Motif ID: Rela_Rel_Nfkb1

Z-value: 1.452

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relamm10_v2_chr19_+_5637475_5637486-0.565.4e-03Click!
Nfkb1mm10_v2_chr3_-_135608221_1356082900.048.6e-01Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_165234689 11.277 ENSMUST00000065438.6
 Cdh22
cadherin 22
chr1_+_74791516 9.660 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr6_+_4755327 5.173 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr7_-_103843154 4.800 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr8_-_61902669 3.768 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr6_+_48841633 3.355 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr6_+_48841476 3.355 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_8948608 3.313 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr19_-_58454580 3.004 ENSMUST00000129100.1
ENSMUST00000123957.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr19_-_58455161 2.991 ENSMUST00000135730.1
ENSMUST00000152507.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr17_-_23745829 2.987 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chr12_+_109747903 2.933 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr4_+_13743424 2.842 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_64532790 2.819 ENSMUST00000049932.5
ENSMUST00000087366.4
ENSMUST00000171164.1
 Creb1


cAMP responsive element binding protein 1


chr14_-_30607808 2.751 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr19_-_58454435 2.732 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr18_+_4994600 2.706 ENSMUST00000140448.1
 Svil
supervillin
chr2_-_26294550 2.653 ENSMUST00000057224.3
 4932418E24Rik
RIKEN cDNA 4932418E24 gene
chr6_+_34354119 2.535 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr2_-_37422869 2.486 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 11.9 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.9 11.2 GO:0048733 sebaceous gland development(GO:0048733)
0.6 10.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 6.7 GO:0008063 Toll signaling pathway(GO:0008063)
1.0 4.8 GO:0015671 oxygen transport(GO:0015671)
0.8 3.9 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.2 3.9 GO:0003334 keratinocyte development(GO:0003334)
0.1 3.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.3 3.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.0 3.0 GO:0016115 terpenoid catabolic process(GO:0016115)
0.1 3.0 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.9 2.8 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.2 2.5 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 2.4 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.6 2.3 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 2.3 GO:0007286 spermatid development(GO:0007286)
0.5 2.2 GO:0042414 epinephrine metabolic process(GO:0042414)
0.4 2.2 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.1 2.2 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.2 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 GO:0031225 anchored component of membrane(GO:0031225)
0.4 6.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.6 4.8 GO:0005833 hemoglobin complex(GO:0005833)
0.0 4.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 4.6 GO:0043034 costamere(GO:0043034)
0.0 3.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 3.4 GO:0002102 podosome(GO:0002102)
0.0 2.6 GO:0000922 spindle pole(GO:0000922)
0.2 2.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 2.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 2.2 GO:0098536 deuterosome(GO:0098536)
0.1 1.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 1.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.7 GO:0030496 midbody(GO:0030496)
0.3 1.6 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 1.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 1.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.5 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.3 GO:0005109 frizzled binding(GO:0005109)
0.0 9.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 7.2 GO:0005178 integrin binding(GO:0005178)
0.6 6.7 GO:0031996 thioesterase binding(GO:0031996)
0.0 5.5 GO:0051015 actin filament binding(GO:0051015)
1.2 4.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.0 3.9 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.4 3.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 2.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.8 GO:0003729 mRNA binding(GO:0003729)
0.4 2.5 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.3 2.3 GO:0043495 protein anchor(GO:0043495)
0.3 2.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 2.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.7 2.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 2.0 GO:0005272 sodium channel activity(GO:0005272)
0.5 1.9 GO:1990254 keratin filament binding(GO:1990254)
0.0 1.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)