Motif ID: Pitx3

Z-value: 0.828


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_62899118 3.246 ENSMUST00000174189.1
 Tet1
tet methylcytosine dioxygenase 1
chr1_-_186705980 2.557 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr3_+_86070915 2.155 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr7_-_79386943 2.041 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr16_+_17276291 1.984 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chrX_+_142226765 1.781 ENSMUST00000112916.2
 Nxt2
nuclear transport factor 2-like export factor 2
chr4_-_32923455 1.544 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr13_-_12464925 1.445 ENSMUST00000124888.1
 Lgals8
lectin, galactose binding, soluble 8
chr5_+_3571664 1.395 ENSMUST00000008451.5
 1700109H08Rik
RIKEN cDNA 1700109H08 gene
chr5_+_122643878 1.395 ENSMUST00000100737.3
ENSMUST00000121489.1
ENSMUST00000031425.8
ENSMUST00000086247.5
 P2rx7



purinergic receptor P2X, ligand-gated ion channel, 7



chr10_+_128908907 1.373 ENSMUST00000105229.1
 Cd63
CD63 antigen
chrX_-_103623648 1.335 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr9_-_62070606 1.327 ENSMUST00000034785.7
 Glce
glucuronyl C5-epimerase
chr8_+_65967157 1.318 ENSMUST00000072482.6
 March1
membrane-associated ring finger (C3HC4) 1
chr9_+_118506226 1.307 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr19_+_7494033 1.265 ENSMUST00000170373.1
 Atl3
atlastin GTPase 3
chr11_-_100770926 1.250 ENSMUST00000139341.1
ENSMUST00000017891.7
 Ghdc

GH3 domain containing

chr13_-_77131276 1.247 ENSMUST00000159300.1
 Ankrd32
ankyrin repeat domain 32
chr2_-_132578128 1.241 ENSMUST00000028822.7
 Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr9_+_22454290 1.179 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.4 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 3.3 GO:0001824 blastocyst development(GO:0001824)
0.6 3.2 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.9 2.6 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1 2.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 2.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 2.1 GO:0007601 visual perception(GO:0007601)
0.4 2.0 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2 1.6 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.5 1.4 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) interleukin-1 alpha secretion(GO:0050703)
0.3 1.4 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.2 1.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 1.3 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 1.3 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 1.3 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.3 1.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.3 1.2 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.2 1.1 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 1.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 1.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0005604 basement membrane(GO:0005604)
0.7 2.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.3 1.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 1.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 1.2 GO:0000802 transverse filament(GO:0000802)
0.3 1.2 GO:0031230 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.2 1.0 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.9 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.2 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 0.8 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.1 0.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 0.7 GO:0031209 SCAR complex(GO:0031209)
0.1 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.4 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.5 3.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.6 2.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.6 2.2 GO:0050436 microfibril binding(GO:0050436)
0.1 2.2 GO:0070064 proline-rich region binding(GO:0070064)
0.3 2.0 GO:0019841 retinol binding(GO:0019841)
0.3 1.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.3 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.2 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.4 1.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 1.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 1.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.0 GO:0016937 short-branched-chain-acyl-CoA dehydrogenase activity(GO:0016937)
0.1 1.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 0.9 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 0.9 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.8 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)