Motif ID: Six6

Z-value: 0.448


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_72939758-0.281.9e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_57455898 0.812 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr11_+_78324200 0.611 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr4_-_43653542 0.599 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr4_-_43653560 0.577 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr5_+_140607334 0.523 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr19_+_4154606 0.456 ENSMUST00000061086.8
 Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr10_+_24595623 0.439 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr13_-_66852017 0.431 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr4_+_156013835 0.427 ENSMUST00000030952.5
 Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chr1_-_165708088 0.414 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr1_+_45311538 0.414 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chrX_+_103414461 0.353 ENSMUST00000033691.4
 Tsx
testis specific X-linked gene
chr4_+_36952930 0.335 ENSMUST00000144029.1
 Gm12371
predicted gene 12371
chr9_+_98422961 0.301 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr11_+_98412461 0.264 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr19_-_23075853 0.234 ENSMUST00000181623.1
 C330002G04Rik
RIKEN cDNA C330002G04 gene
chr2_+_127336152 0.229 ENSMUST00000028846.6
 Dusp2
dual specificity phosphatase 2
chr17_+_40811089 0.223 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr13_-_66851513 0.221 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr8_+_69832633 0.221 ENSMUST00000131637.2
ENSMUST00000081503.6
 Pbx4

pre B cell leukemia homeobox 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0007338 single fertilization(GO:0007338)
0.1 0.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.4 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.4 GO:0051923 sulfation(GO:0051923)
0.1 0.3 GO:0044849 estrous cycle(GO:0044849)
0.1 0.3 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 0.2 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.1 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0043219 lateral loop(GO:0043219)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.0 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.3 GO:0019841 retinol binding(GO:0019841)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.1 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)