Motif ID: Pknox2_Pknox1

Z-value: 0.924

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox2mm10_v2_chr9_-_37147257_371473230.657.1e-04Click!
Pknox1mm10_v2_chr17_+_31564749_31564854-0.462.6e-02Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_113758638 6.324 ENSMUST00000099575.3
 Grem1
gremlin 1
chr5_-_134747241 3.803 ENSMUST00000015138.9
 Eln
elastin
chr16_-_43979050 2.501 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr15_-_100599864 2.275 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr5_-_109558957 2.265 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr2_-_31141802 2.132 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
 Fnbp1






formin binding protein 1






chr7_-_131410325 1.919 ENSMUST00000154602.1
 Ikzf5
IKAROS family zinc finger 5
chr1_-_52727457 1.875 ENSMUST00000156876.1
ENSMUST00000087701.3
 Mfsd6

major facilitator superfamily domain containing 6

chr2_-_116065047 1.820 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2

chr18_+_49832622 1.810 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr7_+_112225856 1.741 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr15_+_32920723 1.726 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr1_+_194619815 1.684 ENSMUST00000027952.5
 Plxna2
plexin A2
chr3_-_84270782 1.661 ENSMUST00000054990.4
 Trim2
tripartite motif-containing 2
chr2_-_34913976 1.602 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr7_-_131410495 1.566 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr2_-_31142002 1.537 ENSMUST00000113560.1
ENSMUST00000113564.2
ENSMUST00000113562.2
 Fnbp1


formin binding protein 1


chr5_-_138619653 1.443 ENSMUST00000129832.1
 Zfp68
zinc finger protein 68
chr8_-_111522073 1.418 ENSMUST00000034437.6
ENSMUST00000038193.7
 Wdr59

WD repeat domain 59

chr11_+_78826575 1.410 ENSMUST00000147875.2
ENSMUST00000141321.1
 Lyrm9

LYR motif containing 9


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 6.3 GO:1901228 regulation of osteoclast proliferation(GO:0090289) negative regulation of bone mineralization involved in bone maturation(GO:1900158) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 3.7 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.4 2.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 2.5 GO:0018345 protein palmitoylation(GO:0018345)
0.4 2.3 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.0 2.3 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.3 2.2 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0 1.8 GO:0008542 visual learning(GO:0008542)
0.4 1.7 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 1.7 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 1.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 1.7 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.2 1.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 1.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 1.4 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.3 1.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.2 1.1 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.0 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.9 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.8 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 GO:0009986 cell surface(GO:0009986)
1.3 3.8 GO:0071953 elastic fiber(GO:0071953)
0.0 3.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 1.9 GO:0061700 GATOR2 complex(GO:0061700)
0.2 1.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.3 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 6.3 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 3.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6 2.6 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 2.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 2.3 GO:0020037 heme binding(GO:0020037)
0.0 2.3 GO:0005125 cytokine activity(GO:0005125)
0.1 2.2 GO:0001221 transcription cofactor binding(GO:0001221)
0.4 1.7 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.2 1.7 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.1 1.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.7 GO:0017022 myosin binding(GO:0017022)
0.0 1.6 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 1.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.0 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.1 0.9 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)