Motif ID: Spdef

Z-value: 0.604


Transcription factors associated with Spdef:

Gene SymbolEntrez IDGene Name
Spdef ENSMUSG00000024215.7 Spdef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spdefmm10_v2_chr17_-_27728889_277289560.252.6e-01Click!


Activity profile for motif Spdef.

activity profile for motif Spdef


Sorted Z-values histogram for motif Spdef

Sorted Z-values for motif Spdef



Network of associatons between targets according to the STRING database.



First level regulatory network of Spdef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_58813359 4.270 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr18_+_34861200 2.050 ENSMUST00000165033.1
 Egr1
early growth response 1
chr8_+_125995102 1.310 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr2_-_167492826 1.194 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr1_-_56969864 1.182 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr14_+_28511344 1.168 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr15_-_89170688 1.061 ENSMUST00000060808.9
 Plxnb2
plexin B2
chr1_-_56969827 1.019 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr9_+_80165079 0.989 ENSMUST00000184480.1
 Myo6
myosin VI
chr5_+_66968559 0.973 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_66968961 0.967 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr5_+_111733924 0.961 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr9_+_65908967 0.910 ENSMUST00000034949.3
ENSMUST00000154589.1
 Csnk1g1

casein kinase 1, gamma 1

chr15_-_99820072 0.898 ENSMUST00000109024.2
 Lima1
LIM domain and actin binding 1
chr3_-_84582616 0.894 ENSMUST00000143514.1
 Arfip1
ADP-ribosylation factor interacting protein 1
chr9_+_80165013 0.893 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr9_-_65908676 0.837 ENSMUST00000119245.1
ENSMUST00000134338.1
ENSMUST00000179395.1
 Trip4


thyroid hormone receptor interactor 4


chr14_-_70207637 0.830 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr13_-_21531032 0.806 ENSMUST00000156674.2
ENSMUST00000110481.2
 Zkscan8

zinc finger with KRAB and SCAN domains 8

chr3_-_84582476 0.801 ENSMUST00000107687.2
ENSMUST00000098990.3
 Arfip1

ADP-ribosylation factor interacting protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.7 2.1 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 1.9 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 1.9 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 1.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.3 1.3 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.4 1.2 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.2 1.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.2 1.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 1.1 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 1.1 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.3 1.0 GO:0019085 early viral transcription(GO:0019085)
0.3 1.0 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.2 1.0 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.3 0.8 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.8 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.8 GO:0003281 ventricular septum development(GO:0003281)
0.1 0.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 0.7 GO:0006691 leukotriene metabolic process(GO:0006691)
0.0 0.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.5 GO:0031526 brush border membrane(GO:0031526)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.1 1.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 1.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.0 GO:0000322 storage vacuole(GO:0000322)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 0.8 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.5 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.3 GO:0051015 actin filament binding(GO:0051015)
0.1 1.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 1.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 1.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.4 1.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.1 GO:0050681 androgen receptor binding(GO:0050681)
0.2 1.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.2 1.0 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 1.0 GO:0017166 vinculin binding(GO:0017166)
0.0 1.0 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.9 GO:0005131 growth hormone receptor binding(GO:0005131)
0.2 0.8 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.8 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.1 0.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.1 0.7 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)