Motif ID: Srf

Z-value: 1.159


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_46556188-0.443.6e-02Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 13.256 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_137314394 4.881 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr10_-_120899067 4.273 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr4_+_43957678 3.792 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr1_-_127677923 3.653 ENSMUST00000160616.1
 Tmem163
transmembrane protein 163
chr4_+_43957401 3.603 ENSMUST00000030202.7
 Glipr2
GLI pathogenesis-related 2
chr5_-_24329556 2.545 ENSMUST00000115098.2
 Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr13_+_51846673 2.503 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr4_-_63403330 2.479 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr19_+_53529100 2.437 ENSMUST00000038287.6
 Dusp5
dual specificity phosphatase 5
chr14_+_5071040 2.213 ENSMUST00000163719.1
 Gm8281
predicted gene, 8281
chr14_+_4415448 2.030 ENSMUST00000168866.1
 Gm3164
predicted gene 3164
chr4_+_137862237 2.030 ENSMUST00000102518.3
 Ece1
endothelin converting enzyme 1
chr11_+_94741782 1.736 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr14_-_6038209 1.716 ENSMUST00000164139.1
 Gm8206
predicted gene 8206
chr14_+_3049285 1.673 ENSMUST00000166494.1
 Gm2897
predicted gene 2897
chr14_+_4726775 1.616 ENSMUST00000165619.1
 Gm3252
predicted gene 3252
chr14_-_5961745 1.609 ENSMUST00000163885.1
 Gm3248
predicted gene 3248
chr14_+_3652030 1.567 ENSMUST00000167430.1
 Gm3020
predicted gene 3020
chr14_-_6889962 1.561 ENSMUST00000171906.1
 Gm3667
predicted gene 3667

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 13.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 6.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.9 4.3 GO:0030091 protein repair(GO:0030091)
1.2 3.7 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.1 2.9 GO:0045214 sarcomere organization(GO:0045214)
0.3 2.5 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.1 2.4 GO:0001706 endoderm formation(GO:0001706)
0.2 2.2 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.7 2.0 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.4 1.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 1.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.5 1.5 GO:0007525 somatic muscle development(GO:0007525)
0.4 1.5 GO:0060025 regulation of synaptic activity(GO:0060025)
0.4 1.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 1.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.3 1.0 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.1 1.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.8 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 0.8 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.8 GO:0006754 ATP biosynthetic process(GO:0006754)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0000139 Golgi membrane(GO:0000139)
0.4 3.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 2.6 GO:0043034 costamere(GO:0043034)
0.1 2.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.4 2.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 1.4 GO:0070938 contractile ring(GO:0070938)
0.1 1.2 GO:0042629 mast cell granule(GO:0042629)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 0.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.4 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 0.3 GO:0070688 MLL5-L complex(GO:0070688)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 6.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.6 4.3 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 3.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.8 2.5 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.2 1.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 1.5 GO:0017166 vinculin binding(GO:0017166)
0.1 1.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.8 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.1 0.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0008179 adenylate cyclase binding(GO:0008179)