Motif ID: Smad2

Z-value: 0.352


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241892_76242046-0.252.5e-01Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_57694651 0.675 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr1_-_172297989 0.534 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr5_-_113800356 0.504 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr3_-_116968969 0.461 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr3_-_116968827 0.447 ENSMUST00000119557.1
 Palmd
palmdelphin
chr11_+_63131512 0.397 ENSMUST00000018361.3
 Pmp22
peripheral myelin protein 22
chr18_+_40258361 0.365 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr2_-_148443543 0.356 ENSMUST00000099269.3
 Cd93
CD93 antigen
chr16_+_64851991 0.293 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr4_+_11191726 0.283 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr18_-_42579652 0.265 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr19_+_59458372 0.264 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr6_-_6882068 0.263 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr7_+_82867327 0.230 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr6_+_83137089 0.221 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr4_+_117849193 0.213 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr11_+_69846665 0.209 ENSMUST00000019605.2
 Plscr3
phospholipid scramblase 3
chr4_+_11191354 0.205 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr2_-_91950386 0.201 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr11_+_69846610 0.199 ENSMUST00000152566.1
ENSMUST00000108633.2
 Plscr3

phospholipid scramblase 3

chrX_-_94123359 0.198 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
 Zfx


zinc finger protein X-linked


chr8_-_105637403 0.185 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr13_+_96542727 0.176 ENSMUST00000077672.4
ENSMUST00000109444.2
 Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr14_-_31168587 0.171 ENSMUST00000036618.7
 Stab1
stabilin 1
chr8_-_105637350 0.171 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr6_-_142702259 0.165 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
 Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr15_+_102102926 0.164 ENSMUST00000169627.1
ENSMUST00000046144.9
 Tenc1

tensin like C1 domain-containing phosphatase

chrX_+_99821021 0.156 ENSMUST00000096363.2
 Tmem28
transmembrane protein 28
chr13_-_104816908 0.155 ENSMUST00000022228.6
 Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr8_+_66386292 0.147 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr17_+_7925990 0.145 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr2_-_128967725 0.138 ENSMUST00000099385.2
 Gm10762
predicted gene 10762
chr8_+_110721462 0.128 ENSMUST00000052457.8
 Mtss1l
metastasis suppressor 1-like
chr18_+_37307445 0.128 ENSMUST00000056712.2
 Pcdhb4
protocadherin beta 4
chr13_+_104817171 0.119 ENSMUST00000022230.8
 Srek1ip1
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr14_+_21500879 0.118 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chr17_-_34615965 0.112 ENSMUST00000097345.3
ENSMUST00000015611.7
 Egfl8

EGF-like domain 8

chr15_-_103251465 0.109 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr2_+_177768044 0.107 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr4_+_117849361 0.105 ENSMUST00000163288.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr13_-_78199757 0.105 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr12_+_55836365 0.099 ENSMUST00000059250.6
 Brms1l
breast cancer metastasis-suppressor 1-like
chr7_-_45052865 0.097 ENSMUST00000057293.6
 Prr12
proline rich 12
chr11_+_4135233 0.093 ENSMUST00000124670.1
 Rnf215
ring finger protein 215
chr9_+_44107286 0.092 ENSMUST00000152956.1
ENSMUST00000114815.1
 C1qtnf5

C1q and tumor necrosis factor related protein 5

chr8_-_69184177 0.088 ENSMUST00000185176.1
 Lzts1
leucine zipper, putative tumor suppressor 1
chrX_-_20931520 0.084 ENSMUST00000001156.7
 Cfp
complement factor properdin
chr4_-_155010984 0.083 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr3_+_58576636 0.077 ENSMUST00000107924.1
 Selt
selenoprotein T
chr13_+_23752267 0.071 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr17_-_35700520 0.067 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr10_-_37138863 0.067 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr14_-_20496780 0.066 ENSMUST00000022353.3
 Mss51
MSS51 mitochondrial translational activator
chr18_-_31609893 0.053 ENSMUST00000060396.6
 Slc25a46
solute carrier family 25, member 46
chr10_-_42583628 0.050 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr8_-_70439557 0.036 ENSMUST00000076615.5
 Crtc1
CREB regulated transcription coactivator 1
chr8_-_90908415 0.027 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr10_-_49788743 0.027 ENSMUST00000105483.1
ENSMUST00000105487.1
 Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr3_+_135438722 0.022 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr8_+_109705549 0.019 ENSMUST00000034163.8
 Zfp821
zinc finger protein 821
chr3_+_127633134 0.016 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr16_+_32914094 0.015 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr7_-_34654342 0.015 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr2_+_128967383 0.012 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr17_-_25861456 0.011 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chr18_+_11839220 0.010 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr11_-_69560186 0.005 ENSMUST00000004036.5
 Efnb3
ephrin B3
chr7_+_101321703 0.005 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr11_-_75190458 0.004 ENSMUST00000044949.4
 Dph1
DPH1 homolog (S. cerevisiae)
chr15_+_82252397 0.004 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr14_-_18331855 0.003 ENSMUST00000022296.6
 Ube2e1
ubiquitin-conjugating enzyme E2E 1
chr6_+_125009232 0.001 ENSMUST00000112428.1
 Zfp384
zinc finger protein 384

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.5 GO:1903012 positive regulation of bone development(GO:1903012)
0.1 0.3 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.2 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.1 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0060746 parental behavior(GO:0060746)
0.0 0.1 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.1 GO:0090148 membrane fission(GO:0090148)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.4 GO:0043218 compact myelin(GO:0043218)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.5 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0097001 sphingolipid transporter activity(GO:0046624) ceramide binding(GO:0097001)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)