Motif ID: Rhox4e_Rhox6_Vax2

Z-value: 1.497

Transcription factors associated with Rhox4e_Rhox6_Vax2:

Gene SymbolEntrez IDGene Name
Rhox4e ENSMUSG00000071770.4 Rhox4e
Rhox6 ENSMUSG00000006200.3 Rhox6
Vax2 ENSMUSG00000034777.1 Vax2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vax2mm10_v2_chr6_+_83711232_83711288-0.174.4e-01Click!


Activity profile for motif Rhox4e_Rhox6_Vax2.

activity profile for motif Rhox4e_Rhox6_Vax2


Sorted Z-values histogram for motif Rhox4e_Rhox6_Vax2

Sorted Z-values for motif Rhox4e_Rhox6_Vax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 26.851 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_60893430 10.626 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr8_+_45658666 6.575 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 6.394 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr15_-_67113909 5.534 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_89933290 5.532 ENSMUST00000036954.7
 Gbx2
gastrulation brain homeobox 2
chr13_-_102906046 5.065 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_55782500 4.999 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr4_+_15881255 4.987 ENSMUST00000029876.1
 Calb1
calbindin 1
chr13_-_102905740 4.391 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_25005895 4.321 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr9_+_53771499 4.126 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr9_+_102720287 3.742 ENSMUST00000130602.1
 Amotl2
angiomotin-like 2
chr12_-_112511136 3.682 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr3_-_86548268 3.599 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr14_+_5517172 3.333 ENSMUST00000178220.1
 Gm3488
predicted gene, 3488
chr14_+_5164535 3.333 ENSMUST00000179659.1
 Gm3317
predicted gene 3317
chr12_+_109545390 3.101 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr12_-_40037387 3.077 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr16_-_42340595 3.076 ENSMUST00000102817.4
 Gap43
growth associated protein 43

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 26.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 16.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 10.6 GO:0007530 sex determination(GO:0007530)
0.0 10.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.8 5.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.3 5.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 5.0 GO:0007614 short-term memory(GO:0007614)
0.4 4.3 GO:0030007 cellular potassium ion homeostasis(GO:0030007)
0.2 4.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 3.7 GO:0035329 hippo signaling(GO:0035329)
0.0 3.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 3.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.3 3.1 GO:0016198 axon choice point recognition(GO:0016198)
0.1 3.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 3.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 2.9 GO:0000910 cytokinesis(GO:0000910)
0.9 2.8 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 2.6 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.2 2.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 5.0 GO:0043195 terminal bouton(GO:0043195)
0.1 4.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.6 4.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) dendritic spine neck(GO:0044326)
0.0 4.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 4.1 GO:0000792 heterochromatin(GO:0000792)
0.1 3.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.8 GO:0043034 costamere(GO:0043034)
0.3 2.6 GO:0098536 deuterosome(GO:0098536)
0.2 2.4 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.3 GO:0002102 podosome(GO:0002102)
0.0 2.2 GO:0070382 exocytic vesicle(GO:0070382)
0.2 2.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 1.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 1.3 GO:0097413 Lewy body(GO:0097413)
0.4 1.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 11.6 GO:0019904 protein domain specific binding(GO:0019904)
0.3 10.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 9.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 7.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.7 5.5 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 5.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 4.8 GO:0019842 vitamin binding(GO:0019842)
0.5 4.3 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 4.1 GO:0003779 actin binding(GO:0003779)
0.0 3.5 GO:0003924 GTPase activity(GO:0003924)
0.5 3.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 2.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 2.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 1.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 1.3 GO:0031491 nucleosome binding(GO:0031491)