Motif ID: Tbx1_Eomes
Z-value: 1.070
Transcription factors associated with Tbx1_Eomes:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Eomes | ENSMUSG00000032446.8 | Eomes |
Tbx1 | ENSMUSG00000009097.9 | Tbx1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Eomes | mm10_v2_chr9_+_118478851_118478866 | -0.10 | 6.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 3.4 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
1.7 | 8.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
1.5 | 6.0 | GO:0051866 | general adaptation syndrome(GO:0051866) |
1.2 | 3.7 | GO:0032474 | otolith morphogenesis(GO:0032474) |
1.0 | 4.9 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.8 | 11.0 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.7 | 1.4 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.6 | 1.8 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) |
0.6 | 2.2 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
0.6 | 5.0 | GO:0071493 | cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399) |
0.4 | 4.5 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.4 | 3.4 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
0.4 | 4.8 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.4 | 1.2 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.4 | 1.1 | GO:0090526 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.3 | 1.6 | GO:0030091 | protein repair(GO:0030091) |
0.3 | 0.9 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
0.3 | 1.2 | GO:0007412 | axon target recognition(GO:0007412) |
0.3 | 2.3 | GO:0010587 | miRNA catabolic process(GO:0010587) |
0.3 | 0.8 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
0.3 | 1.3 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
0.2 | 0.7 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643) |
0.2 | 4.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
0.2 | 1.1 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
0.2 | 0.5 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.2 | 0.5 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
0.2 | 4.5 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
0.1 | 0.4 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) |
0.1 | 0.9 | GO:1900116 | sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
0.1 | 3.2 | GO:0007340 | acrosome reaction(GO:0007340) |
0.1 | 17.0 | GO:0050807 | regulation of synapse organization(GO:0050807) |
0.1 | 0.4 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
0.1 | 0.4 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
0.1 | 0.7 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.1 | 1.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
0.1 | 1.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.1 | 0.4 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
0.1 | 0.2 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
0.1 | 0.1 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
0.1 | 1.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.1 | 0.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
0.1 | 0.6 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
0.1 | 0.3 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
0.1 | 0.3 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
0.1 | 1.1 | GO:1903861 | regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861) |
0.1 | 0.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.1 | 0.2 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.1 | 0.8 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
0.1 | 0.2 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
0.1 | 0.2 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) peptidyl-arginine omega-N-methylation(GO:0035247) |
0.1 | 0.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.0 | 0.2 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
0.0 | 0.5 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.0 | 0.1 | GO:0034287 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) |
0.0 | 0.3 | GO:0036506 | maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.0 | 0.6 | GO:0016926 | protein desumoylation(GO:0016926) |
0.0 | 0.1 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
0.0 | 0.3 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.0 | 0.3 | GO:0071384 | cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385) |
0.0 | 0.2 | GO:0007128 | meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764) |
0.0 | 0.5 | GO:0086036 | mitochondrial calcium ion transport(GO:0006851) regulation of cardiac muscle cell membrane potential(GO:0086036) |
0.0 | 0.2 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
0.0 | 0.3 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.0 | 0.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
0.0 | 0.6 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 0.5 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
0.0 | 3.4 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
0.0 | 1.0 | GO:0008347 | glial cell migration(GO:0008347) |
0.0 | 0.3 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.0 | 0.8 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
0.0 | 0.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 0.4 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
0.0 | 0.1 | GO:0046549 | retinal cone cell development(GO:0046549) |
0.0 | 0.1 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
0.0 | 0.2 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
0.0 | 0.8 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
0.0 | 0.0 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 5.0 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
0.3 | 11.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.2 | 7.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.2 | 13.0 | GO:0005581 | collagen trimer(GO:0005581) |
0.2 | 0.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.2 | 0.8 | GO:1990357 | terminal web(GO:1990357) |
0.1 | 3.4 | GO:0001741 | XY body(GO:0001741) |
0.1 | 0.3 | GO:0070765 | gamma-secretase complex(GO:0070765) |
0.1 | 1.1 | GO:0061700 | GATOR2 complex(GO:0061700) |
0.1 | 1.2 | GO:0031045 | dense core granule(GO:0031045) |
0.1 | 1.6 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.1 | 0.3 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.1 | 0.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 0.2 | GO:0070469 | respiratory chain(GO:0070469) |
0.1 | 0.5 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
0.1 | 0.5 | GO:0005916 | fascia adherens(GO:0005916) |
0.0 | 0.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.3 | GO:0005638 | lamin filament(GO:0005638) |
0.0 | 0.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.0 | 0.3 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 3.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 2.3 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 0.2 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.0 | 0.5 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.0 | 0.9 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.4 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
0.0 | 1.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 1.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 0.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 0.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.0 | 0.6 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
0.0 | 1.1 | GO:0031985 | Golgi cisterna(GO:0031985) |
0.0 | 0.1 | GO:0031415 | NatA complex(GO:0031415) |
0.0 | 0.8 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
0.0 | 0.3 | GO:0043034 | costamere(GO:0043034) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 4.5 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
0.5 | 1.4 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
0.5 | 1.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.4 | 3.4 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
0.4 | 1.2 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.4 | 2.2 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
0.3 | 4.8 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
0.3 | 0.9 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
0.3 | 1.3 | GO:0038132 | neuregulin binding(GO:0038132) |
0.3 | 11.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.3 | 3.8 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.2 | 1.6 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.2 | 0.8 | GO:0050436 | microfibril binding(GO:0050436) |
0.2 | 1.1 | GO:0070728 | leucine binding(GO:0070728) |
0.2 | 0.5 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
0.2 | 4.9 | GO:0005112 | Notch binding(GO:0005112) |
0.2 | 0.6 | GO:0042806 | fucose binding(GO:0042806) |
0.1 | 0.7 | GO:0071253 | connexin binding(GO:0071253) |
0.1 | 1.6 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.1 | 0.4 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.1 | 0.9 | GO:0036122 | BMP binding(GO:0036122) |
0.1 | 2.3 | GO:0035198 | miRNA binding(GO:0035198) |
0.1 | 0.5 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.1 | 2.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.1 | 0.4 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.1 | 3.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 1.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.1 | 1.0 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 5.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.1 | 0.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 0.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
0.0 | 0.2 | GO:0035241 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) |
0.0 | 0.2 | GO:0019808 | polyamine binding(GO:0019808) |
0.0 | 0.6 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
0.0 | 0.7 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.0 | 1.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 1.2 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693) |
0.0 | 0.1 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.0 | 0.3 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
0.0 | 1.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
0.0 | 1.1 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.3 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
0.0 | 4.2 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 0.3 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.3 | GO:0005521 | lamin binding(GO:0005521) |
0.0 | 1.1 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.0 | 3.8 | GO:0043774 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) |
0.0 | 0.2 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.2 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.2 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |