Motif ID: Srf

Z-value: 1.159


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_46556188-0.443.6e-02Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 13.256 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr7_-_137314394 4.881 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr10_-_120899067 4.273 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr4_+_43957678 3.792 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr1_-_127677923 3.653 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr4_+_43957401 3.603 ENSMUST00000030202.7
Glipr2
GLI pathogenesis-related 2
chr5_-_24329556 2.545 ENSMUST00000115098.2
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr13_+_51846673 2.503 ENSMUST00000021903.2
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr4_-_63403330 2.479 ENSMUST00000035724.4
Akna
AT-hook transcription factor
chr19_+_53529100 2.437 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5
chr14_+_5071040 2.213 ENSMUST00000163719.1
Gm8281
predicted gene, 8281
chr14_+_4415448 2.030 ENSMUST00000168866.1
Gm3164
predicted gene 3164
chr4_+_137862237 2.030 ENSMUST00000102518.3
Ece1
endothelin converting enzyme 1
chr11_+_94741782 1.736 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr14_-_6038209 1.716 ENSMUST00000164139.1
Gm8206
predicted gene 8206
chr14_+_3049285 1.673 ENSMUST00000166494.1
Gm2897
predicted gene 2897
chr14_+_4726775 1.616 ENSMUST00000165619.1
Gm3252
predicted gene 3252
chr14_-_5961745 1.609 ENSMUST00000163885.1
Gm3248
predicted gene 3248
chr14_+_3652030 1.567 ENSMUST00000167430.1
Gm3020
predicted gene 3020
chr14_-_6889962 1.561 ENSMUST00000171906.1
Gm3667
predicted gene 3667
chr14_-_7568566 1.556 ENSMUST00000163790.1
Gm3558
predicted gene 3558
chr14_-_5389049 1.542 ENSMUST00000177986.1
Gm3500
predicted gene 3500
chr14_-_7027449 1.528 ENSMUST00000170738.2
Gm10406
predicted gene 10406
chr2_-_60881360 1.517 ENSMUST00000164147.1
ENSMUST00000112509.1
Rbms1

RNA binding motif, single stranded interacting protein 1

chr14_-_5880382 1.517 ENSMUST00000164484.1
Gm8237
predicted gene 8237
chr14_+_4334763 1.511 ENSMUST00000165466.1
2610042L04Rik
RIKEN cDNA 2610042L04 gene
chr14_-_6287250 1.509 ENSMUST00000170104.2
Gm3411
predicted gene 3411
chr10_-_12861735 1.502 ENSMUST00000076817.4
Utrn
utrophin
chr19_-_4928241 1.489 ENSMUST00000025851.3
Dpp3
dipeptidylpeptidase 3
chr14_+_4182576 1.487 ENSMUST00000164512.1
Gm2974
predicted gene 2974
chr14_+_3332627 1.470 ENSMUST00000177786.1
Gm2956
predicted gene 2956
chr14_+_3572023 1.390 ENSMUST00000178728.1
Gm3005
predicted gene 3005
chr14_+_3412614 1.340 ENSMUST00000170123.1
Gm10409
predicted gene 10409
chr7_+_101896340 1.319 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr14_-_7315049 1.308 ENSMUST00000165744.1
Gm3739
predicted gene 3739
chr14_-_7174533 1.303 ENSMUST00000172431.1
Gm3512
predicted gene 3512
chr2_-_152415044 1.270 ENSMUST00000099207.3
Zcchc3
zinc finger, CCHC domain containing 3
chr14_+_3810074 1.225 ENSMUST00000170480.1
Gm3002
predicted gene 3002
chr14_+_5501674 1.203 ENSMUST00000181562.1
Gm3488
predicted gene, 3488
chr4_+_148000722 1.155 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr11_-_120348513 1.129 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr14_-_5741577 1.111 ENSMUST00000177556.1
Gm3373
predicted gene 3373
chr8_-_84237042 1.101 ENSMUST00000039480.5
Zswim4
zinc finger SWIM-type containing 4
chr19_+_25406661 1.098 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr1_+_167618246 1.094 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr11_-_120348091 1.076 ENSMUST00000106215.4
Actg1
actin, gamma, cytoplasmic 1
chr5_+_90367204 1.034 ENSMUST00000068250.3
Gm9958
predicted gene 9958
chr14_+_4110526 1.030 ENSMUST00000170207.1
Gm8108
predicted gene 8108
chr4_+_132351768 1.014 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr5_-_138996087 1.013 ENSMUST00000110897.1
Pdgfa
platelet derived growth factor, alpha
chr14_-_6108665 0.981 ENSMUST00000165193.1
Gm3468
predicted gene 3468
chr11_-_120348475 0.926 ENSMUST00000062147.7
ENSMUST00000128055.1
Actg1

actin, gamma, cytoplasmic 1

chr8_-_47675130 0.903 ENSMUST00000080353.2
Ing2
inhibitor of growth family, member 2
chr7_+_101896817 0.903 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr9_-_66514567 0.902 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr19_-_5912771 0.880 ENSMUST00000118623.1
Dpf2
D4, zinc and double PHD fingers family 2
chr8_-_47675556 0.855 ENSMUST00000125536.1
Ing2
inhibitor of growth family, member 2
chr1_+_38987806 0.826 ENSMUST00000027247.5
Pdcl3
phosducin-like 3
chr14_+_4855576 0.811 ENSMUST00000166776.1
Gm3264
predicted gene 3264
chr3_+_90072641 0.793 ENSMUST00000121503.1
ENSMUST00000119570.1
ENSMUST00000062193.9
Tpm3


tropomyosin 3, gamma


chr7_+_128246953 0.786 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr7_+_128246812 0.777 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr5_-_145191511 0.776 ENSMUST00000161845.1
Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr3_-_152266320 0.745 ENSMUST00000046045.8
Nexn
nexilin
chr19_-_5912834 0.724 ENSMUST00000136983.1
Dpf2
D4, zinc and double PHD fingers family 2
chr2_+_143915273 0.688 ENSMUST00000103172.3
Dstn
destrin
chr10_+_4266323 0.685 ENSMUST00000045730.5
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr10_+_67537861 0.671 ENSMUST00000048289.7
ENSMUST00000105438.2
ENSMUST00000130933.1
ENSMUST00000146986.1
Egr2



early growth response 2



chr3_+_131112785 0.639 ENSMUST00000098611.3
Lef1
lymphoid enhancer binding factor 1
chr6_+_113378113 0.639 ENSMUST00000171058.1
ENSMUST00000156898.1
Arpc4

actin related protein 2/3 complex, subunit 4

chr8_-_123894736 0.625 ENSMUST00000034453.4
Acta1
actin, alpha 1, skeletal muscle
chr11_+_82911253 0.613 ENSMUST00000164945.1
ENSMUST00000018989.7
Unc45b

unc-45 homolog B (C. elegans)

chr10_-_111997204 0.602 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr6_-_113377510 0.597 ENSMUST00000099118.2
Tada3
transcriptional adaptor 3
chr2_+_125068118 0.587 ENSMUST00000070353.3
Slc24a5
solute carrier family 24, member 5
chr11_+_77462325 0.567 ENSMUST00000102493.1
Coro6
coronin 6
chr1_-_131097535 0.564 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr15_-_36794498 0.557 ENSMUST00000110361.1
ENSMUST00000022894.7
ENSMUST00000110359.1
Ywhaz


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide


chr7_-_44997535 0.515 ENSMUST00000124232.1
ENSMUST00000003290.4
Bcl2l12

BCL2-like 12 (proline rich)

chr4_-_132351636 0.510 ENSMUST00000105951.1
Rcc1
regulator of chromosome condensation 1
chr12_-_32953772 0.504 ENSMUST00000180391.1
ENSMUST00000181670.1
4933406C10Rik

RIKEN cDNA 4933406C10 gene

chrX_+_101449078 0.503 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr14_+_74732384 0.475 ENSMUST00000176957.1
Esd
esterase D/formylglutathione hydrolase
chr6_-_113377376 0.463 ENSMUST00000043333.2
Tada3
transcriptional adaptor 3
chr14_-_19585135 0.445 ENSMUST00000170694.1
Gm2237
predicted gene 2237
chr12_-_110696289 0.421 ENSMUST00000021698.6
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr7_+_44997648 0.408 ENSMUST00000003284.8
ENSMUST00000107835.1
Irf3

interferon regulatory factor 3

chr10_+_45335751 0.333 ENSMUST00000095715.3
Bves
blood vessel epicardial substance
chr5_+_30588078 0.310 ENSMUST00000066295.2
Kcnk3
potassium channel, subfamily K, member 3
chr6_-_97179100 0.304 ENSMUST00000095664.3
Tmf1
TATA element modulatory factor 1
chr11_-_120731944 0.298 ENSMUST00000154565.1
ENSMUST00000026148.2
Cbr2

carbonyl reductase 2

chr17_-_46153517 0.286 ENSMUST00000171172.1
Mad2l1bp
MAD2L1 binding protein
chr6_-_113377866 0.284 ENSMUST00000032410.7
Tada3
transcriptional adaptor 3
chr18_+_80253274 0.259 ENSMUST00000131780.1
ENSMUST00000157056.1
Pqlc1

PQ loop repeat containing 1

chr7_-_44997221 0.241 ENSMUST00000152341.1
Bcl2l12
BCL2-like 12 (proline rich)
chr7_+_119896292 0.241 ENSMUST00000106517.1
Lyrm1
LYR motif containing 1
chr13_+_64432479 0.228 ENSMUST00000021939.6
Cdk20
cyclin-dependent kinase 20
chr7_+_120677579 0.221 ENSMUST00000060175.6
BC030336
cDNA sequence BC030336
chr2_+_32395896 0.217 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr7_+_119895836 0.204 ENSMUST00000106518.1
ENSMUST00000054440.3
Lyrm1

LYR motif containing 1

chr8_-_71381907 0.185 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr5_-_142905816 0.175 ENSMUST00000171419.1
Actb
actin, beta
chr7_-_119720742 0.144 ENSMUST00000033236.7
Thumpd1
THUMP domain containing 1
chr5_-_142905928 0.136 ENSMUST00000106216.2
Actb
actin, beta
chr3_-_19311269 0.111 ENSMUST00000099195.3
Pde7a
phosphodiesterase 7A
chr11_-_5898771 0.105 ENSMUST00000102921.3
Myl7
myosin, light polypeptide 7, regulatory
chr3_+_106113229 0.104 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr4_-_122886044 0.051 ENSMUST00000106255.1
ENSMUST00000106257.3
Cap1

CAP, adenylate cyclase-associated protein 1 (yeast)

chr5_-_106696819 0.046 ENSMUST00000127434.1
ENSMUST00000112696.1
ENSMUST00000112698.1
Zfp644


zinc finger protein 644


chr5_-_106696530 0.031 ENSMUST00000137285.1
ENSMUST00000124263.1
ENSMUST00000112695.1
ENSMUST00000155495.1
ENSMUST00000135108.1
Zfp644




zinc finger protein 644




chr2_-_164833438 0.028 ENSMUST00000042775.4
Neurl2
neuralized-like 2 (Drosophila)
chr12_-_110696248 0.015 ENSMUST00000124156.1
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr2_-_91649785 0.011 ENSMUST00000111333.1
Zfp408
zinc finger protein 408

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.2 3.7 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.9 4.3 GO:0030091 protein repair(GO:0030091)
0.7 2.0 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.5 1.5 GO:0007525 somatic muscle development(GO:0007525)
0.4 1.5 GO:0060025 regulation of synaptic activity(GO:0060025)
0.4 1.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.4 1.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 1.0 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.3 2.5 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.2 1.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 0.6 GO:0032714 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-5 production(GO:0032714) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.2 2.2 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.6 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 0.4 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 6.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.5 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.1 0.8 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 0.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 1.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.7 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.1 0.6 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.3 GO:2000834 luteinizing hormone secretion(GO:0032275) androgen secretion(GO:0035935) testosterone secretion(GO:0035936) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.1 0.3 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.6 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.1 0.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.8 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.1 2.9 GO:0045214 sarcomere organization(GO:0045214)
0.1 0.7 GO:0030836 positive regulation of actin filament depolymerization(GO:0030836)
0.1 2.4 GO:0001706 endoderm formation(GO:0001706)
0.1 0.4 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0 0.3 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 1.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.6 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.0 0.2 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.8 GO:0006754 ATP biosynthetic process(GO:0006754)
0.0 0.2 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 3.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.2 GO:0042629 mast cell granule(GO:0042629)
0.1 1.4 GO:0070938 contractile ring(GO:0070938)
0.1 2.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.6 GO:0043034 costamere(GO:0043034)
0.1 0.4 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.3 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 7.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0031672 A band(GO:0031672)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.6 4.3 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.2 1.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.2 0.5 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.1 0.8 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.6 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.6 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 1.5 GO:0017166 vinculin binding(GO:0017166)
0.1 0.3 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 0.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 1.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.4 GO:0002135 CTP binding(GO:0002135)
0.1 12.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 3.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.3 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 6.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)