Motif ID: Tbx1_Eomes

Z-value: 1.070

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478851_118478866-0.106.5e-01Click!


Activity profile for motif Tbx1_Eomes.

activity profile for motif Tbx1_Eomes


Sorted Z-values histogram for motif Tbx1_Eomes

Sorted Z-values for motif Tbx1_Eomes



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 19.406 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr2_-_13011747 12.696 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr1_+_6730051 10.056 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr1_-_138847579 8.389 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr1_+_6730135 6.831 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr2_-_57114970 5.987 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr17_+_29093763 5.007 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr4_-_35845204 4.956 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr7_-_28302238 4.929 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr6_+_15196949 4.847 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr1_+_132316112 4.524 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr4_+_125490688 4.486 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr9_-_43239816 4.393 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr6_-_94700137 3.675 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr12_+_3891728 3.443 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr6_+_7555053 3.438 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr1_+_153665274 3.275 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr18_-_46212595 3.249 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36
chr1_+_153665666 2.869 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr18_+_60963517 2.813 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 GO:0050807 regulation of synapse organization(GO:0050807)
0.8 11.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.7 8.4 GO:0035262 gonad morphogenesis(GO:0035262)
1.5 6.0 GO:0051866 general adaptation syndrome(GO:0051866)
0.6 5.0 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
1.0 4.9 GO:0007386 compartment pattern specification(GO:0007386)
0.4 4.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 4.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 4.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 4.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.2 3.7 GO:0032474 otolith morphogenesis(GO:0032474)
1.7 3.4 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.4 3.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 3.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 3.2 GO:0007340 acrosome reaction(GO:0007340)
0.3 2.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.6 2.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.6 1.8 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.3 1.6 GO:0030091 protein repair(GO:0030091)
0.7 1.4 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.0 GO:0005581 collagen trimer(GO:0005581)
0.3 11.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 7.3 GO:0032839 dendrite cytoplasm(GO:0032839)
1.7 5.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 3.4 GO:0001741 XY body(GO:0001741)
0.0 3.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.1 1.1 GO:0061700 GATOR2 complex(GO:0061700)
0.0 1.1 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 0.8 GO:1990357 terminal web(GO:1990357)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 5.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 4.9 GO:0005112 Notch binding(GO:0005112)
0.3 4.8 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.9 4.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 4.2 GO:0000287 magnesium ion binding(GO:0000287)
0.3 3.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 3.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.4 3.4 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.3 GO:0035198 miRNA binding(GO:0035198)
0.4 2.2 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 1.6 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 1.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.5 1.4 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.5 1.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 1.3 GO:0038132 neuregulin binding(GO:0038132)
0.4 1.2 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.2 GO:0005540 hyaluronic acid binding(GO:0005540)