) |
| 0.0 | 0.5 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.0 | 0.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 1.1 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.2 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.0 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
