Motif ID: Sp1

Z-value: 2.333


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_1024063800.359.8e-02Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_172345565 15.884 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr1_-_56971762 14.424 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr5_+_134986191 14.410 ENSMUST00000094245.2
 Cldn3
claudin 3
chr8_-_84800024 13.433 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr12_+_70825492 12.372 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr14_-_25769033 11.740 ENSMUST00000069180.7
 Zcchc24
zinc finger, CCHC domain containing 24
chr17_+_83215271 11.123 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr8_-_29219338 10.995 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr18_+_24709436 10.928 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr4_-_154636831 10.886 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr16_-_22439719 10.729 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr5_-_134747241 10.534 ENSMUST00000015138.9
 Eln
elastin
chr18_+_64340225 10.370 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr1_-_56972437 9.880 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr1_+_42697146 9.233 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr4_-_22488296 9.204 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr8_-_84800344 9.155 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr15_+_81811414 9.073 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chrX_+_99975570 8.750 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
 Eda








ectodysplasin-A








chr15_-_58076456 8.715 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,152 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 27.4 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.6 24.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9 18.6 GO:0046033 AMP metabolic process(GO:0046033)
1.5 17.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
2.1 17.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.5 17.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
2.1 17.0 GO:0032429 regulation of phospholipase A2 activity(GO:0032429)
1.2 16.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
2.3 16.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
3.9 15.8 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.1 15.4 GO:0009437 carnitine metabolic process(GO:0009437)
1.7 13.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
4.5 13.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.5 13.3 GO:0042118 endothelial cell activation(GO:0042118)
3.3 13.2 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.8 13.0 GO:0009950 dorsal/ventral axis specification(GO:0009950)
4.3 12.8 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.7 12.6 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.6 12.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.9 12.4 GO:0021859 pyramidal neuron differentiation(GO:0021859)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 350 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 132.2 GO:0016021 integral component of membrane(GO:0016021)
0.2 48.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.4 37.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 35.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 31.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 30.9 GO:0005667 transcription factor complex(GO:0005667)
0.2 30.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 30.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 21.7 GO:0005924 cell-substrate adherens junction(GO:0005924) cell-substrate junction(GO:0030055)
0.2 21.6 GO:0001726 ruffle(GO:0001726)
0.3 20.9 GO:0030175 filopodium(GO:0030175)
1.0 20.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 15.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.6 15.2 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
0.4 14.8 GO:0044298 cell body membrane(GO:0044298)
0.7 14.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.7 14.4 GO:0005581 collagen trimer(GO:0005581)
0.1 14.3 GO:0005740 mitochondrial envelope(GO:0005740)
1.1 13.8 GO:0043205 fibril(GO:0043205)
1.5 13.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 645 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 47.2 GO:0051015 actin filament binding(GO:0051015)
0.9 33.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
1.0 31.5 GO:0071837 HMG box domain binding(GO:0071837)
0.2 31.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 29.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 26.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 25.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.5 25.1 GO:0005003 ephrin receptor activity(GO:0005003)
1.0 23.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.8 22.4 GO:0070412 R-SMAD binding(GO:0070412)
0.5 20.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 19.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 18.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.8 17.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
1.0 17.4 GO:0017166 vinculin binding(GO:0017166)
0.3 16.9 GO:0005178 integrin binding(GO:0005178)
0.3 16.4 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.3 15.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
1.0 14.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
3.5 14.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)