Motif ID: Sox21

Z-value: 0.629


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_118237035-0.242.7e-01Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_109993982 1.921 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr12_+_38783503 1.884 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr18_-_34007206 1.561 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chr1_+_107511416 1.502 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr2_-_72986716 1.500 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr10_-_116972609 1.343 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chrM_+_14138 1.172 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr9_-_73968901 1.000 ENSMUST00000184666.1
 Unc13c
unc-13 homolog C (C. elegans)
chrM_-_14060 0.998 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr7_+_51621830 0.934 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr3_-_33082004 0.796 ENSMUST00000108225.3
 Pex5l
peroxisomal biogenesis factor 5-like
chr6_+_120666388 0.789 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr8_-_57652993 0.703 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr4_+_139923349 0.675 ENSMUST00000128563.1
 Gm13028
predicted gene 13028
chr1_-_150465563 0.674 ENSMUST00000164600.1
ENSMUST00000111902.2
ENSMUST00000111901.2
ENSMUST00000006171.9
 Prg4



proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)



chr10_+_42860776 0.643 ENSMUST00000105494.1
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr19_+_44493472 0.635 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr11_+_69045640 0.596 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chrX_-_75578188 0.515 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr7_-_25675047 0.504 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
 Tmem91


transmembrane protein 91



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 1.2 GO:0033762 response to glucagon(GO:0033762)
0.2 1.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.9 GO:0001504 neurotransmitter uptake(GO:0001504)
0.1 0.8 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.8 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.8 GO:0001842 neural fold formation(GO:0001842)
0.2 0.7 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 0.6 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.2 0.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.5 GO:0070295 renal water absorption(GO:0070295)
0.0 0.5 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909)
0.0 0.4 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1 0.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.3 GO:0032460 negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463)
0.0 0.3 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 1.1 GO:0070469 respiratory chain(GO:0070469)
0.0 0.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 0.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.8 GO:0090537 CERF complex(GO:0090537)
0.1 0.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 1.0 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.0 0.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.2 0.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.7 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 0.6 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.6 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 0.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.1 0.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.3 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)