Motif ID: Sox3_Sox10

Z-value: 1.194

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox10mm10_v2_chr15_-_79164477_79164496-0.795.9e-06Click!
Sox3mm10_v2_chrX_-_60893430_608934400.744.7e-05Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_49636847 7.622 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr6_-_23248264 6.632 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_+_26229707 4.404 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr13_-_56252163 4.315 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr18_-_47333311 4.302 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr12_-_31713873 4.265 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
 Gpr22


G protein-coupled receptor 22


chr11_+_67586675 4.075 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr6_+_47244359 3.982 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr1_+_6734827 3.879 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr11_+_67586520 3.520 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr6_+_17065129 3.441 ENSMUST00000115467.4
ENSMUST00000154266.2
ENSMUST00000076654.7
 Tes


testis derived transcript


chr2_+_13573927 3.428 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr5_+_148265265 3.372 ENSMUST00000071878.5
 Mtus2
microtubule associated tumor suppressor candidate 2
chr11_-_96005872 3.153 ENSMUST00000013559.2
 Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chr5_+_148265307 3.120 ENSMUST00000110514.1
 Mtus2
microtubule associated tumor suppressor candidate 2
chr1_+_66322102 3.041 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr1_-_138842429 2.912 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr6_+_51432663 2.906 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr6_+_51432678 2.902 ENSMUST00000160133.1
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr7_+_29309429 2.872 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 335 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.5 7.9 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.4 7.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.1 6.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 5.8 GO:0051017 actin filament bundle assembly(GO:0051017)
0.3 5.5 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715)
0.1 4.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.5 4.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.6 4.3 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.8 4.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.6 4.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.8 4.0 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)
0.8 3.9 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.2 3.9 GO:0045760 positive regulation of action potential(GO:0045760)
0.5 3.8 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.5 3.8 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 3.6 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.2 3.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.7 3.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.4 3.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 9.5 GO:0071565 nBAF complex(GO:0071565)
0.1 9.1 GO:0043204 perikaryon(GO:0043204)
0.1 7.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8 7.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 6.5 GO:0005884 actin filament(GO:0005884)
0.2 6.2 GO:0043034 costamere(GO:0043034)
0.1 5.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 3.8 GO:0016363 nuclear matrix(GO:0016363)
0.2 3.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.9 3.4 GO:0045098 type III intermediate filament(GO:0045098)
0.6 3.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 3.3 GO:0031941 filamentous actin(GO:0031941)
0.0 3.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.0 GO:0030496 midbody(GO:0030496)
0.0 2.9 GO:0030424 axon(GO:0030424)
0.5 2.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 2.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.3 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.0 GO:0008270 zinc ion binding(GO:0008270)
0.1 7.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 7.5 GO:0008017 microtubule binding(GO:0008017)
0.2 7.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 6.4 GO:0051015 actin filament binding(GO:0051015)
0.0 6.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.8 6.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 4.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 3.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.4 3.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 3.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 3.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 3.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.8 3.2 GO:1990254 keratin filament binding(GO:1990254)
0.2 3.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 3.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 3.2 GO:0042277 peptide binding(GO:0042277)
0.1 3.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.3 3.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)