Motif ID: Tcf7_Tcf7l2

Z-value: 0.911

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l2mm10_v2_chr19_+_55894508_558945340.341.1e-01Click!
Tcf7mm10_v2_chr11_-_52282564_52282579-0.232.8e-01Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_96719549 2.009 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38
chr10_-_116972609 1.972 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr2_+_102706356 1.514 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chrX_+_101532734 1.480 ENSMUST00000118878.1
ENSMUST00000101341.2
ENSMUST00000149274.1
 Taf1


TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor


chr17_+_21690766 1.372 ENSMUST00000097384.1
 Gm10509
predicted gene 10509
chr18_+_10725651 1.307 ENSMUST00000165555.1
 Mib1
mindbomb homolog 1 (Drosophila)
chr3_+_76074270 1.271 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr1_+_132008285 1.252 ENSMUST00000146432.1
 Elk4
ELK4, member of ETS oncogene family
chr12_-_41485751 0.997 ENSMUST00000043884.4
 Lrrn3
leucine rich repeat protein 3, neuronal
chr2_+_153031852 0.914 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr12_+_52699297 0.914 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr5_+_138085083 0.881 ENSMUST00000019660.4
ENSMUST00000066617.5
ENSMUST00000110963.1
 Zkscan1


zinc finger with KRAB and SCAN domains 1


chr7_-_28008416 0.835 ENSMUST00000180024.1
 Zfp850
zinc finger protein 850
chr14_+_21750525 0.834 ENSMUST00000022292.3
 Samd8
sterile alpha motif domain containing 8
chr11_+_108921648 0.826 ENSMUST00000144511.1
 Axin2
axin2
chr7_-_42706369 0.820 ENSMUST00000180131.1
 Gm17067
predicted gene 17067
chr1_-_64121389 0.798 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr9_-_96719404 0.796 ENSMUST00000140121.1
 Zbtb38
zinc finger and BTB domain containing 38
chr1_+_128244122 0.784 ENSMUST00000027592.3
 Ubxn4
UBX domain protein 4
chr1_-_105659008 0.766 ENSMUST00000070699.8
 Pign
phosphatidylinositol glycan anchor biosynthesis, class N

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0006275 regulation of DNA replication(GO:0006275)
0.2 1.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.7 GO:0001947 heart looping(GO:0001947)
0.3 1.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.3 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 1.3 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.3 1.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 0.9 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.9 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.8 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.8 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 0.7 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.7 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.6 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.1 0.6 GO:0003383 apical constriction(GO:0003383)
0.1 0.6 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.6 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.1 0.5 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0072562 blood microparticle(GO:0072562)
0.1 1.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.6 GO:0045120 pronucleus(GO:0045120)
0.1 1.5 GO:0030673 axolemma(GO:0030673)
0.1 1.3 GO:0010369 chromocenter(GO:0010369)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.8 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 0.6 GO:0071914 prominosome(GO:0071914)
0.1 0.6 GO:0033269 internode region of axon(GO:0033269)
0.1 0.5 GO:0030478 actin cap(GO:0030478)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.4 GO:0044307 dendritic branch(GO:0044307)
0.1 0.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.4 GO:0070695 FHF complex(GO:0070695)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.4 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.9 GO:0043495 protein anchor(GO:0043495)
0.1 0.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 0.8 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.2 0.8 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.0 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.6 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.5 GO:0004457 lactate dehydrogenase activity(GO:0004457)