Motif ID: Runx1

Z-value: 0.894


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_42907563 7.124 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr3_-_107760221 5.041 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr17_+_3397189 3.967 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr8_-_11008458 3.693 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr15_-_66801577 3.570 ENSMUST00000168589.1
 Sla
src-like adaptor
chr17_+_75178797 3.065 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr1_-_14310198 2.970 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr16_+_43510267 2.877 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr12_-_34528844 2.730 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr17_+_75178911 2.611 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr13_+_76579670 2.564 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr13_+_49608030 2.302 ENSMUST00000021822.5
 Ogn
osteoglycin
chr12_-_25096080 2.134 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chrX_+_151344171 2.098 ENSMUST00000073364.5
 Fam120c
family with sequence similarity 120, member C
chr5_+_104435112 2.042 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr2_-_116065798 1.786 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2

chr15_-_102722120 1.737 ENSMUST00000171838.1
 Calcoco1
calcium binding and coiled coil domain 1
chr15_-_76090013 1.710 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chr15_-_102722150 1.646 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1
chr14_+_31641051 1.556 ENSMUST00000090147.6
 Btd
biotinidase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 5.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
1.7 5.0 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 3.7 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 3.6 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 3.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 3.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.5 3.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.4 2.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.3 2.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 2.0 GO:0033280 response to vitamin D(GO:0033280)
0.0 1.8 GO:0008542 visual learning(GO:0008542)
0.0 1.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 1.6 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.2 1.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.2 1.4 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 1.2 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 1.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 1.1 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1 1.1 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 5.5 GO:0000785 chromatin(GO:0000785)
1.7 5.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.0 1.5 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 1.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.1 0.9 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.9 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 0.6 GO:1990037 Lewy body core(GO:1990037)
0.1 0.6 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.5 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 7.4 GO:0005125 cytokine activity(GO:0005125)
1.4 5.7 GO:0050436 microfibril binding(GO:0050436)
0.0 4.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 3.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 3.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 2.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.3 GO:0008201 heparin binding(GO:0008201)
0.0 2.3 GO:0044325 ion channel binding(GO:0044325)
0.7 2.1 GO:0001851 complement component C3b binding(GO:0001851)
0.0 1.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.4 1.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 1.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 1.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)