Motif ID: Tcf21_Msc

Z-value: 1.387

Transcription factors associated with Tcf21_Msc:

Gene SymbolEntrez IDGene Name
Msc ENSMUSG00000025930.5 Msc
Tcf21 ENSMUSG00000045680.7 Tcf21



Activity profile for motif Tcf21_Msc.

activity profile for motif Tcf21_Msc


Sorted Z-values histogram for motif Tcf21_Msc

Sorted Z-values for motif Tcf21_Msc



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf21_Msc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893077 10.028 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_48045144 9.369 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_+_144892813 6.585 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr9_-_40346290 6.566 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr7_+_122289297 6.276 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr2_-_162661075 4.775 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr4_+_144893127 4.697 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_119814495 4.228 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr3_-_84305385 4.112 ENSMUST00000122849.1
ENSMUST00000132283.1
 Trim2

tripartite motif-containing 2

chr5_-_28210022 4.074 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr10_-_18743691 4.002 ENSMUST00000019999.5
 D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chr8_-_122432924 3.996 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr16_+_43510267 3.991 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr7_-_120202104 3.987 ENSMUST00000033198.5
 Crym
crystallin, mu
chr3_+_90537242 3.966 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr1_-_14310198 3.952 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr6_-_54566484 3.740 ENSMUST00000019268.4
 Scrn1
secernin 1
chr4_-_87806276 3.620 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_+_90537306 3.521 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr6_+_80018877 3.453 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 21.3 GO:0042572 retinol metabolic process(GO:0042572)
3.1 9.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 8.2 GO:0051592 response to calcium ion(GO:0051592)
0.7 7.0 GO:0007379 segment specification(GO:0007379)
0.4 6.6 GO:1901629 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of presynaptic membrane organization(GO:1901629)
1.0 6.3 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.7 4.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.3 4.0 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
1.0 4.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 4.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 3.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 3.8 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 3.8 GO:0007520 myoblast fusion(GO:0007520)
0.0 3.8 GO:0007030 Golgi organization(GO:0007030)
0.7 3.4 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.4 3.4 GO:0009404 toxin metabolic process(GO:0009404)
0.4 3.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.6 3.1 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.2 2.9 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.2 2.8 GO:0060363 cranial suture morphogenesis(GO:0060363)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 9.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 8.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 8.2 GO:0031012 extracellular matrix(GO:0031012)
0.1 6.9 GO:0031526 brush border membrane(GO:0031526)
0.0 5.2 GO:0005794 Golgi apparatus(GO:0005794)
1.0 4.0 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 3.4 GO:0005605 basal lamina(GO:0005605)
0.0 3.0 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.9 GO:0030667 secretory granule membrane(GO:0030667)
0.4 2.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 2.7 GO:0030175 filopodium(GO:0030175)
0.1 2.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 2.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.7 2.2 GO:0071438 integrin alpha3-beta1 complex(GO:0034667) invadopodium membrane(GO:0071438)
0.0 2.0 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 1.9 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.8 GO:0000138 Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 21.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.6 9.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 6.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 6.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 6.3 GO:0035184 histone threonine kinase activity(GO:0035184)
0.4 4.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 4.6 GO:0050840 extracellular matrix binding(GO:0050840)
1.0 4.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.5 4.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 4.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 3.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 3.7 GO:0016805 dipeptidase activity(GO:0016805)
0.0 3.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 3.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.7 3.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 3.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.0 3.1 GO:0005534 galactose binding(GO:0005534)
0.1 2.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 2.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.4 GO:0001540 beta-amyloid binding(GO:0001540)