Motif ID: Rad21_Smc3

Z-value: 0.749

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rad21mm10_v2_chr15_-_51991679_51991760-0.184.0e-01Click!
Smc3mm10_v2_chr19_+_53600377_53600435-0.019.5e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_110168204 2.205 ENSMUST00000003754.6
 Calb2
calbindin 2
chr2_-_117342709 1.730 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr2_+_157914618 1.619 ENSMUST00000109523.1
 Vstm2l
V-set and transmembrane domain containing 2-like
chr5_+_147957310 1.482 ENSMUST00000085558.4
ENSMUST00000129092.1
 Mtus2

microtubule associated tumor suppressor candidate 2

chr18_-_34007206 1.447 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chr17_+_34135182 1.406 ENSMUST00000042121.9
 H2-DMa
histocompatibility 2, class II, locus DMa
chr8_+_119446719 1.333 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr9_-_42944479 1.280 ENSMUST00000114865.1
 Grik4
glutamate receptor, ionotropic, kainate 4
chr18_+_74442500 1.247 ENSMUST00000074157.6
 Myo5b
myosin VB
chr19_-_12501996 1.219 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr18_+_74442551 1.192 ENSMUST00000121875.1
 Myo5b
myosin VB
chr7_+_35119285 1.168 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr2_-_32353283 1.148 ENSMUST00000091089.5
ENSMUST00000113350.1
 Dnm1

dynamin 1

chr18_-_61911783 1.114 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr7_+_16310412 1.083 ENSMUST00000136781.1
 Bbc3
BCL2 binding component 3
chr2_-_32353247 1.083 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr7_-_19698206 1.040 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr19_-_45816007 1.039 ENSMUST00000079431.3
ENSMUST00000026247.6
ENSMUST00000162528.2
 Kcnip2


Kv channel-interacting protein 2


chr8_+_87472805 1.035 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr11_-_59964936 0.995 ENSMUST00000062405.7
 Rasd1
RAS, dexamethasone-induced 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.4 GO:0032439 endosome localization(GO:0032439)
0.3 2.3 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.6 1.9 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.5 1.9 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 1.7 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of interferon-gamma secretion(GO:1902715) positive regulation of thymocyte aggregation(GO:2000400)
0.5 1.4 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.2 1.3 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.4 1.2 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.3 1.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.2 1.0 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.0 GO:0043206 extracellular fibril organization(GO:0043206)
0.1 1.0 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 1.0 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 1.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 1.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 0.9 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.2 0.9 GO:0019236 response to pheromone(GO:0019236)
0.3 0.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.8 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.6 GO:0045179 apical cortex(GO:0045179)
0.1 2.2 GO:0005921 gap junction(GO:0005921)
0.6 1.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 1.9 GO:0043196 varicosity(GO:0043196)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 1.4 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 1.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 1.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 0.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.6 GO:0043218 compact myelin(GO:0043218)
0.0 0.6 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.5 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 2.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.6 1.9 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 1.9 GO:0051117 ATPase binding(GO:0051117)
0.1 1.5 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.4 GO:0023026 MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026)
0.1 1.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.4 1.2 GO:0004454 ketohexokinase activity(GO:0004454)
0.1 1.2 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.2 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.0 GO:0030332 cyclin binding(GO:0030332)
0.2 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 0.6 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.6 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573)
0.0 0.6 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)