Motif ID: Smad2

Z-value: 0.352


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241892_76242046-0.252.5e-01Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 72 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_57694651 0.675 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr1_-_172297989 0.534 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr5_-_113800356 0.504 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr3_-_116968969 0.461 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr3_-_116968827 0.447 ENSMUST00000119557.1
 Palmd
palmdelphin
chr11_+_63131512 0.397 ENSMUST00000018361.3
 Pmp22
peripheral myelin protein 22
chr18_+_40258361 0.365 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr2_-_148443543 0.356 ENSMUST00000099269.3
 Cd93
CD93 antigen
chr16_+_64851991 0.293 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr4_+_11191726 0.283 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr18_-_42579652 0.265 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr19_+_59458372 0.264 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr6_-_6882068 0.263 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr7_+_82867327 0.230 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr6_+_83137089 0.221 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr4_+_117849193 0.213 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr11_+_69846665 0.209 ENSMUST00000019605.2
 Plscr3
phospholipid scramblase 3
chr4_+_11191354 0.205 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr2_-_91950386 0.201 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr11_+_69846610 0.199 ENSMUST00000152566.1
ENSMUST00000108633.2
 Plscr3

phospholipid scramblase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.2 0.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 0.5 GO:1903012 positive regulation of bone development(GO:1903012)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.3 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.2 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.1 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.2 GO:0060746 parental behavior(GO:0060746)
0.0 0.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.1 GO:0090148 membrane fission(GO:0090148)

Gene overrepresentation in cellular_component category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.4 GO:0043218 compact myelin(GO:0043218)
0.1 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)

Gene overrepresentation in molecular_function category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.5 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0097001 sphingolipid transporter activity(GO:0046624) ceramide binding(GO:0097001)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)