Motif ID: Rara

Z-value: 0.729


Transcription factors associated with Rara:

Gene SymbolEntrez IDGene Name
Rara ENSMUSG00000037992.10 Rara

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raramm10_v2_chr11_+_98960412_989604850.781.1e-05Click!


Activity profile for motif Rara.

activity profile for motif Rara


Sorted Z-values histogram for motif Rara

Sorted Z-values for motif Rara



Network of associatons between targets according to the STRING database.



First level regulatory network of Rara

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_94875600 5.865 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr11_+_98960412 4.854 ENSMUST00000107473.2
 Rara
retinoic acid receptor, alpha
chr2_+_169633517 3.256 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr4_-_141599835 2.974 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr1_-_175692624 2.567 ENSMUST00000027809.7
 Opn3
opsin 3
chr17_+_34593388 2.236 ENSMUST00000174532.1
 Pbx2
pre B cell leukemia homeobox 2
chr3_-_54915867 2.074 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr7_-_17056669 1.588 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr6_+_91157373 1.530 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr4_+_150853919 1.068 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr4_+_32238713 1.005 ENSMUST00000108180.2
 Bach2
BTB and CNC homology 2
chr2_-_5012716 1.003 ENSMUST00000027980.7
 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr2_+_5845243 0.964 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr4_+_32238950 0.963 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr14_+_58070547 0.959 ENSMUST00000165526.1
 Fgf9
fibroblast growth factor 9
chrX_+_106187100 0.898 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr10_+_4611971 0.819 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr12_-_108893197 0.811 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr11_+_94629741 0.801 ENSMUST00000021239.6
 Lrrc59
leucine rich repeat containing 59
chr10_-_89257790 0.653 ENSMUST00000045601.7
 Ano4
anoctamin 4
chr6_+_30723541 0.637 ENSMUST00000115127.1
 Mest
mesoderm specific transcript
chr8_-_94876269 0.601 ENSMUST00000046461.7
 Dok4
docking protein 4
chrX_+_74254782 0.582 ENSMUST00000119197.1
ENSMUST00000088313.4
 Emd

emerin

chr2_+_5845017 0.543 ENSMUST00000026927.3
ENSMUST00000179748.1
 Nudt5

nudix (nucleoside diphosphate linked moiety X)-type motif 5

chr14_+_20674311 0.527 ENSMUST00000048657.8
 Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr14_-_16575456 0.516 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr14_-_74947865 0.502 ENSMUST00000088970.5
 Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr10_+_21993890 0.498 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr8_+_106150359 0.489 ENSMUST00000034377.6
 Pla2g15
phospholipase A2, group XV
chr6_+_18848571 0.448 ENSMUST00000056398.8
 Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr12_+_87026564 0.419 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr2_+_26319741 0.418 ENSMUST00000066889.6
 Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr17_-_56133817 0.395 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr4_+_41348996 0.387 ENSMUST00000072866.5
ENSMUST00000108060.3
 Ubap1

ubiquitin-associated protein 1

chr5_+_135806859 0.385 ENSMUST00000126232.1
 Srrm3
serine/arginine repetitive matrix 3
chr2_-_5845164 0.368 ENSMUST00000043864.3
 Cdc123
cell division cycle 123
chr17_-_32388885 0.366 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr7_-_141429433 0.347 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chrX_+_74254736 0.322 ENSMUST00000096424.4
 Emd
emerin
chr3_+_152210458 0.314 ENSMUST00000166984.1
ENSMUST00000106121.1
 Fubp1

far upstream element (FUSE) binding protein 1

chr7_-_141429351 0.305 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr4_-_152318458 0.269 ENSMUST00000170820.1
ENSMUST00000076183.5
 Rnf207

ring finger protein 207

chr3_+_89229046 0.245 ENSMUST00000041142.3
 Muc1
mucin 1, transmembrane
chr11_+_4986824 0.225 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr11_-_5915124 0.218 ENSMUST00000109823.2
ENSMUST00000109822.1
 Gck

glucokinase

chr11_-_50953745 0.214 ENSMUST00000162420.1
ENSMUST00000051159.2
 Prop1

paired like homeodomain factor 1

chrX_-_75874536 0.205 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr7_+_45873127 0.179 ENSMUST00000107718.1
 Kdelr1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr7_+_45872772 0.178 ENSMUST00000002855.5
ENSMUST00000107719.1
 Kdelr1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr5_+_53590215 0.158 ENSMUST00000037618.6
 Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr13_+_49421229 0.141 ENSMUST00000021817.8
 Ippk
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr6_-_39810881 0.117 ENSMUST00000114797.1
ENSMUST00000031978.8
 Mrps33

mitochondrial ribosomal protein S33

chr2_-_34754364 0.112 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
 Gapvd1


GTPase activating protein and VPS9 domains 1


chr3_+_79884576 0.110 ENSMUST00000145992.1
 Fam198b
family with sequence similarity 198, member B
chrX_-_59567348 0.096 ENSMUST00000124402.1
 Fgf13
fibroblast growth factor 13
chr8_+_69659263 0.071 ENSMUST00000169125.1
 Zfp964
zinc finger protein 964
chr5_+_53267103 0.064 ENSMUST00000121042.1
 Smim20
small integral membrane protein 20
chr19_-_7241216 0.060 ENSMUST00000025675.9
 Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr7_+_120635176 0.057 ENSMUST00000033176.5
 Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr4_-_128609981 0.051 ENSMUST00000141040.1
ENSMUST00000147876.1
ENSMUST00000097877.2
 Zscan20


zinc finger and SCAN domains 20


chr12_-_54862783 0.032 ENSMUST00000078124.7
 Cfl2
cofilin 2, muscle
chr5_-_105239533 0.023 ENSMUST00000065588.6
 Gbp10
guanylate-binding protein 10
chr11_+_3488275 0.021 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr2_+_131262469 0.016 ENSMUST00000150843.1
 Pank2
pantothenate kinase 2
chr4_+_141444654 0.014 ENSMUST00000006377.6
 Zbtb17
zinc finger and BTB domain containing 17
chr9_-_43105718 0.008 ENSMUST00000165665.1
 Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr11_-_97700327 0.001 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.9 2.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.4 6.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.4 1.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.3 0.8 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 0.7 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.2 0.7 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.2 3.0 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 0.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 0.4 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.1 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 1.5 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.1 0.2 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 1.1 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214)
0.1 2.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.3 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.1 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.9 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.4 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 1.0 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.5 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.6 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.9 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.3 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.2 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 0.9 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.9 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.6 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0009881 photoreceptor activity(GO:0009881)
0.5 4.9 GO:0001972 retinoic acid binding(GO:0001972)
0.3 0.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.3 0.8 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 2.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 0.9 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 1.5 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.2 3.0 GO:0031005 filamin binding(GO:0031005)
0.1 1.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 1.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.6 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)