Motif ID: Prox1

Z-value: 0.504


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.387.6e-02Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_99416397 0.858 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chr12_-_83487708 0.730 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr8_+_99416585 0.648 ENSMUST00000064349.5
 A330008L17Rik
RIKEN cDNA A330008L17 gene
chr15_-_80014808 0.609 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr4_+_130913120 0.577 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr1_-_169747634 0.533 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr7_-_127448993 0.507 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr7_-_127449109 0.506 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689
chr6_-_131388417 0.476 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr5_-_37824580 0.460 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr10_-_81025521 0.416 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr2_-_92459709 0.395 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chr4_+_130913264 0.395 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr4_-_68954351 0.391 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr4_-_131821516 0.389 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr6_+_58640536 0.358 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr7_+_127777095 0.331 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr10_-_81496313 0.314 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr18_-_20682963 0.299 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chr6_+_29361410 0.290 ENSMUST00000156163.1
 Calu
calumenin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0009409 response to cold(GO:0009409)
0.0 0.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.2 0.6 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0 0.6 GO:0031648 protein destabilization(GO:0031648)
0.2 0.5 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 0.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.4 GO:0046618 drug export(GO:0046618)
0.1 0.4 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.4 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.1 0.4 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.4 GO:0042711 maternal behavior(GO:0042711)
0.1 0.3 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.2 GO:0019042 viral latency(GO:0019042)
0.0 0.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.7 GO:0071565 nBAF complex(GO:0071565)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.4 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.3 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)