Motif ID: Smad3

Z-value: 0.736


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_637579940.666.0e-04Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_53707532 4.657 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr1_+_146497614 1.884 ENSMUST00000132847.1
ENSMUST00000166814.1
Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr9_+_53771499 1.822 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr5_+_75574916 1.710 ENSMUST00000144270.1
ENSMUST00000005815.6
Kit

kit oncogene

chr9_+_21196705 1.547 ENSMUST00000003395.9
Pde4a
phosphodiesterase 4A, cAMP specific
chr9_+_109038565 1.240 ENSMUST00000112059.3
ENSMUST00000026737.5
Shisa5

shisa homolog 5 (Xenopus laevis)

chr13_-_21750505 1.232 ENSMUST00000102983.1
Hist1h4k
histone cluster 1, H4k
chr13_+_23533869 1.223 ENSMUST00000073261.2
Hist1h2af
histone cluster 1, H2af
chr13_-_23551648 1.196 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr13_-_22042949 1.117 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_-_21832194 1.059 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr6_-_72235559 1.010 ENSMUST00000042646.7
Atoh8
atonal homolog 8 (Drosophila)
chr9_-_66514567 0.948 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chrX_+_153832225 0.911 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
Spin2c


spindlin family, member 2C


chr13_-_21833575 0.900 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr18_-_77047243 0.882 ENSMUST00000137354.1
ENSMUST00000137498.1
Katnal2

katanin p60 subunit A-like 2

chr13_+_22043189 0.851 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr2_+_178193075 0.836 ENSMUST00000103065.1
Phactr3
phosphatase and actin regulator 3
chr18_-_74207771 0.792 ENSMUST00000040188.8
ENSMUST00000177604.1
Ska1

spindle and kinetochore associated complex subunit 1

chr13_+_23684192 0.767 ENSMUST00000018246.4
Hist1h2bc
histone cluster 1, H2bc
chr13_-_23571151 0.767 ENSMUST00000102969.3
Hist1h2ae
histone cluster 1, H2ae
chrX_+_143664290 0.738 ENSMUST00000112868.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr9_-_106656081 0.729 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr13_+_22035821 0.722 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr14_-_49783327 0.720 ENSMUST00000118129.1
ENSMUST00000036972.6
3632451O06Rik

RIKEN cDNA 3632451O06 gene

chr17_-_31277327 0.716 ENSMUST00000024832.7
Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr1_-_126492683 0.714 ENSMUST00000162877.1
Nckap5
NCK-associated protein 5
chr4_+_102570065 0.689 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr13_+_21735055 0.684 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr13_-_22035589 0.661 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chrX_+_143664365 0.654 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr18_-_77047282 0.648 ENSMUST00000154665.1
ENSMUST00000026486.6
ENSMUST00000123650.1
ENSMUST00000126153.1
Katnal2



katanin p60 subunit A-like 2



chr5_+_114774677 0.643 ENSMUST00000102578.4
Ankrd13a
ankyrin repeat domain 13a
chr13_+_21810428 0.641 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr13_+_23581563 0.631 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr13_+_23531044 0.617 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr1_-_126492900 0.596 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chr2_-_163750169 0.568 ENSMUST00000017841.3
Ada
adenosine deaminase
chr3_+_102734496 0.531 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr13_+_21833736 0.530 ENSMUST00000180288.1
ENSMUST00000110467.1
Hist1h2br

histone cluster 1 H2br

chr13_-_21787218 0.501 ENSMUST00000091751.2
Hist1h2an
histone cluster 1, H2an
chr13_+_23571382 0.484 ENSMUST00000079251.5
Hist1h2bg
histone cluster 1, H2bg
chr1_+_171250416 0.480 ENSMUST00000111315.1
ENSMUST00000006570.5
Adamts4

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4

chr10_-_119240006 0.466 ENSMUST00000020315.6
Cand1
cullin associated and neddylation disassociated 1
chr2_-_152831665 0.450 ENSMUST00000156688.1
ENSMUST00000007803.5
Bcl2l1

BCL2-like 1

chr2_-_127143410 0.440 ENSMUST00000132773.1
Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chrX_-_144688180 0.422 ENSMUST00000040184.3
Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr4_+_45018583 0.408 ENSMUST00000133157.1
ENSMUST00000029999.8
ENSMUST00000107814.3
Polr1e


polymerase (RNA) I polypeptide E


chr7_+_137437591 0.395 ENSMUST00000064404.6
Glrx3
glutaredoxin 3
chr11_-_87828289 0.394 ENSMUST00000136446.1
Lpo
lactoperoxidase
chr4_+_95557494 0.376 ENSMUST00000079223.4
ENSMUST00000177394.1
Fggy

FGGY carbohydrate kinase domain containing

chr13_+_21787461 0.375 ENSMUST00000110473.2
ENSMUST00000102982.1
Hist1h2bp

histone cluster 1, H2bp

chr2_+_129065934 0.374 ENSMUST00000035812.7
Ttl
tubulin tyrosine ligase
chr7_-_100964371 0.373 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr6_+_136808248 0.359 ENSMUST00000074556.4
H2afj
H2A histone family, member J
chr9_-_66593106 0.358 ENSMUST00000127569.1
Usp3
ubiquitin specific peptidase 3
chr7_-_45052865 0.342 ENSMUST00000057293.6
Prr12
proline rich 12
chr13_-_21810190 0.326 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr15_-_58823530 0.312 ENSMUST00000072113.5
Tmem65
transmembrane protein 65
chr1_-_134235420 0.311 ENSMUST00000038191.6
ENSMUST00000086465.4
Adora1

adenosine A1 receptor

chr3_+_107631322 0.300 ENSMUST00000106703.1
Gm10961
predicted gene 10961
chr6_+_129533183 0.299 ENSMUST00000032264.6
Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr12_+_12911986 0.255 ENSMUST00000085720.1
Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr9_-_66593029 0.240 ENSMUST00000098613.2
Usp3
ubiquitin specific peptidase 3
chr7_-_44236098 0.232 ENSMUST00000037220.4
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr13_+_23746734 0.218 ENSMUST00000099703.2
Hist1h2bb
histone cluster 1, H2bb
chr13_-_23683941 0.218 ENSMUST00000171127.1
Hist1h2ac
histone cluster 1, H2ac
chr11_+_58954675 0.195 ENSMUST00000047697.5
ENSMUST00000108817.3
Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr1_+_75210832 0.194 ENSMUST00000027401.4
ENSMUST00000144355.1
ENSMUST00000123825.1
Stk16


serine/threonine kinase 16


chr9_-_66592993 0.176 ENSMUST00000174387.1
Usp3
ubiquitin specific peptidase 3
chr7_+_44384803 0.141 ENSMUST00000120262.1
Syt3
synaptotagmin III
chr11_-_102447647 0.139 ENSMUST00000049057.4
Fam171a2
family with sequence similarity 171, member A2
chr14_+_20348159 0.128 ENSMUST00000090503.4
ENSMUST00000090499.5
ENSMUST00000037698.5
ENSMUST00000051915.6
Fam149b



family with sequence similarity 149, member B



chr12_-_12941827 0.127 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr15_-_81697256 0.124 ENSMUST00000072910.5
Chadl
chondroadherin-like
chr16_-_15594507 0.119 ENSMUST00000115776.1
ENSMUST00000115777.3
Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr2_-_152831112 0.116 ENSMUST00000128172.1
Bcl2l1
BCL2-like 1
chr16_-_15594472 0.116 ENSMUST00000118236.1
ENSMUST00000096234.3
Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr10_+_33905015 0.114 ENSMUST00000169670.1
Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chrX_+_105079761 0.106 ENSMUST00000119477.1
Pbdc1
polysaccharide biosynthesis domain containing 1
chr1_-_23909687 0.096 ENSMUST00000129254.1
Smap1
small ArfGAP 1
chr9_-_60688118 0.094 ENSMUST00000114034.2
ENSMUST00000065603.5
Lrrc49

leucine rich repeat containing 49

chr11_-_26591729 0.094 ENSMUST00000109504.1
Vrk2
vaccinia related kinase 2
chr18_+_31634374 0.064 ENSMUST00000025109.7
Sap130
Sin3A associated protein
chr19_-_23448322 0.063 ENSMUST00000036069.6
Mamdc2
MAM domain containing 2
chr12_+_100779074 0.063 ENSMUST00000110073.1
ENSMUST00000110070.1
9030617O03Rik

RIKEN cDNA 9030617O03 gene

chr9_-_20879718 0.060 ENSMUST00000043726.6
Angptl6
angiopoietin-like 6
chr11_-_103344651 0.058 ENSMUST00000041385.7
Arhgap27
Rho GTPase activating protein 27
chr14_-_62456286 0.057 ENSMUST00000165651.1
ENSMUST00000022501.3
Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr18_+_31634368 0.054 ENSMUST00000178164.1
Sap130
Sin3A associated protein
chr9_-_45936049 0.051 ENSMUST00000034590.2
Tagln
transgelin
chr15_+_81936911 0.036 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr4_+_150281573 0.032 ENSMUST00000105682.2
Rere
arginine glutamic acid dipeptide (RE) repeats
chr18_+_60526194 0.016 ENSMUST00000025505.5
Dctn4
dynactin 4
chr4_+_151089570 0.012 ENSMUST00000105667.2
Gm13090
predicted gene 13090
chr7_+_51880312 0.005 ENSMUST00000145049.1
Gas2
growth arrest specific 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.6 1.7 GO:1905065 hematopoietic stem cell migration(GO:0035701) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.3 0.9 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.3 5.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 0.5 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.6 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.4 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.2 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.1 1.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 2.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.4 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 1.4 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 5.7 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.5 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 1.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.8 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.4 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.7 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.8 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.3 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 0.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 11.3 GO:0000786 nucleosome(GO:0000786)
0.1 0.7 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 5.0 GO:0043195 terminal bouton(GO:0043195)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 1.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 4.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.4 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.1 2.2 GO:0030552 cAMP binding(GO:0030552)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.6 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 6.2 GO:0042393 histone binding(GO:0042393)
0.0 0.4 GO:0042556 cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)