Motif ID: Runx2_Bcl11a

Z-value: 1.457

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24078173_24078219-0.405.6e-02Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 11.140 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr8_-_11008458 7.973 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr4_+_144892813 7.251 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_+_58210397 5.757 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chrX_+_159697308 4.650 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr4_+_144893127 4.496 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr15_-_66801577 4.419 ENSMUST00000168589.1
 Sla
src-like adaptor
chr1_-_172297989 4.374 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr11_+_3330781 4.262 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr5_-_77408034 4.231 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chr16_+_42907563 4.069 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr9_-_103219823 3.752 ENSMUST00000168142.1
 Trf
transferrin
chr11_+_101246960 3.740 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr11_-_106388066 3.615 ENSMUST00000106813.2
ENSMUST00000141146.1
 Icam2

intercellular adhesion molecule 2

chr4_+_48049080 3.525 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr11_+_78322965 3.510 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr11_+_80183851 3.377 ENSMUST00000017839.2
 Rnf135
ring finger protein 135
chr1_+_169655493 3.289 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr17_+_88626549 3.262 ENSMUST00000163588.1
ENSMUST00000064035.6
 Ston1

stonin 1

chr17_+_75178797 3.254 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 274 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 14.4 GO:0042572 retinol metabolic process(GO:0042572)
0.8 7.5 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.2 7.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.0 6.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.9 5.8 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 5.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.7 4.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.5 4.4 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 4.3 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.5 3.8 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.4 3.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.2 3.5 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.6 3.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.5 3.2 GO:0015862 uridine transport(GO:0015862)
0.3 3.2 GO:0051923 sulfation(GO:0051923)
0.0 3.1 GO:0008360 regulation of cell shape(GO:0008360)
1.0 3.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.4 2.9 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 2.8 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2.8 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 9.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 7.1 GO:0043235 receptor complex(GO:0043235)
2.0 5.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 5.9 GO:0072562 blood microparticle(GO:0072562)
0.0 5.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 3.8 GO:0097433 dense body(GO:0097433)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.4 3.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 3.5 GO:0030139 endocytic vesicle(GO:0030139)
0.0 3.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 3.1 GO:0043204 perikaryon(GO:0043204)
0.4 3.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 2.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 2.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.3 GO:0009925 basal plasma membrane(GO:0009925)
0.2 2.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.2 GO:0031430 M band(GO:0031430)
0.1 2.1 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 14.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 12.0 GO:0005158 insulin receptor binding(GO:0005158)
2.8 11.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
2.3 6.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 6.1 GO:0005178 integrin binding(GO:0005178)
1.4 5.8 GO:0030151 molybdenum ion binding(GO:0030151)
1.4 5.6 GO:0050436 microfibril binding(GO:0050436)
0.3 5.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.2 4.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 4.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 4.5 GO:1990239 steroid hormone binding(GO:1990239)
0.1 4.3 GO:0008083 growth factor activity(GO:0008083)
0.2 4.1 GO:0050811 GABA receptor binding(GO:0050811)
0.5 3.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 3.7 GO:0015026 coreceptor activity(GO:0015026)
1.1 3.4 GO:0001851 complement component C3b binding(GO:0001851)
0.1 3.3 GO:0050840 extracellular matrix binding(GO:0050840)
1.1 3.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.8 3.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)