Motif ID: Tcf3

Z-value: 0.560


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80421847_80421876-0.184.2e-01Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_28302238 2.324 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr12_+_109459843 1.665 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_-_72235559 1.437 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr8_-_122699066 1.267 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr12_-_40038025 1.034 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A
chr18_+_60963517 0.974 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr6_+_47244359 0.931 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr8_+_105518736 0.841 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr4_+_128883549 0.794 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr13_-_111808938 0.786 ENSMUST00000109267.2
 Map3k1
mitogen-activated protein kinase kinase kinase 1
chr10_+_123264076 0.756 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr10_-_109010955 0.755 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr3_-_116253467 0.753 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr15_+_34238026 0.751 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr6_+_104492790 0.736 ENSMUST00000161446.1
ENSMUST00000161070.1
ENSMUST00000089215.5
 Cntn6


contactin 6


chr9_-_39604124 0.731 ENSMUST00000042485.4
ENSMUST00000141370.1
 AW551984

expressed sequence AW551984

chr13_+_24638636 0.731 ENSMUST00000110384.2
ENSMUST00000058009.9
ENSMUST00000038477.6
 Fam65b


family with sequence similarity 65, member B


chr19_+_5068077 0.689 ENSMUST00000070630.6
 Cd248
CD248 antigen, endosialin
chr2_-_181043540 0.689 ENSMUST00000124400.1
 Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
chr2_-_170406501 0.667 ENSMUST00000154650.1
 Bcas1
breast carcinoma amplified sequence 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.3 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 1.3 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 1.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 1.3 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 1.2 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.1 1.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 1.1 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 1.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 1.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 0.9 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.2 0.9 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)
0.0 0.9 GO:0035329 hippo signaling(GO:0035329)
0.2 0.8 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.8 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.2 0.7 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
0.2 0.7 GO:0046836 glycolipid transport(GO:0046836)
0.1 0.7 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.1 0.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.0 GO:0009986 cell surface(GO:0009986)
0.2 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.6 GO:0045179 apical cortex(GO:0045179)
0.1 0.6 GO:0005883 neurofilament(GO:0005883)
0.0 0.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.5 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0005112 Notch binding(GO:0005112)
0.0 2.2 GO:0070888 E-box binding(GO:0070888)
0.1 1.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 1.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.9 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.8 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.8 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 0.7 GO:0017089 glycolipid transporter activity(GO:0017089)
0.1 0.7 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.7 GO:0005272 sodium channel activity(GO:0005272)
0.0 0.7 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.6 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)