Motif ID: Smad4

Z-value: 0.545


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_73703806-0.029.3e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 193 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_33147400 1.775 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr1_+_153652943 1.116 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr10_+_75589363 0.999 ENSMUST00000072217.2
 Ggt5
gamma-glutamyltransferase 5
chr7_+_101421691 0.942 ENSMUST00000163751.2
ENSMUST00000084894.7
ENSMUST00000166652.1
 Pde2a


phosphodiesterase 2A, cGMP-stimulated


chr10_-_127534540 0.920 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr5_+_120431770 0.855 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5
chr13_-_102958084 0.831 ENSMUST00000099202.3
ENSMUST00000172264.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr14_-_104467984 0.805 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1
chr7_-_70360593 0.745 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr6_+_54039935 0.726 ENSMUST00000114403.1
 Chn2
chimerin (chimaerin) 2
chr6_+_54040078 0.720 ENSMUST00000127323.2
 Chn2
chimerin (chimaerin) 2
chr15_+_89532816 0.631 ENSMUST00000167173.1
 Shank3
SH3/ankyrin domain gene 3
chr9_+_53771499 0.599 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr13_+_21735055 0.548 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr4_-_134254076 0.533 ENSMUST00000060050.5
 Grrp1
glycine/arginine rich protein 1
chr6_+_147032528 0.532 ENSMUST00000036194.4
 Rep15
RAB15 effector protein
chr10_+_80150448 0.526 ENSMUST00000153477.1
 Midn
midnolin
chr7_+_24862193 0.524 ENSMUST00000052897.4
ENSMUST00000170837.2
 Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr3_-_33143227 0.502 ENSMUST00000108219.1
 Pex5l
peroxisomal biogenesis factor 5-like
chr11_-_89302545 0.499 ENSMUST00000061728.3
 Nog
noggin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.8 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 1.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 1.0 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.3 0.9 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 0.9 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0 0.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.9 GO:0006284 base-excision repair(GO:0006284)
0.2 0.8 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223) proprioception(GO:0019230)
0.1 0.7 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.6 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.1 0.6 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.5 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 0.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.5 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.5 GO:0033572 transferrin transport(GO:0033572)
0.2 0.4 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.1 0.4 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0000786 nucleosome(GO:0000786)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 0.9 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.3 GO:0043293 apoptosome(GO:0043293)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.2 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.1 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.8 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 1.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.0 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.3 0.9 GO:0036004 GAF domain binding(GO:0036004)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.2 0.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.4 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 0.4 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0043426 MRF binding(GO:0043426)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)