Motif ID: Sox18_Sox12

Z-value: 0.717

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox12mm10_v2_chr2_-_152398046_152398076-0.311.5e-01Click!
Sox18mm10_v2_chr2_-_181671622_181671645-0.009.9e-01Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_67910911 1.199 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr13_+_14063776 1.074 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
 Arid4b




AT rich interactive domain 4B (RBP1-like)




chr2_-_175131864 1.047 ENSMUST00000108929.2
 Gm14399
predicted gene 14399
chr18_+_69344503 1.023 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr9_-_79718631 1.010 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718518 0.997 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718720 0.991 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr18_+_69593361 0.887 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr16_-_91618986 0.860 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr6_-_113934679 0.777 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_55406163 0.765 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr14_+_116925379 0.723 ENSMUST00000088483.3
 Gpc6
glypican 6
chr2_-_59948155 0.722 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr5_+_14514918 0.719 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr10_-_62792243 0.697 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr14_+_62837679 0.685 ENSMUST00000014691.8
 Wdfy2
WD repeat and FYVE domain containing 2
chr17_+_21555046 0.680 ENSMUST00000079242.3
 Zfp52
zinc finger protein 52
chr10_-_53647080 0.675 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr1_-_119837613 0.637 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr1_+_165788681 0.628 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0042118 endothelial cell activation(GO:0042118)
0.0 1.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 1.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.8 GO:0048840 otolith development(GO:0048840)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.7 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 0.6 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.6 GO:0006308 DNA catabolic process(GO:0006308)
0.2 0.5 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.5 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 0.4 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.4 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.0 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 1.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.9 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.9 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.1 0.5 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.1 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.2 0.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.1 0.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 0.5 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.4 GO:0043237 laminin-1 binding(GO:0043237)