Motif ID: Six3_Six1_Six2

Z-value: 0.825

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six1mm10_v2_chr12_-_73047179_730471790.602.7e-03Click!
Six3mm10_v2_chr17_+_85613432_85613608-0.321.3e-01Click!
Six2mm10_v2_chr17_-_85688252_856882750.311.6e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_85722474 9.303 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr13_+_94083490 6.888 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr7_-_126676357 3.576 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr15_-_75894474 3.512 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_-_126676428 2.642 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr5_+_139423151 2.485 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr9_+_72958785 1.914 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr8_+_57455898 1.852 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr13_+_43785107 1.834 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr6_+_48537560 1.802 ENSMUST00000040361.5
 Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr4_-_32950813 1.513 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr3_+_94398517 1.511 ENSMUST00000050975.3
 Lingo4
leucine rich repeat and Ig domain containing 4
chr15_+_98571004 1.489 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chrX_-_142966709 1.450 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chrX_+_169685191 1.347 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr2_+_106693185 1.121 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr18_+_56432116 0.979 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr2_+_127336152 0.975 ENSMUST00000028846.6
 Dusp2
dual specificity phosphatase 2
chr17_-_56717681 0.722 ENSMUST00000164907.1
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr14_+_123659971 0.707 ENSMUST00000049681.7
 Itgbl1
integrin, beta-like 1
chr17_-_56716788 0.696 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr7_+_30231884 0.678 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr15_+_82252397 0.629 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr2_+_131491764 0.565 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
 Smox






spermine oxidase






chr9_+_65141154 0.542 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr5_-_106926245 0.505 ENSMUST00000117588.1
 Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr10_+_24595623 0.480 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr11_-_69695521 0.448 ENSMUST00000181261.1
 Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr7_-_141168671 0.425 ENSMUST00000106033.3
 Rnh1
ribonuclease/angiogenin inhibitor 1
chr9_+_104002546 0.396 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr10_+_100488289 0.364 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr4_+_11758147 0.347 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr12_+_30584429 0.333 ENSMUST00000057151.8
 Tmem18
transmembrane protein 18
chr3_+_88207308 0.330 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr2_-_13271419 0.289 ENSMUST00000028059.2
 Rsu1
Ras suppressor protein 1
chr2_-_13271268 0.263 ENSMUST00000137670.1
ENSMUST00000114791.2
 Rsu1

Ras suppressor protein 1

chr8_-_4275886 0.263 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr2_-_119029359 0.211 ENSMUST00000110833.1
 Ccdc32
coiled-coil domain containing 32
chr15_-_76206309 0.209 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
 Plec


plectin


chr17_+_40811089 0.206 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr16_-_18235074 0.190 ENSMUST00000076957.5
 Zdhhc8
zinc finger, DHHC domain containing 8
chr17_+_25133385 0.187 ENSMUST00000040729.2
 Clcn7
chloride channel 7
chr7_-_80115294 0.182 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr4_+_133176336 0.179 ENSMUST00000105912.1
 Wasf2
WAS protein family, member 2
chr19_+_46341118 0.166 ENSMUST00000128041.1
 Tmem180
transmembrane protein 180
chr2_-_119029392 0.162 ENSMUST00000036470.7
ENSMUST00000110834.1
 Ccdc32

coiled-coil domain containing 32

chr10_-_78487842 0.124 ENSMUST00000069431.4
 Gm9978
predicted gene 9978
chr7_+_30232310 0.123 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr5_-_62765618 0.120 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_82244716 0.116 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr5_+_21543525 0.111 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr9_-_59353430 0.111 ENSMUST00000026265.6
 Bbs4
Bardet-Biedl syndrome 4 (human)
chr7_-_100855403 0.100 ENSMUST00000156855.1
 Relt
RELT tumor necrosis factor receptor
chr11_-_101987004 0.097 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr14_+_57798156 0.093 ENSMUST00000128764.1
 Sap18
Sin3-associated polypeptide 18
chr17_-_53539411 0.087 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr9_+_119341487 0.071 ENSMUST00000175743.1
ENSMUST00000176397.1
 Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr19_+_55316313 0.070 ENSMUST00000095950.2
 Vti1a
vesicle transport through interaction with t-SNAREs 1A
chr5_+_23787691 0.054 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
 Rint1



RAD50 interactor 1



chr3_+_130068390 0.048 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr5_+_104046869 0.040 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr8_+_71951038 0.037 ENSMUST00000131237.1
ENSMUST00000136516.1
ENSMUST00000109997.2
ENSMUST00000132848.1
 Zfp961



zinc finger protein 961



chr16_+_11203375 0.006 ENSMUST00000181526.1
 2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr11_-_87826023 0.002 ENSMUST00000103177.3
 Lpo
lactoperoxidase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.6 6.2 GO:0051923 sulfation(GO:0051923)
0.3 1.8 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.3 0.8 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 1.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.5 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.6 GO:0046208 spermine catabolic process(GO:0046208)
0.1 1.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.6 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 1.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:1903546 microtubule anchoring at centrosome(GO:0034454) negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) protein localization to photoreceptor outer segment(GO:1903546)
0.0 1.0 GO:0001706 endoderm formation(GO:0001706)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.0 1.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.0 GO:0046032 ADP catabolic process(GO:0046032)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0045098 type III intermediate filament(GO:0045098)
0.2 2.5 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.2 1.8 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 0.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.0 GO:0031513 nonmotile primary cilium(GO:0031513)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.4 2.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.2 0.6 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 1.4 GO:0019215 intermediate filament binding(GO:0019215)
0.1 1.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.4 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 1.9 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.1 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.1 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)