Motif ID: Pitx1

Z-value: 0.701


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 198 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 1.683 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_-_64046925 1.525 ENSMUST00000107377.3
 Tnc
tenascin C
chr13_-_97747399 1.515 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr4_+_144893077 1.439 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_-_15879844 1.288 ENSMUST00000172758.1
ENSMUST00000044434.6
 Crx

cone-rod homeobox containing gene

chr4_+_144893127 1.278 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr17_+_75005523 1.240 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr15_+_18818895 1.210 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr1_-_155232710 1.174 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr5_+_3343893 1.159 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr3_-_84270782 1.080 ENSMUST00000054990.4
 Trim2
tripartite motif-containing 2
chr13_-_97747373 0.998 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr5_+_3344194 0.934 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chrX_+_169879596 0.930 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr7_-_80403315 0.872 ENSMUST00000147150.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr6_+_4902913 0.859 ENSMUST00000175889.1
ENSMUST00000168998.2
 Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr6_-_93913678 0.826 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_+_102658640 0.797 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_+_64588112 0.787 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr18_-_15718046 0.782 ENSMUST00000053017.6
 Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.4 GO:0042572 retinol metabolic process(GO:0042572)
0.7 2.1 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.6 1.9 GO:1904049 regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.0 1.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.3 1.5 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.0 1.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 1.2 GO:0007601 visual perception(GO:0007601)
0.0 1.1 GO:0007338 single fertilization(GO:0007338)
0.1 1.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 0.9 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.3 0.8 GO:0072554 blood vessel lumenization(GO:0072554)
0.1 0.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.7 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.5 GO:0016191 synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.2 0.5 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.5 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 1.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 1.5 GO:0005614 interstitial matrix(GO:0005614)
0.4 1.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.8 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.7 GO:0010369 chromocenter(GO:0010369)
0.1 0.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.5 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 2.1 GO:0030332 cyclin binding(GO:0030332)
0.1 1.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.5 GO:0045545 syndecan binding(GO:0045545)
0.3 1.2 GO:0050436 microfibril binding(GO:0050436)
0.1 1.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.1 GO:0017022 myosin binding(GO:0017022)
0.0 1.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 0.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.8 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.2 0.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 0.5 GO:0004568 chitinase activity(GO:0004568)
0.1 0.5 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)