Motif ID: Tbx2

Z-value: 0.498


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.621.5e-03Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 4.163 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_138847579 3.052 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr14_+_68083853 1.750 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr7_-_137314394 1.270 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr1_+_132316112 1.269 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr15_+_61987034 1.157 ENSMUST00000159338.1
 Myc
myelocytomatosis oncogene
chr9_-_43239816 1.090 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr10_-_120899067 1.035 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr3_+_102734496 0.971 ENSMUST00000029451.5
 Tspan2
tetraspanin 2
chr5_-_5514730 0.802 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr6_+_15196949 0.779 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr6_+_50110837 0.764 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr1_-_52500679 0.762 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr5_-_5514873 0.754 ENSMUST00000060947.7
 Cldn12
claudin 12
chr3_-_158562199 0.748 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chrX_-_53269020 0.729 ENSMUST00000114838.1
 Fam122b
family with sequence similarity 122, member B
chr7_-_28302238 0.717 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr6_-_94700137 0.662 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr1_-_172329261 0.660 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr5_+_108065742 0.585 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
 Mtf2


metal response element binding transcription factor 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.6 1.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 1.2 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.2 1.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 1.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 1.0 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 1.0 GO:0030091 protein repair(GO:0030091)
0.1 0.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.8 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 0.7 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.7 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.1 0.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.5 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 0.4 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.4 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 0.4 GO:0060467 negative regulation of fertilization(GO:0060467)
0.0 0.4 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.8 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 1.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.7 GO:0043194 axon initial segment(GO:0043194)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0002141 stereocilia ankle link(GO:0002141)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.0 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.1 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)