Motif ID: Stat2

Z-value: 3.203


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.396.4e-02Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_173942445 25.244 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr12_+_103434211 22.046 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr7_-_141010759 18.533 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr4_-_154636831 18.110 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr3_-_107760221 17.536 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr6_+_121245903 16.062 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr1_-_156674290 14.816 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr16_+_42907563 13.390 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr16_-_22439719 13.268 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr14_+_28511344 12.144 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr16_+_43363855 11.869 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr6_-_39118211 11.152 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr19_+_55741810 10.936 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr16_+_43235856 10.642 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr8_-_71537402 10.604 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr11_+_119393060 10.379 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr8_-_84773381 10.178 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr16_+_43364145 10.141 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr2_-_51972990 10.108 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr2_+_4559742 9.127 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 48.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.1 31.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.5 29.2 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
1.8 26.3 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.5 22.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
2.6 18.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
5.9 17.8 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
2.7 16.2 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.1 15.0 GO:0016579 protein deubiquitination(GO:0016579)
1.9 13.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
2.7 13.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
4.0 12.1 GO:1900020 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
1.4 10.9 GO:0048625 myoblast fate commitment(GO:0048625)
2.1 10.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
2.7 10.6 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.3 10.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.6 10.2 GO:0009597 detection of virus(GO:0009597)
0.7 10.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
3.4 10.1 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 9.1 GO:0001919 regulation of receptor recycling(GO:0001919)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 59.6 GO:0005654 nucleoplasm(GO:0005654)
0.0 43.3 GO:0005634 nucleus(GO:0005634)
0.1 38.4 GO:0045177 apical part of cell(GO:0045177)
0.3 26.3 GO:0016363 nuclear matrix(GO:0016363)
0.5 22.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 19.8 GO:0005730 nucleolus(GO:0005730)
0.4 19.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
5.8 17.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 14.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 12.7 GO:0005770 late endosome(GO:0005770)
1.2 10.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 10.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 10.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 10.2 GO:0032587 ruffle membrane(GO:0032587)
0.8 9.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 9.1 GO:0005923 bicellular tight junction(GO:0005923)
0.7 6.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 6.5 GO:0043197 dendritic spine(GO:0043197)
0.5 5.8 GO:0020003 symbiont-containing vacuole(GO:0020003)
1.0 4.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 68.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.0 26.3 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.1 24.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 23.4 GO:0046332 SMAD binding(GO:0046332)
1.1 22.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
1.0 22.0 GO:0005521 lamin binding(GO:0005521)
0.2 17.5 GO:0008083 growth factor activity(GO:0008083)
0.2 17.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 16.3 GO:0005525 GTP binding(GO:0005525)
4.0 16.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.6 16.1 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.2 14.8 GO:0016836 hydro-lyase activity(GO:0016836)
4.0 12.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.5 10.9 GO:0045295 gamma-catenin binding(GO:0045295)
2.7 10.7 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.7 9.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.3 9.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.7 8.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.0 8.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.6 7.9 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)