Motif ID: Tbx4

Z-value: 1.109


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 19.017 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_138847579 9.349 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_-_13011747 8.645 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr1_+_6730051 8.390 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr17_+_29093763 7.416 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr19_+_20601958 6.647 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr6_+_7555053 6.495 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr6_+_15196949 5.553 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr1_+_6730135 4.854 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr4_-_134018829 4.625 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr7_-_28302238 4.250 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr9_-_43239816 4.215 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr18_-_46212595 3.978 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36
chr2_+_164562579 3.777 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr2_-_57114970 3.577 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr12_+_3891728 3.282 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr13_-_89742490 2.888 ENSMUST00000109546.2
 Vcan
versican
chr1_+_153665666 2.819 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_153665274 2.728 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr10_-_120899067 2.719 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.9 9.3 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 8.8 GO:0050807 regulation of synapse organization(GO:0050807)
0.8 7.4 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
1.7 6.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
2.2 6.5 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.5 5.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 5.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.5 4.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.8 4.2 GO:0007386 compartment pattern specification(GO:0007386)
1.2 3.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 3.5 GO:0007340 acrosome reaction(GO:0007340)
0.4 3.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 2.9 GO:0008347 glial cell migration(GO:0008347)
0.5 2.7 GO:0030091 protein repair(GO:0030091)
0.9 2.6 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 2.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 2.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 2.3 GO:0030282 bone mineralization(GO:0030282)
0.7 2.1 GO:0097623 potassium ion export across plasma membrane(GO:0097623)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 9.2 GO:0005581 collagen trimer(GO:0005581)
2.5 7.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 4.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 4.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 3.3 GO:0001741 XY body(GO:0001741)
0.0 2.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 2.1 GO:0042629 mast cell granule(GO:0042629)
0.0 2.0 GO:0031985 Golgi cisterna(GO:0031985)
0.3 1.4 GO:1990357 terminal web(GO:1990357)
0.1 1.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.2 GO:0031415 NatA complex(GO:0031415)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.1 0.6 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.5 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.2 GO:0008270 zinc ion binding(GO:0008270)
0.3 9.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 8.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.5 7.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.1 6.6 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 5.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 4.6 GO:0035198 miRNA binding(GO:0035198)
0.1 4.2 GO:0005112 Notch binding(GO:0005112)
0.1 3.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 3.3 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.2 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 2.7 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 2.6 GO:0000287 magnesium ion binding(GO:0000287)
0.1 2.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 2.3 GO:0097110 scaffold protein binding(GO:0097110)
0.6 1.8 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 1.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.4 GO:0046790 virion binding(GO:0046790)