Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.952

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.511.4e-02Click!
Stat3mm10_v2_chr11_-_100939457_1009394840.453.0e-02Click!
Stat5bmm10_v2_chr11_-_100850724_100850763-0.242.7e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 6.005 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_-_64046925 4.226 ENSMUST00000107377.3
 Tnc
tenascin C
chr7_-_78577771 2.954 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr17_+_26715644 2.755 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr5_+_88886809 2.752 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr7_+_141476374 2.382 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr4_-_108031938 2.231 ENSMUST00000106708.1
 Podn
podocan
chr10_+_128909866 2.193 ENSMUST00000026407.7
 Cd63
CD63 antigen
chr10_-_95417099 2.182 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr16_-_23988852 2.165 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr5_-_34513892 2.113 ENSMUST00000114359.1
ENSMUST00000030991.7
ENSMUST00000087737.3
 Tnip2


TNFAIP3 interacting protein 2


chr4_-_108032069 2.081 ENSMUST00000106709.2
 Podn
podocan
chr10_-_95416850 1.997 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr8_+_25532125 1.939 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr3_-_107760221 1.913 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr8_-_105568298 1.861 ENSMUST00000005849.5
 Agrp
agouti related protein
chr16_-_74411776 1.805 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr4_+_148602527 1.748 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr4_+_11704439 1.722 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr3_-_85741389 1.696 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 4.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
1.1 4.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.7 3.3 GO:2000680 regulation of rubidium ion transport(GO:2000680)
1.1 3.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 3.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.0 3.0 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.6 2.8 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 2.8 GO:0015701 bicarbonate transport(GO:0015701)
0.4 2.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 2.5 GO:0035455 response to interferon-alpha(GO:0035455)
0.7 2.2 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 2.2 GO:0007520 myoblast fusion(GO:0007520)
0.7 2.1 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.6 1.9 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.6 1.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.5 1.9 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.4 1.9 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 1.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.0 GO:0032279 asymmetric synapse(GO:0032279)
0.3 5.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 4.5 GO:0043235 receptor complex(GO:0043235)
0.0 4.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.8 3.3 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 3.2 GO:0030673 axolemma(GO:0030673)
0.1 3.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.5 2.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.9 GO:0016604 nuclear body(GO:0016604)
0.0 2.8 GO:0072562 blood microparticle(GO:0072562)
0.0 2.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.4 GO:0016607 nuclear speck(GO:0016607)
0.6 1.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 1.7 GO:0051233 spindle midzone(GO:0051233)
0.1 1.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.5 1.5 GO:0035061 interchromatin granule(GO:0035061)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.9 4.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.7 4.2 GO:0045545 syndecan binding(GO:0045545)
0.1 3.6 GO:0005518 collagen binding(GO:0005518)
0.4 3.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 3.2 GO:0005096 GTPase activator activity(GO:0005096)
0.6 3.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.9 2.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 2.7 GO:0003823 antigen binding(GO:0003823)
0.5 2.5 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 2.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 2.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.0 GO:0017091 AU-rich element binding(GO:0017091)
0.0 2.0 GO:0002039 p53 binding(GO:0002039)
0.2 1.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 1.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.4 1.6 GO:0019962 interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962) interleukin-20 binding(GO:0042015)
0.1 1.6 GO:0001846 opsonin binding(GO:0001846)
0.0 1.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)