Motif ID: Plag1

Z-value: 0.673


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_3938401-0.415.1e-02Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 2.297 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr10_-_102490418 1.449 ENSMUST00000020040.3
 Nts
neurotensin
chr15_-_66801577 1.202 ENSMUST00000168589.1
 Sla
src-like adaptor
chr17_-_87797994 1.201 ENSMUST00000055221.7
 Kcnk12
potassium channel, subfamily K, member 12
chr4_-_129121699 1.197 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr5_-_89883321 1.178 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr11_-_69369377 1.095 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr18_-_58209926 1.067 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr4_-_133498538 1.015 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr5_+_117841839 0.864 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr11_-_95587691 0.852 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr1_+_75382114 0.849 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr11_+_77930800 0.847 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr18_-_38211957 0.815 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr5_-_37717122 0.797 ENSMUST00000094836.4
 Stk32b
serine/threonine kinase 32B
chr4_-_129121889 0.794 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr4_-_129121234 0.791 ENSMUST00000030572.3
 Hpca
hippocalcin
chr3_+_117575268 0.747 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr19_-_42431778 0.733 ENSMUST00000048630.6
 Crtac1
cartilage acidic protein 1
chr14_-_49525840 0.722 ENSMUST00000138884.1
ENSMUST00000074368.4
ENSMUST00000123534.1
 Slc35f4


solute carrier family 35, member F4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.8 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.1 GO:0021695 cerebellar cortex development(GO:0021695)
0.1 1.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 1.4 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.0 1.4 GO:0008542 visual learning(GO:0008542)
0.2 1.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 1.1 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.1 1.1 GO:0021681 cerebellar granular layer development(GO:0021681)
0.3 0.9 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.2 0.9 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 0.8 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.8 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.0 0.8 GO:0033198 response to ATP(GO:0033198)
0.2 0.7 GO:0016115 terpenoid catabolic process(GO:0016115)
0.1 0.7 GO:0015816 glycine transport(GO:0015816)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 2.3 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 1.1 GO:0001527 microfibril(GO:0001527)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.0 GO:0031045 dense core granule(GO:0031045)
0.2 0.9 GO:0008091 spectrin(GO:0008091)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.8 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.2 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.2 0.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.7 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 0.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.5 1.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 1.3 GO:0019841 retinol binding(GO:0019841)
0.2 1.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.1 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.9 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.8 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.8 GO:0030546 receptor activator activity(GO:0030546)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.7 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.7 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)