Motif ID: Sox2

Z-value: 2.323


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_34650005-0.491.9e-02Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_49636847 11.908 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr1_+_6734827 8.961 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr4_+_62965560 8.600 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr1_-_138842429 7.383 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr10_+_26229707 7.272 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6487231 6.885 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr6_-_23248264 6.751 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_115824699 6.079 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr10_+_94036001 5.567 ENSMUST00000020208.4
 Fgd6
FYVE, RhoGEF and PH domain containing 6
chr1_+_6730051 5.244 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr11_-_96005872 5.181 ENSMUST00000013559.2
 Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chrX_-_143933089 5.180 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_64122256 5.019 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr1_+_66322102 4.914 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chrX_+_143518671 4.759 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr9_+_102718424 4.687 ENSMUST00000156485.1
ENSMUST00000145937.1
ENSMUST00000134483.1
 Amotl2


angiomotin-like 2


chr7_-_103853199 4.685 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr12_-_31713873 4.664 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
 Gpr22


G protein-coupled receptor 22


chr10_-_29144194 4.584 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr6_+_47244359 4.450 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 414 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.0 GO:0001578 microtubule bundle formation(GO:0001578)
1.1 12.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.0 12.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 11.1 GO:0035329 hippo signaling(GO:0035329)
0.6 10.4 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715)
0.5 8.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
2.6 7.9 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
1.5 7.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 7.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.8 7.1 GO:0035881 amacrine cell differentiation(GO:0035881)
1.4 7.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.1 6.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 6.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 6.7 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
1.3 6.5 GO:0015671 oxygen transport(GO:0015671)
0.2 6.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.3 6.1 GO:0035855 megakaryocyte development(GO:0035855)
0.8 5.9 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
1.2 5.8 GO:0065001 specification of axis polarity(GO:0065001)
0.6 5.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 96.0 GO:0005634 nucleus(GO:0005634)
0.1 14.8 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2 13.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 13.3 GO:0005667 transcription factor complex(GO:0005667)
0.3 11.5 GO:0090544 BAF-type complex(GO:0090544)
1.2 11.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 7.7 GO:0044295 axonal growth cone(GO:0044295)
1.2 7.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 7.2 GO:0016605 PML body(GO:0016605)
0.0 7.1 GO:0005874 microtubule(GO:0005874)
0.8 6.5 GO:0005833 hemoglobin complex(GO:0005833)
0.3 5.8 GO:0031430 M band(GO:0031430)
0.3 5.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.7 5.7 GO:0033269 internode region of axon(GO:0033269)
0.3 5.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 5.5 GO:0005871 kinesin complex(GO:0005871)
0.1 5.2 GO:0042641 actomyosin(GO:0042641)
0.2 5.1 GO:0030673 axolemma(GO:0030673)
0.3 5.0 GO:0035102 PRC1 complex(GO:0035102)
0.1 4.8 GO:0001772 immunological synapse(GO:0001772)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 262 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 79.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 40.2 GO:0003677 DNA binding(GO:0003677)
0.0 18.4 GO:0044822 poly(A) RNA binding(GO:0044822)
0.2 14.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 12.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 11.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 11.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.0 9.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 9.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.4 9.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.8 8.3 GO:0030957 Tat protein binding(GO:0030957)
0.9 7.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 7.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 7.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 6.7 GO:0008017 microtubule binding(GO:0008017)
1.3 6.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 6.3 GO:0070410 co-SMAD binding(GO:0070410)
0.2 6.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 5.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 5.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)