Motif ID: Sox8

Z-value: 0.417


Transcription factors associated with Sox8:

Gene SymbolEntrez IDGene Name
Sox8 ENSMUSG00000024176.4 Sox8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_25570694-0.771.7e-05Click!


Activity profile for motif Sox8.

activity profile for motif Sox8


Sorted Z-values histogram for motif Sox8

Sorted Z-values for motif Sox8



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_8667033 1.777 ENSMUST00000042412.3
Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr18_-_62741387 1.034 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr3_+_102010138 0.994 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr11_+_97415527 0.871 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chrX_+_134404780 0.830 ENSMUST00000113224.2
ENSMUST00000113226.1
Drp2

dystrophin related protein 2

chr13_-_19395728 0.828 ENSMUST00000039694.7
Stard3nl
STARD3 N-terminal like
chr19_+_24875679 0.732 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr7_-_126800354 0.700 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr13_-_66852017 0.688 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr1_+_109983737 0.681 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chr1_+_109993982 0.666 ENSMUST00000027542.6
Cdh7
cadherin 7, type 2
chr7_-_126800036 0.610 ENSMUST00000133514.1
ENSMUST00000151137.1
Aldoa

aldolase A, fructose-bisphosphate

chr10_-_128180265 0.575 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr11_+_69991633 0.571 ENSMUST00000108592.1
Gabarap
gamma-aminobutyric acid receptor associated protein
chr8_+_34807287 0.518 ENSMUST00000033930.4
Dusp4
dual specificity phosphatase 4
chr4_-_58553553 0.474 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
Lpar1


lysophosphatidic acid receptor 1


chr13_-_66227573 0.415 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr14_-_49783327 0.411 ENSMUST00000118129.1
ENSMUST00000036972.6
3632451O06Rik

RIKEN cDNA 3632451O06 gene

chr15_-_103215285 0.382 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
Cbx5


chromobox 5


chrX_-_23285532 0.352 ENSMUST00000115319.2
Klhl13
kelch-like 13
chr11_+_69991061 0.351 ENSMUST00000018711.8
Gabarap
gamma-aminobutyric acid receptor associated protein
chr15_-_97020322 0.348 ENSMUST00000166223.1
Slc38a4
solute carrier family 38, member 4
chr13_+_93304799 0.323 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chrX_-_72918284 0.300 ENSMUST00000152200.1
Cetn2
centrin 2
chr11_-_110095937 0.297 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr11_-_43747963 0.246 ENSMUST00000048578.2
ENSMUST00000109278.1
Ttc1

tetratricopeptide repeat domain 1

chr4_-_129578535 0.241 ENSMUST00000052835.8
Fam167b
family with sequence similarity 167, member B
chr11_+_113659283 0.228 ENSMUST00000137878.1
Cog1
component of oligomeric golgi complex 1
chr11_-_110095974 0.212 ENSMUST00000100287.2
Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr18_+_36952621 0.202 ENSMUST00000115661.2
Pcdha2
protocadherin alpha 2
chr9_-_95815389 0.199 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chr13_+_93304066 0.195 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr15_-_89149557 0.164 ENSMUST00000088823.3
Mapk11
mitogen-activated protein kinase 11
chr2_+_69789647 0.157 ENSMUST00000112266.1
Phospho2
phosphatase, orphan 2
chr13_-_66851513 0.142 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr4_+_43401232 0.124 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr2_-_37647199 0.120 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein
chr2_+_69789621 0.116 ENSMUST00000151298.1
ENSMUST00000028494.2
Phospho2

phosphatase, orphan 2

chr7_-_42578588 0.102 ENSMUST00000179470.1
Gm21028
predicted gene, 21028
chr8_-_33747724 0.097 ENSMUST00000179364.1
Smim18
small integral membrane protein 18
chr16_-_29541483 0.095 ENSMUST00000057018.8
ENSMUST00000182627.1
Atp13a4

ATPase type 13A4

chrX_-_162643629 0.090 ENSMUST00000112334.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr18_+_80046854 0.061 ENSMUST00000070219.7
Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr11_-_26591729 0.049 ENSMUST00000109504.1
Vrk2
vaccinia related kinase 2
chrX_-_162643575 0.048 ENSMUST00000101102.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr9_-_4309432 0.048 ENSMUST00000051589.7
Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr4_-_134245579 0.046 ENSMUST00000030644.7
Zfp593
zinc finger protein 593
chr11_+_32286946 0.029 ENSMUST00000101387.3
Hbq1b
hemoglobin, theta 1B
chr4_+_154142363 0.028 ENSMUST00000030895.5
Wrap73
WD repeat containing, antisense to Trp73

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.2 1.0 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.9 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.2 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.0 0.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.2 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.0 GO:0006553 lysine metabolic process(GO:0006553)
0.0 1.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.3 GO:0071942 XPC complex(GO:0071942)
0.1 0.9 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0035939 microsatellite binding(GO:0035939)
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.3 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 0.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 1.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)