Motif ID: Sox6_Sox9

Z-value: 0.822

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_1127822480.547.9e-03Click!
Sox6mm10_v2_chr7_-_116038734_116038750-0.048.5e-01Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 4.001 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr13_-_97747399 3.321 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_-_106715251 3.171 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr13_-_97747373 3.027 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr5_+_66968416 2.660 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr5_+_66968559 2.476 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr6_+_17463749 2.365 ENSMUST00000115443.1
 Met
met proto-oncogene
chr1_-_155146755 2.322 ENSMUST00000027744.8
 Mr1
major histocompatibility complex, class I-related
chr9_-_79718631 2.217 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr5_+_3344194 2.152 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr9_-_79718518 2.072 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718720 1.937 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr7_+_96210107 1.891 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr3_-_116129615 1.831 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr8_-_11312731 1.824 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr2_+_180598219 1.795 ENSMUST00000103059.1
 Col9a3
collagen, type IX, alpha 3
chr12_+_29528382 1.792 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr5_+_3343893 1.783 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr2_-_33942111 1.720 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr1_-_56972437 1.704 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.9 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.7 4.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 4.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.3 3.9 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
1.1 3.3 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.8 3.2 GO:0050904 diapedesis(GO:0050904)
0.0 3.1 GO:0007018 microtubule-based movement(GO:0007018)
0.1 2.3 GO:0032620 interleukin-17 production(GO:0032620)
0.6 2.2 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 2.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 2.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.5 1.9 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.3 1.8 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.2 1.8 GO:0061032 visceral serous pericardium development(GO:0061032)
0.2 1.7 GO:0021546 rhombomere development(GO:0021546)
0.2 1.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 1.6 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 1.6 GO:0061042 vascular wound healing(GO:0061042)
0.1 1.5 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.4 1.4 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 6.2 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
1.2 4.9 GO:0097165 nuclear stress granule(GO:0097165)
0.1 4.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 3.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.6 3.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.6 2.8 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 2.8 GO:0005871 kinesin complex(GO:0005871)
0.0 2.7 GO:0043235 receptor complex(GO:0043235)
0.2 2.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.4 1.8 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 1.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 1.5 GO:0044307 dendritic branch(GO:0044307)
0.3 1.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.0 1.3 GO:0000922 spindle pole(GO:0000922)
0.1 1.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 1.0 GO:0000138 Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 4.8 GO:0030332 cyclin binding(GO:0030332)
1.1 4.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 3.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 3.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 2.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 2.5 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.9 GO:0035497 cAMP response element binding(GO:0035497)
0.5 1.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.6 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 1.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.4 GO:0030507 spectrin binding(GO:0030507)