Motif ID: Prox1

Z-value: 0.504


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.387.6e-02Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_99416397 0.858 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chr12_-_83487708 0.730 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr8_+_99416585 0.648 ENSMUST00000064349.5
 A330008L17Rik
RIKEN cDNA A330008L17 gene
chr15_-_80014808 0.609 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr4_+_130913120 0.577 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr1_-_169747634 0.533 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr7_-_127448993 0.507 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr7_-_127449109 0.506 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689
chr6_-_131388417 0.476 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr5_-_37824580 0.460 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr10_-_81025521 0.416 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr2_-_92459709 0.395 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chr4_+_130913264 0.395 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr4_-_68954351 0.391 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr4_-_131821516 0.389 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr6_+_58640536 0.358 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr7_+_127777095 0.331 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr10_-_81496313 0.314 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr18_-_20682963 0.299 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chr6_+_29361410 0.290 ENSMUST00000156163.1
 Calu
calumenin
chr2_-_168734236 0.288 ENSMUST00000109175.2
 Atp9a
ATPase, class II, type 9A
chr10_-_81496329 0.287 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr5_+_139252343 0.277 ENSMUST00000130326.1
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr5_+_124112297 0.267 ENSMUST00000024470.6
ENSMUST00000119269.1
 Ogfod2

2-oxoglutarate and iron-dependent oxygenase domain containing 2

chr4_+_140701466 0.266 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr2_+_34406949 0.259 ENSMUST00000040459.4
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr2_+_136891501 0.257 ENSMUST00000141463.1
 Slx4ip
SLX4 interacting protein
chr7_-_19458494 0.255 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chrX_-_73966329 0.249 ENSMUST00000114372.2
ENSMUST00000033761.6
 Hcfc1

host cell factor C1

chr17_+_37045980 0.248 ENSMUST00000174456.1
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr9_-_106247730 0.240 ENSMUST00000112524.2
ENSMUST00000074082.6
 Alas1

aminolevulinic acid synthase 1

chr5_+_139211934 0.240 ENSMUST00000148772.1
ENSMUST00000110882.1
 Sun1

Sad1 and UNC84 domain containing 1

chr19_+_46056539 0.233 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
 Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr17_-_70924958 0.229 ENSMUST00000180468.1
 Gm26510
predicted gene, 26510
chr2_+_34406845 0.229 ENSMUST00000124443.1
ENSMUST00000113124.1
 Mapkap1

mitogen-activated protein kinase associated protein 1

chr2_+_34406882 0.223 ENSMUST00000113123.1
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr4_+_133176336 0.204 ENSMUST00000105912.1
 Wasf2
WAS protein family, member 2
chr11_+_19924403 0.204 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr17_-_34959232 0.200 ENSMUST00000165202.1
ENSMUST00000172753.1
 Hspa1b

heat shock protein 1B

chr17_+_27839974 0.192 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr2_+_36230426 0.191 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr17_+_37045963 0.191 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr8_-_70476911 0.172 ENSMUST00000066597.5
ENSMUST00000166976.1
 Klhl26

kelch-like 26

chr10_-_81025406 0.172 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr8_+_85080939 0.169 ENSMUST00000140621.1
 BC056474
cDNA sequence BC056474
chr2_-_26910569 0.153 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
 Med22


mediator complex subunit 22


chr18_-_67245818 0.148 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr11_+_120784257 0.138 ENSMUST00000100134.3
 Gps1
G protein pathway suppressor 1
chr5_+_139252314 0.131 ENSMUST00000026976.5
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr11_-_115933464 0.129 ENSMUST00000021097.3
 Recql5
RecQ protein-like 5
chr19_-_15924560 0.126 ENSMUST00000162053.1
 Psat1
phosphoserine aminotransferase 1
chr11_-_120784183 0.125 ENSMUST00000026156.7
 Rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr19_+_41911851 0.123 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr4_-_133967235 0.121 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr17_-_35516780 0.117 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19


chr12_+_40222758 0.117 ENSMUST00000038121.4
 Gm7008
predicted gene 7008
chr9_-_110117303 0.103 ENSMUST00000136969.1
 Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr8_-_85080652 0.101 ENSMUST00000152785.1
 Wdr83
WD repeat domain containing 83
chr17_-_34972124 0.098 ENSMUST00000087328.2
ENSMUST00000179128.1
 Hspa1a

heat shock protein 1A

chr2_-_167062981 0.098 ENSMUST00000048988.7
 Znfx1
zinc finger, NFX1-type containing 1
chr5_-_138187177 0.086 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr17_+_24426676 0.085 ENSMUST00000024946.5
 Eci1
enoyl-Coenzyme A delta isomerase 1
chr19_-_43524462 0.082 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr1_-_160792908 0.081 ENSMUST00000028049.7
 Rabgap1l
RAB GTPase activating protein 1-like
chr17_-_83514311 0.080 ENSMUST00000167741.1
ENSMUST00000025095.7
 Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr2_+_27009936 0.079 ENSMUST00000133807.1
 Cacfd1
calcium channel flower domain containing 1
chr7_+_24081888 0.078 ENSMUST00000068975.3
 Zfp180
zinc finger protein 180
chr11_+_4986824 0.073 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr8_-_85080679 0.073 ENSMUST00000093357.5
 Wdr83
WD repeat domain containing 83
chr19_+_46152505 0.069 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr11_+_19924354 0.067 ENSMUST00000093299.6
 Spred2
sprouty-related, EVH1 domain containing 2
chr4_+_42950369 0.067 ENSMUST00000084662.5
 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr8_+_31111816 0.066 ENSMUST00000046941.7
 Rnf122
ring finger protein 122
chrX_-_43274786 0.064 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr15_-_89149557 0.058 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr7_-_126861648 0.057 ENSMUST00000129812.1
ENSMUST00000106342.1
 Ino80e

INO80 complex subunit E

chr15_-_86186136 0.046 ENSMUST00000044332.9
 Cerk
ceramide kinase
chr9_+_104569671 0.045 ENSMUST00000057742.8
 Cpne4
copine IV
chr7_-_80947499 0.035 ENSMUST00000120285.1
 Sec11a
SEC11 homolog A (S. cerevisiae)
chr7_+_28716846 0.017 ENSMUST00000108279.2
 Fbxo17
F-box protein 17
chr11_-_115612878 0.015 ENSMUST00000106506.1
 Mif4gd
MIF4G domain containing
chr11_-_115612940 0.012 ENSMUST00000021087.7
 Mif4gd
MIF4G domain containing
chr2_+_27009926 0.012 ENSMUST00000114005.2
ENSMUST00000114004.1
ENSMUST00000114006.1
ENSMUST00000114007.1
 Cacfd1



calcium channel flower domain containing 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 0.5 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 0.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.4 GO:0046618 drug export(GO:0046618)
0.1 0.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.3 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.1 0.4 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.4 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.1 0.2 GO:0019042 viral latency(GO:0019042)
0.1 0.4 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.4 GO:0042711 maternal behavior(GO:0042711)
0.0 0.9 GO:0009409 response to cold(GO:0009409)
0.0 0.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.6 GO:0031648 protein destabilization(GO:0031648)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.9 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.4 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.7 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.3 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.1 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)