Motif ID: Srf
Z-value: 1.159
Transcription factors associated with Srf:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Srf | ENSMUSG00000015605.5 | Srf |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Srf | mm10_v2_chr17_-_46556158_46556188 | -0.44 | 3.6e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 13.3 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
1.2 | 3.7 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) |
0.9 | 4.3 | GO:0030091 | protein repair(GO:0030091) |
0.7 | 2.0 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
0.5 | 1.5 | GO:0007525 | somatic muscle development(GO:0007525) |
0.4 | 1.5 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
0.4 | 1.1 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
0.4 | 1.8 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
0.3 | 1.0 | GO:0010512 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) |
0.3 | 2.5 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
0.2 | 1.6 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
0.2 | 0.6 | GO:0032714 | negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-5 production(GO:0032714) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
0.2 | 2.2 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.1 | 0.6 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
0.1 | 0.4 | GO:0045358 | negative regulation of interferon-beta biosynthetic process(GO:0045358) |
0.1 | 6.6 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
0.1 | 0.5 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
0.1 | 0.8 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
0.1 | 0.7 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
0.1 | 1.0 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
0.1 | 0.7 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
0.1 | 0.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
0.1 | 0.3 | GO:2000834 | luteinizing hormone secretion(GO:0032275) androgen secretion(GO:0035935) testosterone secretion(GO:0035936) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
0.1 | 0.3 | GO:0006116 | NADH oxidation(GO:0006116) |
0.1 | 0.6 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
0.1 | 0.7 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
0.1 | 0.8 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
0.1 | 2.9 | GO:0045214 | sarcomere organization(GO:0045214) |
0.1 | 0.7 | GO:0030836 | positive regulation of actin filament depolymerization(GO:0030836) |
0.1 | 2.4 | GO:0001706 | endoderm formation(GO:0001706) |
0.1 | 0.4 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
0.0 | 0.3 | GO:0003161 | cardiac conduction system development(GO:0003161) |
0.0 | 1.1 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
0.0 | 0.3 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.0 | 0.3 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
0.0 | 0.3 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
0.0 | 0.6 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
0.0 | 0.6 | GO:0048741 | skeletal muscle fiber development(GO:0048741) |
0.0 | 0.2 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
0.0 | 0.8 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
0.0 | 0.2 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.0 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.4 | 3.7 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.3 | 1.8 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
0.1 | 1.2 | GO:0042629 | mast cell granule(GO:0042629) |
0.1 | 1.4 | GO:0070938 | contractile ring(GO:0070938) |
0.1 | 2.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.1 | 2.6 | GO:0043034 | costamere(GO:0043034) |
0.1 | 0.4 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
0.1 | 0.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.1 | 0.6 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
0.1 | 0.6 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.1 | 1.0 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
0.0 | 1.6 | GO:0090544 | BAF-type complex(GO:0090544) |
0.0 | 0.3 | GO:0070688 | MLL5-L complex(GO:0070688) |
0.0 | 0.8 | GO:0002102 | podosome(GO:0002102) |
0.0 | 7.4 | GO:0000139 | Golgi membrane(GO:0000139) |
0.0 | 0.1 | GO:0031672 | A band(GO:0031672) |
0.0 | 1.0 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 0.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 1.1 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 0.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.5 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
0.6 | 4.3 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.2 | 1.5 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
0.2 | 1.6 | GO:0048495 | Roundabout binding(GO:0048495) |
0.2 | 0.5 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
0.1 | 0.8 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
0.1 | 0.6 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
0.1 | 1.1 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
0.1 | 0.6 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.1 | 1.5 | GO:0017166 | vinculin binding(GO:0017166) |
0.1 | 0.3 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
0.1 | 0.5 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
0.1 | 1.2 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.1 | 1.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.1 | 2.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 0.4 | GO:0002135 | CTP binding(GO:0002135) |
0.1 | 12.6 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
0.1 | 0.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.1 | 0.2 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
0.1 | 3.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.0 | 1.0 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.3 | GO:0030957 | Tat protein binding(GO:0030957) |
0.0 | 0.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.0 | 0.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 1.8 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 0.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.0 | 6.3 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.0 | 2.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.6 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
0.0 | 0.8 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 1.1 | GO:0008013 | beta-catenin binding(GO:0008013) |