Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.905

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx1mm10_v2_chr1_-_163313661_1633137100.631.1e-03Click!
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.602.5e-03Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_79386943 7.546 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr14_+_80000292 4.242 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr3_+_86070915 3.943 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr14_-_101609033 3.490 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr15_-_8710734 2.993 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrM_+_11734 2.897 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr5_-_62766153 2.708 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_160619971 2.572 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr2_+_116067213 2.425 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr3_-_49757257 2.351 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr15_-_8710409 2.032 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_37459327 2.009 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr1_+_58210397 1.995 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr11_-_117873433 1.952 ENSMUST00000033230.7
 Tha1
threonine aldolase 1
chr4_-_87806296 1.948 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr3_-_59220150 1.851 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr1_-_56969864 1.770 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr4_-_32923455 1.763 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr4_-_87806276 1.747 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr5_-_124095749 1.583 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0007601 visual perception(GO:0007601)
0.3 6.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.3 5.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 4.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.4 3.7 GO:0007379 segment specification(GO:0007379)
0.4 3.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 3.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 3.1 GO:0002076 osteoblast development(GO:0002076)
0.1 2.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 2.2 GO:0006566 threonine metabolic process(GO:0006566)
0.5 2.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 2.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 2.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.7 2.0 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 2.0 GO:0002488 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489)
0.6 1.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 1.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.4 1.8 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.8 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.0 GO:0043205 fibril(GO:0043205)
0.3 4.2 GO:0042581 specific granule(GO:0042581)
0.0 3.8 GO:0070469 respiratory chain(GO:0070469)
0.1 3.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 3.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 2.3 GO:0005901 caveola(GO:0005901)
0.1 2.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.5 1.6 GO:0005584 collagen type I trimer(GO:0005584)
0.0 1.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.2 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.9 GO:0005675 holo TFIIH complex(GO:0005675)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 7.5 GO:0019841 retinol binding(GO:0019841)
0.0 5.3 GO:0005096 GTPase activator activity(GO:0005096)
1.0 5.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 4.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 4.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 3.9 GO:0070064 proline-rich region binding(GO:0070064)
0.1 3.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 2.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.7 2.0 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.5 2.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 2.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.0 GO:0045296 cadherin binding(GO:0045296)
0.0 2.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.3 1.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.7 GO:0035497 cAMP response element binding(GO:0035497)
0.3 1.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.1 1.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 1.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)