Motif ID: Smad1

Z-value: 1.448


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.203.7e-01Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 6.976 ENSMUST00000075312.3
 Ttr
transthyretin
chrX_+_73483602 6.519 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr15_-_66812593 3.662 ENSMUST00000100572.3
 Sla
src-like adaptor
chr2_-_152951547 3.109 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr11_-_55419898 2.561 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr6_+_55336424 2.387 ENSMUST00000004774.3
 Aqp1
aquaporin 1
chr2_-_25470031 2.231 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr18_-_66860458 1.988 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr8_+_104101625 1.955 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr2_-_93452679 1.913 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr12_-_24680890 1.905 ENSMUST00000156453.2
 Cys1
cystin 1
chrX_-_107403295 1.860 ENSMUST00000033591.5
 Itm2a
integral membrane protein 2A
chr2_+_32646586 1.699 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr4_-_133498538 1.664 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr16_-_5222257 1.659 ENSMUST00000050160.4
 AU021092
expressed sequence AU021092
chr10_+_79988584 1.640 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr3_+_94693556 1.502 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr2_-_152951456 1.502 ENSMUST00000123121.2
 Dusp15
dual specificity phosphatase-like 15
chr14_+_65971049 1.469 ENSMUST00000128539.1
 Clu
clusterin
chr3_+_81036360 1.441 ENSMUST00000029652.3
 Pdgfc
platelet-derived growth factor, C polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 660 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 7.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.6 5.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.6 3.6 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.0 3.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 2.7 GO:0015862 uridine transport(GO:0015862)
0.1 2.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 2.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.6 2.5 GO:0071280 cellular response to copper ion(GO:0071280)
0.0 2.5 GO:0006818 hydrogen transport(GO:0006818)
0.5 2.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.5 2.3 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.2 2.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.4 2.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 2.2 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 2.2 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.7 2.0 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.6 1.9 GO:0003032 detection of oxygen(GO:0003032)
0.0 1.9 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.3 1.7 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.3 1.7 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 255 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 34.1 GO:0070062 extracellular exosome(GO:0070062)
0.0 9.8 GO:0030133 transport vesicle(GO:0030133)
0.1 5.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.6 GO:0072562 blood microparticle(GO:0072562)
0.0 4.5 GO:0030027 lamellipodium(GO:0030027)
0.0 4.0 GO:0005768 endosome(GO:0005768)
1.0 3.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.9 GO:0005912 adherens junction(GO:0005912)
0.5 3.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 3.6 GO:0019866 organelle inner membrane(GO:0019866)
0.1 3.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.9 GO:0016324 apical plasma membrane(GO:0016324)
0.7 2.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 2.5 GO:0044391 ribosomal subunit(GO:0044391)
0.6 2.4 GO:0032127 dense core granule membrane(GO:0032127)
0.3 2.4 GO:0097433 dense body(GO:0097433)
0.1 2.3 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 421 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 8.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.9 7.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 4.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.0 3.9 GO:0031720 haptoglobin binding(GO:0031720)
0.2 3.6 GO:0008430 selenium binding(GO:0008430)
0.2 3.5 GO:0051787 misfolded protein binding(GO:0051787)
0.1 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 2.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 2.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.8 2.4 GO:0005534 galactose binding(GO:0005534)
0.2 2.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 2.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 2.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.8 2.3 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.3 2.3 GO:0015168 glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)
0.2 2.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 2.1 GO:0008201 heparin binding(GO:0008201)
0.7 2.0 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.5 2.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)