Motif ID: Stat6

Z-value: 0.671


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_127643034-0.331.2e-01Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 4.262 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_21989475 4.054 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr18_+_50053282 2.726 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr1_+_146497614 2.703 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr3_-_86548268 2.475 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr3_+_102010138 2.456 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr17_+_29090969 2.323 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr5_-_106574706 1.940 ENSMUST00000131029.1
ENSMUST00000124394.2
 RP24-421H18.1

RP24-421H18.1

chr1_+_146495621 1.854 ENSMUST00000074622.4
 Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr7_-_70366735 1.610 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr17_-_89910449 1.598 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184
chr9_+_112234257 1.590 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr9_-_70421533 1.417 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr8_-_47990535 1.371 ENSMUST00000057561.7
 Wwc2
WW, C2 and coiled-coil domain containing 2
chr3_+_67892189 1.274 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr2_-_113848655 1.227 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr2_+_163225363 1.158 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr16_-_23890805 1.121 ENSMUST00000004480.3
 Sst
somatostatin
chr2_-_113848601 1.046 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr7_-_126800354 0.988 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.5 4.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.4 4.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.0 2.7 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.1 2.5 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 2.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.3 2.3 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.3 1.6 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.2 1.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 1.5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.3 1.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 1.4 GO:0043029 T cell homeostasis(GO:0043029)
0.0 1.1 GO:0095500 synaptic transmission, cholinergic(GO:0007271) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) negative regulation of protein localization to plasma membrane(GO:1903077) signal transduction involved in cellular response to ammonium ion(GO:1903831) negative regulation of protein localization to cell periphery(GO:1904376) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 1.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.1 0.9 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.9 GO:0060384 innervation(GO:0060384)
0.1 0.8 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.1 0.8 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 0.7 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 0.6 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.6 GO:0030891 VCB complex(GO:0030891)
0.1 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.3 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.2 GO:0044299 C-fiber(GO:0044299)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 2.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 1.5 GO:0050699 WW domain binding(GO:0050699)
0.0 1.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 1.1 GO:0005179 hormone activity(GO:0005179)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.7 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 0.6 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.1 0.6 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.6 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.6 GO:0070717 poly-purine tract binding(GO:0070717)
0.1 0.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)