Motif ID: Runx3

Z-value: 0.590


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_47368446 1.175 ENSMUST00000076043.6
ENSMUST00000135790.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_+_35802593 1.089 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr13_-_22041352 0.950 ENSMUST00000102977.2
Hist1h4i
histone cluster 1, H4i
chr15_-_72546279 0.876 ENSMUST00000044624.6
Kcnk9
potassium channel, subfamily K, member 9
chr7_+_141216626 0.868 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr13_+_21735055 0.833 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr14_-_20181773 0.810 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chrX_-_73869804 0.792 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr13_-_23698454 0.762 ENSMUST00000102967.1
Hist1h4c
histone cluster 1, H4c
chrX_+_99136119 0.734 ENSMUST00000052839.6
Efnb1
ephrin B1
chr17_+_27556613 0.732 ENSMUST00000117600.1
ENSMUST00000114888.3
Hmga1

high mobility group AT-hook 1

chr17_+_27556668 0.729 ENSMUST00000117254.1
ENSMUST00000118570.1
Hmga1

high mobility group AT-hook 1

chr17_+_27556641 0.719 ENSMUST00000119486.1
ENSMUST00000118599.1
Hmga1

high mobility group AT-hook 1

chr6_-_99632376 0.610 ENSMUST00000176255.1
Gm20696
predicted gene 20696
chr11_-_89302545 0.602 ENSMUST00000061728.3
Nog
noggin
chr13_-_23551648 0.600 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr10_+_128083273 0.569 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr14_-_72709534 0.525 ENSMUST00000162478.1
Fndc3a
fibronectin type III domain containing 3A
chr13_-_21832194 0.483 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr7_-_78783026 0.476 ENSMUST00000032841.5
Mrpl46
mitochondrial ribosomal protein L46
chr3_+_95658771 0.409 ENSMUST00000178686.1
Mcl1
myeloid cell leukemia sequence 1
chr11_-_70220794 0.394 ENSMUST00000159867.1
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr7_-_16816731 0.384 ENSMUST00000061390.7
Fkrp
fukutin related protein
chr9_-_78481724 0.374 ENSMUST00000042235.8
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr17_+_30005029 0.351 ENSMUST00000057897.7
Zfand3
zinc finger, AN1-type domain 3
chr18_-_3337539 0.347 ENSMUST00000142690.1
ENSMUST00000025069.4
ENSMUST00000082141.5
ENSMUST00000165086.1
ENSMUST00000149803.1
Crem




cAMP responsive element modulator




chr11_-_70220776 0.345 ENSMUST00000141290.1
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr13_-_35906324 0.310 ENSMUST00000174230.1
ENSMUST00000171686.2
Rpp40

ribonuclease P 40 subunit

chr7_+_28808795 0.306 ENSMUST00000172529.1
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr6_-_100671126 0.303 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
Shq1


SHQ1 homolog (S. cerevisiae)


chr7_-_35802968 0.297 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr3_+_122245625 0.283 ENSMUST00000178826.1
Gclm
glutamate-cysteine ligase, modifier subunit
chr13_-_25020289 0.268 ENSMUST00000021772.2
Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr9_-_108094459 0.266 ENSMUST00000081309.7
Apeh
acylpeptide hydrolase
chr10_-_62602261 0.260 ENSMUST00000045866.7
Ddx21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr5_-_25223153 0.260 ENSMUST00000066954.1
E130116L18Rik
RIKEN cDNA E130116L18 gene
chr4_-_120570252 0.251 ENSMUST00000030381.7
Ctps
cytidine 5'-triphosphate synthase
chr7_+_78783119 0.250 ENSMUST00000032840.4
Mrps11
mitochondrial ribosomal protein S11
chr13_-_51734695 0.250 ENSMUST00000110039.1
Sema4d
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr13_+_51645232 0.244 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr9_+_106429399 0.242 ENSMUST00000150576.1
Rpl29
ribosomal protein L29
chr11_+_75679259 0.234 ENSMUST00000017920.7
ENSMUST00000108426.1
ENSMUST00000108425.1
ENSMUST00000093115.3
Crk



v-crk sarcoma virus CT10 oncogene homolog (avian)



chrX_-_98890781 0.226 ENSMUST00000113826.1
ENSMUST00000033560.2
ENSMUST00000142267.1
Ophn1


oligophrenin 1


chr18_-_77713978 0.218 ENSMUST00000074653.4
8030462N17Rik
RIKEN cDNA 8030462N17 gene
chr3_+_95658714 0.212 ENSMUST00000037947.8
Mcl1
myeloid cell leukemia sequence 1
chr9_+_106429537 0.210 ENSMUST00000059802.6
Rpl29
ribosomal protein L29
chr7_-_141437587 0.202 ENSMUST00000172654.1
ENSMUST00000106006.1
Slc25a22

solute carrier family 25 (mitochondrial carrier, glutamate), member 22

chr11_+_75532099 0.193 ENSMUST00000169547.2
Slc43a2
solute carrier family 43, member 2
chr11_-_23665862 0.187 ENSMUST00000020523.3
Pex13
peroxisomal biogenesis factor 13
chr11_-_70410010 0.176 ENSMUST00000019065.3
ENSMUST00000135148.1
Pelp1

proline, glutamic acid and leucine rich protein 1

chr3_-_154330543 0.159 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr3_+_122245557 0.156 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chr11_-_5762358 0.153 ENSMUST00000120306.1
ENSMUST00000170116.1
ENSMUST00000053427.4
ENSMUST00000118076.1
Urgcp



upregulator of cell proliferation



chr13_-_14063395 0.147 ENSMUST00000170957.1
Ggps1
geranylgeranyl diphosphate synthase 1
chr9_+_109931774 0.144 ENSMUST00000169851.2
Map4
microtubule-associated protein 4
chr8_+_4243264 0.144 ENSMUST00000110996.1
Map2k7
mitogen-activated protein kinase kinase 7
chr5_+_121397936 0.141 ENSMUST00000042163.8
Naa25
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
chr17_+_35879770 0.141 ENSMUST00000025292.8
Dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr1_-_24100306 0.139 ENSMUST00000027337.8
Fam135a
family with sequence similarity 135, member A
chr10_+_76531593 0.133 ENSMUST00000048678.6
Lss
lanosterol synthase
chr11_+_75532127 0.128 ENSMUST00000127226.1
Slc43a2
solute carrier family 43, member 2
chr15_+_8169067 0.123 ENSMUST00000110617.1
2410089E03Rik
RIKEN cDNA 2410089E03 gene
chr1_+_40465976 0.118 ENSMUST00000108044.2
ENSMUST00000087983.2
Il18r1

interleukin 18 receptor 1

chr2_+_145785980 0.110 ENSMUST00000110005.1
ENSMUST00000094480.4
Rin2

Ras and Rab interactor 2

chr8_+_27023793 0.108 ENSMUST00000033873.7
Erlin2
ER lipid raft associated 2
chr4_-_133672601 0.105 ENSMUST00000062118.4
ENSMUST00000067902.6
Pigv

phosphatidylinositol glycan anchor biosynthesis, class V

chr5_+_25222862 0.094 ENSMUST00000045737.7
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr1_+_159232299 0.090 ENSMUST00000076894.5
Rfwd2
ring finger and WD repeat domain 2
chr9_-_20898592 0.083 ENSMUST00000004206.8
Eif3g
eukaryotic translation initiation factor 3, subunit G
chr11_-_5878207 0.082 ENSMUST00000102922.3
Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr2_+_155517948 0.081 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
Acss2


acyl-CoA synthetase short-chain family member 2


chr15_-_95655960 0.073 ENSMUST00000054244.6
Dbx2
developing brain homeobox 2
chr14_-_72709986 0.073 ENSMUST00000089017.5
Fndc3a
fibronectin type III domain containing 3A
chr7_+_3617357 0.072 ENSMUST00000076657.4
ENSMUST00000108644.1
Ndufa3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3

chr11_-_70220969 0.063 ENSMUST00000060010.2
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr7_-_142095266 0.058 ENSMUST00000039926.3
Dusp8
dual specificity phosphatase 8
chr2_-_50296680 0.039 ENSMUST00000144143.1
ENSMUST00000102769.4
ENSMUST00000133768.1
Mmadhc


methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria


chr9_+_122117338 0.029 ENSMUST00000120173.1
ENSMUST00000134949.1
ENSMUST00000119215.1
Snrk


SNF related kinase


chr16_+_92301266 0.028 ENSMUST00000063641.4
ENSMUST00000118064.1
Smim11

small integral membrane protein 11

chr10_-_81001338 0.023 ENSMUST00000099462.1
ENSMUST00000118233.1
Gng7

guanine nucleotide binding protein (G protein), gamma 7

chr8_-_54724474 0.016 ENSMUST00000175915.1
Wdr17
WD repeat domain 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 1.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 0.6 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 0.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 0.6 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.3 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.3 GO:1900220 negative regulation of alkaline phosphatase activity(GO:0010693) semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 1.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.4 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 2.2 GO:0006284 base-excision repair(GO:0006284)
0.0 0.3 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 0.7 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.4 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083)
0.0 0.3 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.3 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.4 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364) negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.0 0.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.4 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.6 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 3.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 0.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.1 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.2 0.8 GO:0033691 sialic acid binding(GO:0033691)
0.2 1.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.4 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.4 GO:0043842 Kdo transferase activity(GO:0043842)
0.1 0.3 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0048045 4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.0 3.1 GO:0042393 histone binding(GO:0042393)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0031559 oxidosqualene cyclase activity(GO:0031559)