Motif ID: Snai1_Zeb1_Snai2

Z-value: 1.557

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.521.0e-02Click!
Snai1mm10_v2_chr2_+_167538192_167538210-0.048.6e-01Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.019.5e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_113848615 7.441 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr12_+_82616885 6.332 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr15_-_66831625 4.373 ENSMUST00000164163.1
 Sla
src-like adaptor
chr4_+_85205417 3.863 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr4_+_125490688 3.797 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr5_+_98854434 3.521 ENSMUST00000031278.4
 Bmp3
bone morphogenetic protein 3
chr5_-_147076482 3.074 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr16_+_18776839 2.990 ENSMUST00000043577.1
 Cldn5
claudin 5
chr18_-_61911783 2.783 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr14_-_49525840 2.734 ENSMUST00000138884.1
ENSMUST00000074368.4
ENSMUST00000123534.1
 Slc35f4


solute carrier family 35, member F4


chr4_+_85205120 2.674 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr16_-_52452654 2.564 ENSMUST00000168071.1
 Alcam
activated leukocyte cell adhesion molecule
chr15_+_83791939 2.533 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr11_-_67922136 2.510 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr13_-_57907587 2.398 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr9_+_34486125 2.356 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr7_+_123982799 2.286 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr16_-_52452465 2.227 ENSMUST00000170035.1
ENSMUST00000164728.1
 Alcam

activated leukocyte cell adhesion molecule

chr19_-_57314896 2.204 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr5_+_35057059 2.190 ENSMUST00000050709.3
 Dok7
docking protein 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 874 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.2 6.2 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.2 6.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.4 4.3 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 4.1 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.8 3.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 3.6 GO:0034605 cellular response to heat(GO:0034605)
0.6 3.5 GO:0032796 uropod organization(GO:0032796)
0.4 3.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.4 3.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 3.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
1.0 2.9 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.3 2.9 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 2.9 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 2.9 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 2.8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.7 2.7 GO:0032439 endosome localization(GO:0032439)
0.5 2.7 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.2 2.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.6 2.6 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 298 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 8.3 GO:0005604 basement membrane(GO:0005604)
0.1 6.7 GO:0043195 terminal bouton(GO:0043195)
0.0 6.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.0 GO:0005615 extracellular space(GO:0005615)
0.1 5.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 4.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 4.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 4.0 GO:0042101 T cell receptor complex(GO:0042101)
0.2 3.8 GO:0032279 asymmetric synapse(GO:0032279)
0.1 3.7 GO:0001891 phagocytic cup(GO:0001891)
0.2 3.2 GO:0043196 varicosity(GO:0043196)
0.1 3.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 3.2 GO:0005581 collagen trimer(GO:0005581)
0.2 3.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 3.1 GO:0043209 myelin sheath(GO:0043209)
0.0 3.1 GO:0097060 synaptic membrane(GO:0097060)
0.1 3.0 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 2.9 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 523 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 6.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 6.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.8 5.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 5.4 GO:0005158 insulin receptor binding(GO:0005158)
0.5 5.2 GO:0070700 BMP receptor binding(GO:0070700)
0.1 4.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 4.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 4.4 GO:0005096 GTPase activator activity(GO:0005096)
0.2 4.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 3.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.7 3.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 3.6 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.1 3.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.2 3.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 3.2 GO:0030552 cAMP binding(GO:0030552)
0.2 3.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 3.1 GO:0005518 collagen binding(GO:0005518)