Motif ID: Tcf4_Mesp1

Z-value: 1.028

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69346143_693462030.164.6e-01Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 5.118 ENSMUST00000164163.1
 Sla
src-like adaptor
chr12_+_82616885 2.942 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr13_-_57907587 2.625 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr11_-_67922136 2.280 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr4_+_125490688 2.226 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr5_+_37028329 2.164 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr7_+_121707189 2.091 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr11_-_7213897 2.066 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr5_+_98854434 1.889 ENSMUST00000031278.4
 Bmp3
bone morphogenetic protein 3
chr7_-_80401707 1.620 ENSMUST00000120753.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr9_-_29411736 1.595 ENSMUST00000115236.1
 Ntm
neurotrimin
chr14_+_101729907 1.587 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr8_-_4217459 1.583 ENSMUST00000176227.1
 BC068157
cDNA sequence BC068157
chr19_-_57314896 1.567 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr5_+_117413977 1.561 ENSMUST00000180430.1
 Ksr2
kinase suppressor of ras 2
chr16_+_13256481 1.407 ENSMUST00000009713.7
ENSMUST00000115809.1
 Mkl2

MKL/myocardin-like 2

chr14_+_101840602 1.401 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 1.368 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chrY_+_897782 1.332 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr9_+_107935876 1.301 ENSMUST00000035700.8
 Camkv
CaM kinase-like vesicle-associated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 508 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.1 2.7 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.2 2.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.5 2.2 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.1 2.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 2.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.4 2.0 GO:0032902 nerve growth factor production(GO:0032902)
0.2 2.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 2.0 GO:0016579 protein deubiquitination(GO:0016579)
0.2 1.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 1.9 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 1.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 1.6 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 1.6 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.4 1.5 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 1.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 1.5 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 1.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 1.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 1.5 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 7.8 GO:0060076 excitatory synapse(GO:0060076)
0.0 5.4 GO:0005768 endosome(GO:0005768)
0.0 3.7 GO:0005912 adherens junction(GO:0005912)
0.1 3.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.7 GO:0033268 node of Ranvier(GO:0033268)
0.0 2.7 GO:0070382 exocytic vesicle(GO:0070382)
0.1 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.5 2.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1 2.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.8 GO:0097060 synaptic membrane(GO:0097060)
0.2 1.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.7 GO:0043196 varicosity(GO:0043196)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.3 1.5 GO:0016011 dystroglycan complex(GO:0016011)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 292 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 GO:0042805 actinin binding(GO:0042805)
0.1 4.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 3.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 3.1 GO:0050811 GABA receptor binding(GO:0050811)
0.3 2.7 GO:0070700 BMP receptor binding(GO:0070700)
0.3 2.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.4 GO:0015485 cholesterol binding(GO:0015485)
0.2 2.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.4 2.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 2.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 2.1 GO:0045499 chemorepellent activity(GO:0045499)
0.4 2.0 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 2.0 GO:0030552 cAMP binding(GO:0030552)
0.1 1.9 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 1.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.5 1.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 1.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)