Motif ID: Spic

Z-value: 0.898


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.087.2e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 3.612 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr11_+_78324200 3.105 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr1_-_56978534 3.093 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_-_136886187 2.767 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr8_-_122432924 2.278 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr11_-_106715251 2.232 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr14_+_80000292 1.982 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr4_-_118489755 1.959 ENSMUST00000184261.1
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr12_+_75308308 1.875 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr1_-_171234290 1.729 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr4_+_130913120 1.702 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr15_-_66812593 1.680 ENSMUST00000100572.3
 Sla
src-like adaptor
chr6_+_5725639 1.646 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chrX_+_8271133 1.608 ENSMUST00000127103.1
ENSMUST00000115591.1
 Slc38a5

solute carrier family 38, member 5

chr4_+_130913264 1.533 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr3_+_95526777 1.423 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr6_-_48708206 1.239 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr2_-_167492826 1.216 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr6_+_125215551 1.211 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
 Vamp1


vesicle-associated membrane protein 1


chr4_-_147936713 1.156 ENSMUST00000105712.1
ENSMUST00000019199.7
 Plod1

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.3 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.3 3.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 3.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 2.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.4 GO:0051291 protein heterooligomerization(GO:0051291)
0.8 2.3 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.8 2.3 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.6 2.2 GO:0050904 diapedesis(GO:0050904)
0.1 2.1 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 2.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 2.0 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 1.9 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 1.9 GO:0045026 plasma membrane fusion(GO:0045026)
0.1 1.8 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 1.8 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.2 1.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.3 1.6 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 1.6 GO:0015816 glycine transport(GO:0015816)
0.2 1.4 GO:0071569 protein ufmylation(GO:0071569)
0.1 1.4 GO:0010447 response to acidic pH(GO:0010447)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 GO:0005581 collagen trimer(GO:0005581)
0.0 3.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 3.2 GO:0042581 specific granule(GO:0042581)
0.0 3.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4 2.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.5 1.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.5 GO:0097440 apical dendrite(GO:0097440)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 1.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 1.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 1.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.0 GO:0033263 CORVET complex(GO:0033263)
0.1 0.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.9 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.6 GO:0043394 proteoglycan binding(GO:0043394)
0.5 2.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 2.0 GO:0045296 cadherin binding(GO:0045296)
0.0 2.0 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 1.8 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 1.8 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.1 1.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.6 1.7 GO:0019863 IgE binding(GO:0019863)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 1.6 GO:0045503 dynein light chain binding(GO:0045503)
0.2 1.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 1.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 1.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)