Motif ID: Tcf7l1

Z-value: 1.021


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.203.6e-01Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_108921648 3.410 ENSMUST00000144511.1
 Axin2
axin2
chr11_+_108920800 2.712 ENSMUST00000140821.1
 Axin2
axin2
chr17_+_3326552 2.468 ENSMUST00000169838.1
 Tiam2
T cell lymphoma invasion and metastasis 2
chr2_+_153031852 2.294 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr5_-_148392810 1.747 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_85205120 1.659 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr14_+_101729907 1.609 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr13_-_54687644 1.531 ENSMUST00000129881.1
 Rnf44
ring finger protein 44
chr16_-_34513944 1.526 ENSMUST00000151491.1
ENSMUST00000114960.2
 Kalrn

kalirin, RhoGEF kinase

chr7_+_49246131 1.428 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chrX_-_143933089 1.406 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_183147461 1.395 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr2_-_65529275 1.393 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr16_-_34514084 1.388 ENSMUST00000089655.5
 Kalrn
kalirin, RhoGEF kinase
chr1_+_158362330 1.381 ENSMUST00000170718.1
 Astn1
astrotactin 1
chr1_-_64122256 1.369 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr5_+_44100442 1.358 ENSMUST00000072800.4
 Gm16401
predicted gene 16401
chr14_+_101840501 1.319 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr10_+_80300997 1.303 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr9_+_35423582 1.296 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 6.5 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.4 2.9 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.2 2.6 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.1 2.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 2.1 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.1 2.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 2.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.0 GO:0048813 dendrite morphogenesis(GO:0048813)
0.3 1.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.3 1.7 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.4 1.4 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 1.4 GO:0060539 diaphragm development(GO:0060539)
0.3 1.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.2 1.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 1.3 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.2 1.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 1.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 1.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 1.1 GO:0007614 short-term memory(GO:0007614)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 3.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.9 GO:0005923 bicellular tight junction(GO:0005923)
0.2 1.5 GO:0001739 sex chromatin(GO:0001739)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.3 1.3 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 1.2 GO:0000922 spindle pole(GO:0000922)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.1 1.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 0.8 GO:0001533 cornified envelope(GO:0001533)
0.1 0.8 GO:0070578 RISC-loading complex(GO:0070578)
0.1 0.8 GO:0005638 lamin filament(GO:0005638)
0.0 0.8 GO:0071564 npBAF complex(GO:0071564)
0.2 0.7 GO:1990032 parallel fiber(GO:1990032)
0.1 0.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0070411 I-SMAD binding(GO:0070411)
0.0 5.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.2 GO:0042805 actinin binding(GO:0042805)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.7 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1 1.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.6 GO:0008201 heparin binding(GO:0008201)
0.2 1.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 1.1 GO:0034711 inhibin binding(GO:0034711)
0.1 1.1 GO:0015197 peptide transporter activity(GO:0015197)
0.1 1.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.0 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.8 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.8 GO:0035198 miRNA binding(GO:0035198)
0.0 0.8 GO:0005521 lamin binding(GO:0005521)
0.0 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)