Motif ID: Smad3

Z-value: 0.736


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_637579940.666.0e-04Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Showing 1 to 20 of 96 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_53707532 4.657 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr1_+_146497614 1.884 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr9_+_53771499 1.822 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr5_+_75574916 1.710 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chr9_+_21196705 1.547 ENSMUST00000003395.9
 Pde4a
phosphodiesterase 4A, cAMP specific
chr9_+_109038565 1.240 ENSMUST00000112059.3
ENSMUST00000026737.5
 Shisa5

shisa homolog 5 (Xenopus laevis)

chr13_-_21750505 1.232 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr13_+_23533869 1.223 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_23551648 1.196 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr13_-_22042949 1.117 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr13_-_21832194 1.059 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr6_-_72235559 1.010 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr9_-_66514567 0.948 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chrX_+_153832225 0.911 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
 Spin2c


spindlin family, member 2C


chr13_-_21833575 0.900 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr18_-_77047243 0.882 ENSMUST00000137354.1
ENSMUST00000137498.1
 Katnal2

katanin p60 subunit A-like 2

chr13_+_22043189 0.851 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr2_+_178193075 0.836 ENSMUST00000103065.1
 Phactr3
phosphatase and actin regulator 3
chr18_-_74207771 0.792 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr13_+_23684192 0.767 ENSMUST00000018246.4
 Hist1h2bc
histone cluster 1, H2bc

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0006342 chromatin silencing(GO:0006342)
0.3 5.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.6 4.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 2.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 1.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.6 1.7 GO:1905065 hematopoietic stem cell migration(GO:0035701) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.1 1.4 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 1.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.3 0.9 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.0 0.8 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.8 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.7 GO:0014047 glutamate secretion(GO:0014047)
0.1 0.6 GO:0046898 response to cycloheximide(GO:0046898)
0.2 0.5 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.5 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.4 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.3 GO:0000786 nucleosome(GO:0000786)
0.0 5.0 GO:0043195 terminal bouton(GO:0043195)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.7 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0042393 histone binding(GO:0042393)
0.1 4.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 2.2 GO:0030552 cAMP binding(GO:0030552)
0.2 1.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 1.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.6 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.4 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.4 GO:0042556 cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.3 GO:0030957 Tat protein binding(GO:0030957)