Motif ID: Rest

Z-value: 1.951


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77265454_772655490.424.7e-02Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_42255704 11.631 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr16_-_23890805 10.925 ENSMUST00000004480.3
 Sst
somatostatin
chr6_-_121473630 10.001 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr5_-_121009510 9.512 ENSMUST00000079204.5
 Rph3a
rabphilin 3A
chr2_-_28916412 9.015 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chr6_+_8948608 7.258 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr12_-_112511136 6.364 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr4_-_153482768 6.259 ENSMUST00000105646.2
 Ajap1
adherens junction associated protein 1
chr1_-_84696182 5.873 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr2_-_28916668 4.869 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr15_-_76521902 4.219 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr13_-_23991158 3.928 ENSMUST00000021770.7
 Scgn
secretagogin, EF-hand calcium binding protein
chr4_+_15881255 3.732 ENSMUST00000029876.1
 Calb1
calbindin 1
chr7_+_122671401 3.567 ENSMUST00000182095.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr1_+_34579693 3.458 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr13_-_54749849 3.418 ENSMUST00000135343.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr7_+_122671378 3.223 ENSMUST00000182563.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr13_-_54749627 3.186 ENSMUST00000099506.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr11_-_35798884 3.113 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr19_+_22139028 3.091 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
 Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr9_+_104569754 3.011 ENSMUST00000077190.6
 Cpne4
copine IV
chr2_-_27142429 2.954 ENSMUST00000151224.2
 Fam163b
family with sequence similarity 163, member B
chr9_+_104569671 2.870 ENSMUST00000057742.8
 Cpne4
copine IV
chr17_+_28575718 2.824 ENSMUST00000080780.6
 Lhfpl5
lipoma HMGIC fusion partner-like 5
chr9_-_63146980 2.768 ENSMUST00000055281.7
ENSMUST00000119146.1
 Skor1

SKI family transcriptional corepressor 1

chr17_-_91092715 2.307 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr8_+_84946987 2.184 ENSMUST00000067472.7
ENSMUST00000109740.2
 Rtbdn

retbindin

chr9_+_59578192 2.158 ENSMUST00000118549.1
ENSMUST00000034840.3
 Celf6

CUGBP, Elav-like family member 6

chr2_-_25319095 2.119 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr7_+_63444741 2.060 ENSMUST00000058476.7
 Otud7a
OTU domain containing 7A
chr7_-_79594924 2.008 ENSMUST00000172788.1
 Rhcg
Rhesus blood group-associated C glycoprotein
chr2_-_181314500 1.996 ENSMUST00000103045.3
 Stmn3
stathmin-like 3
chr12_-_84698769 1.890 ENSMUST00000095550.2
 Syndig1l
synapse differentiation inducing 1 like
chr7_-_27396542 1.854 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr17_-_23740301 1.710 ENSMUST00000024702.3
 Paqr4
progestin and adipoQ receptor family member IV
chr4_+_101550411 1.601 ENSMUST00000094953.4
ENSMUST00000106933.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr9_+_40269273 1.591 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr2_-_25319187 1.590 ENSMUST00000114312.1
 Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr2_-_180889660 1.585 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr13_-_99900645 1.584 ENSMUST00000022150.6
 Cartpt
CART prepropeptide
chr9_+_40269430 1.551 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 1.504 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr15_-_75747922 1.483 ENSMUST00000062002.4
 Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr13_-_56895737 1.291 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr1_-_34579613 1.282 ENSMUST00000062557.3
 1700101I19Rik
RIKEN cDNA 1700101I19 gene
chrX_-_20920911 1.187 ENSMUST00000081893.6
ENSMUST00000115345.1
 Syn1

synapsin I

chr9_+_40873981 1.081 ENSMUST00000067375.3
 Bsx
brain specific homeobox
chr11_-_3774706 1.025 ENSMUST00000155197.1
 Osbp2
oxysterol binding protein 2
chr5_+_137030275 1.020 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chrX_+_7638674 0.986 ENSMUST00000128890.1
 Syp
synaptophysin
chr11_+_76202007 0.916 ENSMUST00000094014.3
 Fam57a
family with sequence similarity 57, member A
chr12_+_113140198 0.867 ENSMUST00000084882.4
 Crip2
cysteine rich protein 2
chr18_-_31447383 0.856 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr15_-_76722161 0.854 ENSMUST00000049956.4
 Lrrc24
leucine rich repeat containing 24
chr11_+_76202084 0.824 ENSMUST00000169560.1
 Fam57a
family with sequence similarity 57, member A
chr7_-_81493883 0.787 ENSMUST00000082090.7
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr10_+_90829538 0.757 ENSMUST00000179694.2
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr16_+_30065333 0.730 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr7_+_27653906 0.718 ENSMUST00000008088.7
 Ttc9b
tetratricopeptide repeat domain 9B
chr5_+_104046869 0.593 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr10_+_90829409 0.538 ENSMUST00000182202.1
ENSMUST00000182966.1
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr8_+_18846251 0.508 ENSMUST00000149565.1
ENSMUST00000033847.4
 Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr19_-_45046614 0.490 ENSMUST00000145391.1
 Pdzd7
PDZ domain containing 7
chr8_+_69088646 0.481 ENSMUST00000006435.7
 Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr2_+_157456917 0.360 ENSMUST00000109529.1
 Src
Rous sarcoma oncogene
chr5_+_104046526 0.328 ENSMUST00000150226.1
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr14_+_32321987 0.314 ENSMUST00000022480.7
 Ogdhl
oxoglutarate dehydrogenase-like
chr11_+_80477015 0.235 ENSMUST00000053413.10
ENSMUST00000147694.1
 Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr3_-_109027600 0.203 ENSMUST00000171143.1
 Fam102b
family with sequence similarity 102, member B
chr9_+_40801235 0.141 ENSMUST00000117870.1
ENSMUST00000117557.1
 Hspa8

heat shock protein 8

chr4_+_129136948 0.060 ENSMUST00000102600.3
 Fndc5
fibronectin type III domain containing 5
chr4_+_130055010 0.040 ENSMUST00000123617.1
 Col16a1
collagen, type XVI, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:1900673 olefin metabolic process(GO:1900673)
0.7 2.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.7 2.0 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.6 3.1 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.5 5.9 GO:0007220 Notch receptor processing(GO:0007220)
0.5 1.6 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.5 4.6 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.5 2.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.4 2.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.4 10.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 1.0 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.3 10.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 1.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 0.9 GO:0046032 ADP catabolic process(GO:0046032)
0.3 1.7 GO:0072318 clathrin coat disassembly(GO:0072318)
0.3 6.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 14.6 GO:0030901 midbrain development(GO:0030901)
0.2 3.3 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.2 3.7 GO:0007614 short-term memory(GO:0007614)
0.1 0.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.2 GO:0021586 pons maturation(GO:0021586)
0.1 2.2 GO:0071625 vocalization behavior(GO:0071625)
0.1 1.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.0 GO:0043084 penile erection(GO:0043084)
0.1 4.2 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 1.1 GO:0060056 mammary gland involution(GO:0060056)
0.1 1.5 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.1 2.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 1.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.7 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.5 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 2.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 0.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.7 GO:0061077 chaperone-mediated protein folding(GO:0061077)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0044307 dendritic branch(GO:0044307)
0.6 2.8 GO:0032426 stereocilium tip(GO:0032426)
0.4 3.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 1.9 GO:0008091 spectrin(GO:0008091)
0.3 4.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.3 7.9 GO:0060077 inhibitory synapse(GO:0060077)
0.2 0.5 GO:0002141 stereocilia ankle link(GO:0002141)
0.2 6.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 4.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.0 GO:0097440 apical dendrite(GO:0097440)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.1 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.5 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 2.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.0 GO:0030667 secretory granule membrane(GO:0030667)
0.0 5.9 GO:0005769 early endosome(GO:0005769)
0.0 7.9 GO:0043025 neuronal cell body(GO:0043025)
0.0 2.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 9.5 GO:0042301 phosphate ion binding(GO:0042301)
0.7 4.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 3.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.3 10.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 13.6 GO:0005179 hormone activity(GO:0005179)
0.2 5.9 GO:0005112 Notch binding(GO:0005112)
0.2 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 3.9 GO:0030506 ankyrin binding(GO:0030506)
0.2 6.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.9 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.1 1.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 5.7 GO:0043178 alcohol binding(GO:0043178)
0.1 7.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 3.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 16.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.1 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.8 GO:0046332 SMAD binding(GO:0046332)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)