Motif ID: Rfx3_Rfx1_Rfx4

Z-value: 3.675

Transcription factors associated with Rfx3_Rfx1_Rfx4:

Gene SymbolEntrez IDGene Name
Rfx1 ENSMUSG00000031706.6 Rfx1
Rfx3 ENSMUSG00000040929.10 Rfx3
Rfx4 ENSMUSG00000020037.9 Rfx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx1mm10_v2_chr8_+_84066824_84066882-0.405.7e-02Click!
Rfx4mm10_v2_chr10_+_84838143_848381530.321.3e-01Click!
Rfx3mm10_v2_chr19_-_28010995_28011054-0.048.5e-01Click!


Activity profile for motif Rfx3_Rfx1_Rfx4.

activity profile for motif Rfx3_Rfx1_Rfx4


Sorted Z-values histogram for motif Rfx3_Rfx1_Rfx4

Sorted Z-values for motif Rfx3_Rfx1_Rfx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_60925612 61.639 ENSMUST00000102888.3
ENSMUST00000025519.4
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr18_+_60925644 28.070 ENSMUST00000115297.1
 Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr7_-_31051431 20.985 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr15_+_98167806 20.176 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr2_+_121289589 16.854 ENSMUST00000094639.3
 Map1a
microtubule-associated protein 1 A
chr5_+_120431770 14.392 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5
chr16_+_14906622 12.672 ENSMUST00000090277.1
 Efcab1
EF hand calcium binding domain 1
chr11_-_105944412 12.605 ENSMUST00000019734.4
ENSMUST00000184269.1
ENSMUST00000150563.1
 Cyb561


cytochrome b-561


chr17_-_31277327 12.117 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr5_+_24985840 11.973 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr11_-_116335384 11.257 ENSMUST00000036215.7
 Foxj1
forkhead box J1
chr4_-_119415494 10.921 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30
chr14_-_8309770 9.971 ENSMUST00000121887.1
ENSMUST00000036070.8
ENSMUST00000137133.1
 Fam107a


family with sequence similarity 107, member A


chr11_-_105944128 9.932 ENSMUST00000184086.1
 Cyb561
cytochrome b-561
chr7_-_140082246 9.787 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr7_-_140082489 9.310 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr2_-_118256929 9.237 ENSMUST00000028820.6
ENSMUST00000028821.3
 Fsip1

fibrous sheath-interacting protein 1

chr6_+_56017489 9.119 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr3_+_67374091 8.189 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr4_-_153482768 7.958 ENSMUST00000105646.2
 Ajap1
adherens junction associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 89.7 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.3 22.4 GO:0022900 electron transport chain(GO:0022900)
1.0 21.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.5 17.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
3.2 16.0 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.8 14.4 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 13.4 GO:0007286 spermatid development(GO:0007286)
0.6 13.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
1.4 12.8 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
1.6 12.5 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
2.9 11.7 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
2.8 11.3 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.2 9.2 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
3.0 8.9 GO:0097402 neuroblast migration(GO:0097402)
0.3 8.2 GO:0071625 vocalization behavior(GO:0071625)
0.2 8.2 GO:0032418 lysosome localization(GO:0032418)
0.3 8.1 GO:0007340 acrosome reaction(GO:0007340)
2.0 7.9 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.7 7.5 GO:0044458 motile cilium assembly(GO:0044458)
0.2 6.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 91.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 33.4 GO:0005874 microtubule(GO:0005874)
0.3 32.0 GO:0031514 motile cilium(GO:0031514)
0.0 18.4 GO:0097708 intracellular vesicle(GO:0097708)
0.1 16.5 GO:0016607 nuclear speck(GO:0016607)
0.1 15.4 GO:0000776 kinetochore(GO:0000776)
0.2 12.3 GO:0001750 photoreceptor outer segment(GO:0001750)
1.5 11.9 GO:0001520 outer dense fiber(GO:0001520)
0.0 10.5 GO:0030054 cell junction(GO:0030054)
0.3 8.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 8.3 GO:0030141 secretory granule(GO:0030141)
0.0 7.5 GO:0009986 cell surface(GO:0009986)
0.3 7.2 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 7.0 GO:0005769 early endosome(GO:0005769)
0.2 6.8 GO:0097440 apical dendrite(GO:0097440)
0.2 6.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 6.3 GO:0031201 SNARE complex(GO:0031201)
0.8 6.2 GO:0098536 deuterosome(GO:0098536)
0.7 6.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 5.7 GO:0060170 ciliary membrane(GO:0060170)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 90.5 GO:0032794 GTPase activating protein binding(GO:0032794)
7.5 22.5 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
3.2 19.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 17.9 GO:0051117 ATPase binding(GO:0051117)
0.7 16.0 GO:0032183 SUMO binding(GO:0032183)
0.2 14.9 GO:0005518 collagen binding(GO:0005518)
0.2 13.2 GO:0035064 methylated histone binding(GO:0035064)
2.6 12.9 GO:0032027 myosin light chain binding(GO:0032027)
0.0 10.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.1 10.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 9.6 GO:0003777 microtubule motor activity(GO:0003777)
0.3 9.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 8.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 7.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 7.5 GO:0005112 Notch binding(GO:0005112)
1.0 7.2 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
2.3 6.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
1.1 6.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 6.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 6.3 GO:0005484 SNAP receptor activity(GO:0005484)