Motif ID: Pitx2_Otx2

Z-value: 1.446

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pitx2mm10_v2_chr3_+_129199960_129199975-0.738.0e-05Click!
Otx2mm10_v2_chr14_-_48662740_48662872-0.262.2e-01Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_137410721 4.107 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr7_-_34812677 3.261 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr17_-_35188427 3.155 ENSMUST00000097336.4
 Lst1
leukocyte specific transcript 1
chrX_-_61185558 2.551 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr7_-_75782080 2.506 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr6_-_88898664 2.504 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr11_-_106998483 2.372 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr15_+_99006056 2.333 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr11_+_101448403 2.249 ENSMUST00000010502.6
 Ifi35
interferon-induced protein 35
chr14_-_70630149 2.246 ENSMUST00000022694.9
 Dmtn
dematin actin binding protein
chr6_+_34354119 2.243 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr17_+_6430112 2.163 ENSMUST00000179569.1
 Dynlt1b
dynein light chain Tctex-type 1B
chr2_-_118256929 2.150 ENSMUST00000028820.6
ENSMUST00000028821.3
 Fsip1

fibrous sheath-interacting protein 1

chr13_-_66852017 2.148 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr19_-_41896132 2.131 ENSMUST00000038677.3
 Rrp12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr8_-_71511762 2.082 ENSMUST00000048452.4
 Plvap
plasmalemma vesicle associated protein
chr7_+_45163915 2.022 ENSMUST00000085374.5
 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr4_+_155704789 1.952 ENSMUST00000030905.2
 Ssu72
Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
chr5_+_24985840 1.902 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr2_+_164562579 1.827 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 369 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 4.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.8 4.1 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.1 3.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 3.5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.2 3.3 GO:0016486 peptide hormone processing(GO:0016486)
0.0 2.9 GO:0008360 regulation of cell shape(GO:0008360)
0.1 2.8 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 2.7 GO:0045760 positive regulation of action potential(GO:0045760)
0.1 2.6 GO:0006778 porphyrin-containing compound metabolic process(GO:0006778)
0.2 2.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 2.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.2 2.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 2.3 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.7 2.2 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.7 2.2 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.2 2.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 2.1 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.7 2.0 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 7.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 6.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 5.5 GO:0005643 nuclear pore(GO:0005643)
0.1 5.2 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 4.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 4.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 4.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 3.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 2.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 2.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.6 2.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 2.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 2.1 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 2.1 GO:0005840 ribosome(GO:0005840)
0.5 2.0 GO:0001533 cornified envelope(GO:0001533)
0.1 2.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 1.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 252 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 5.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 5.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 4.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 3.7 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.1 3.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 3.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 3.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.9 GO:0030507 spectrin binding(GO:0030507)
0.3 2.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.3 GO:0003774 motor activity(GO:0003774)
0.4 2.2 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.2 2.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 2.0 GO:0005436 sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319)
0.2 2.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 2.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)