Motif ID: Tbr1

Z-value: 0.970


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.415.2e-02Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_46672537 3.409 ENSMUST00000049298.7
 Tph1
tryptophan hydroxylase 1
chr19_-_57008187 2.523 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr2_+_71528657 2.398 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr1_-_186705980 2.164 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr12_+_85473883 2.103 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr11_-_32222233 2.099 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr9_+_22454290 2.047 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr11_-_69900930 1.975 ENSMUST00000018714.6
ENSMUST00000128046.1
 2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr7_-_19698206 1.798 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr11_-_69900949 1.758 ENSMUST00000102580.3
 2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr14_+_80000292 1.729 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr8_+_45885479 1.589 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr16_-_37384915 1.556 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr11_-_69900886 1.498 ENSMUST00000108621.2
ENSMUST00000100969.2
 2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr1_+_169655493 1.483 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr2_+_71529085 1.409 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr13_-_105271039 1.382 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr10_+_57784859 1.362 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr4_-_154636831 1.305 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr16_-_43979050 1.278 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 4.8 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 4.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.5 3.4 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 3.2 GO:0015701 bicarbonate transport(GO:0015701)
0.1 3.0 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 2.5 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.7 2.2 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1 2.2 GO:0060134 prepulse inhibition(GO:0060134)
0.1 2.1 GO:0035994 response to muscle stretch(GO:0035994)
0.3 1.9 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.6 1.8 GO:0030421 defecation(GO:0030421)
0.6 1.8 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.4 1.8 GO:0015871 choline transport(GO:0015871)
0.1 1.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.3 1.5 GO:0036233 glycine import(GO:0036233)
0.1 1.4 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 1.4 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 1.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.4 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.3 1.3 GO:1901679 nucleotide transmembrane transport(GO:1901679)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 4.0 GO:0005604 basement membrane(GO:0005604)
0.0 3.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 2.5 GO:0097441 basilar dendrite(GO:0097441)
0.5 2.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.1 GO:0000124 SAGA complex(GO:0000124)
0.0 2.1 GO:0005770 late endosome(GO:0005770)
0.6 1.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 1.8 GO:0031201 SNARE complex(GO:0031201)
0.1 1.7 GO:0042581 specific granule(GO:0042581)
0.1 1.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.2 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.0 GO:0070652 HAUS complex(GO:0070652)
0.0 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.0 GO:0005814 centriole(GO:0005814)
0.1 0.9 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.1 0.9 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 3.6 GO:0019905 syntaxin binding(GO:0019905)
1.1 3.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 3.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 3.1 GO:0045296 cadherin binding(GO:0045296)
0.3 3.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.5 2.2 GO:0031720 haptoglobin binding(GO:0031720)
0.5 2.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 1.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 1.9 GO:0008083 growth factor activity(GO:0008083)
0.6 1.8 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.5 1.8 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 1.7 GO:1990239 steroid hormone binding(GO:1990239)
0.1 1.6 GO:0008430 selenium binding(GO:0008430)
0.1 1.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.3 1.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.4 GO:0001968 fibronectin binding(GO:0001968)