Motif ID: Rreb1

Z-value: 0.823


Transcription factors associated with Rreb1:

Gene SymbolEntrez IDGene Name
Rreb1 ENSMUSG00000039087.10 Rreb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1mm10_v2_chr13_+_37826225_378263150.301.6e-01Click!


Activity profile for motif Rreb1.

activity profile for motif Rreb1


Sorted Z-values histogram for motif Rreb1

Sorted Z-values for motif Rreb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rreb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_35076902 3.296 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr11_-_69369377 3.067 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr15_+_83791939 2.763 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr17_+_35077080 2.179 ENSMUST00000172959.1
 Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr11_+_67586675 1.704 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr13_+_43615710 1.528 ENSMUST00000059986.2
 Rnf182
ring finger protein 182
chr5_-_89883321 1.522 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr11_+_67586520 1.464 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr12_+_81026800 1.447 ENSMUST00000110347.2
ENSMUST00000021564.4
ENSMUST00000129362.1
 Smoc1


SPARC related modular calcium binding 1


chr5_+_37047464 1.392 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr4_+_101419696 1.348 ENSMUST00000131397.1
ENSMUST00000133055.1
 Ak4

adenylate kinase 4

chr12_+_81859964 1.268 ENSMUST00000021567.5
 Pcnx
pecanex homolog (Drosophila)
chr2_+_92599671 1.252 ENSMUST00000065797.6
 Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr18_-_74961252 1.146 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr7_+_5056706 1.101 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106
chr5_-_122002340 1.074 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr4_+_101419277 1.073 ENSMUST00000102780.1
ENSMUST00000106946.1
ENSMUST00000106945.1
 Ak4


adenylate kinase 4


chr19_+_8664005 1.054 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr13_+_109632760 1.039 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr7_+_100495987 1.013 ENSMUST00000133044.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 4.1 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 3.2 GO:0051297 centrosome organization(GO:0051297)
0.1 2.2 GO:0046033 AMP metabolic process(GO:0046033)
0.1 2.0 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.3 1.8 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 1.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 1.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.3 1.5 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.0 1.5 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 1.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 1.3 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 1.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 1.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 1.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.2 1.2 GO:0034436 glycoprotein transport(GO:0034436)
0.1 1.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.4 1.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.0 1.1 GO:2000463 positive regulation of dendritic spine morphogenesis(GO:0061003) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.3 1.0 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.8 GO:0005884 actin filament(GO:0005884)
0.1 1.5 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 1.1 GO:0016342 catenin complex(GO:0016342)
0.1 1.1 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 1.1 GO:0005604 basement membrane(GO:0005604) extracellular matrix component(GO:0044420)
0.0 1.0 GO:0009986 cell surface(GO:0009986)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.9 GO:0044297 cell body(GO:0044297)
0.1 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.2 0.6 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 5.5 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 3.0 GO:0051015 actin filament binding(GO:0051015)
0.0 2.8 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.8 2.4 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.3 1.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 1.5 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 1.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 1.3 GO:1990188 euchromatin binding(GO:1990188)
0.0 1.3 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 1.3 GO:0000049 tRNA binding(GO:0000049)
0.4 1.2 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.2 1.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 1.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 1.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)