Motif ID: Tead3_Tead4

Z-value: 1.486

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350747_283508200.482.1e-02Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_3397189 8.150 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr1_+_43730593 6.721 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr10_+_28074813 6.369 ENSMUST00000166468.1
 Ptprk
protein tyrosine phosphatase, receptor type, K
chr10_+_24595434 5.800 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr4_-_43558386 5.585 ENSMUST00000130353.1
 Tln1
talin 1
chr10_+_24595623 5.321 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr11_-_100970887 5.161 ENSMUST00000060792.5
 Ptrf
polymerase I and transcript release factor
chr5_+_66968416 4.287 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr6_+_121300227 4.218 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr5_+_66968559 3.676 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr15_+_6386598 3.643 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr7_-_120202104 3.425 ENSMUST00000033198.5
 Crym
crystallin, mu
chr7_-_132813799 3.332 ENSMUST00000097998.2
 Fam53b
family with sequence similarity 53, member B
chr4_+_48045144 3.309 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr9_+_50752758 3.135 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr7_-_132813715 3.117 ENSMUST00000134946.1
 Fam53b
family with sequence similarity 53, member B
chr9_+_69454066 3.086 ENSMUST00000134907.1
 Anxa2
annexin A2
chr8_-_105966038 2.851 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr7_-_19698206 2.674 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr2_+_19658055 2.567 ENSMUST00000052168.4
 Otud1
OTU domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 8.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.8 6.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.6 6.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.7 5.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.9 5.2 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.7 5.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363)
0.2 4.9 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 4.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 4.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.6 4.2 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
1.3 4.0 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.7 3.6 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.7 3.4 GO:0070327 thyroid hormone transport(GO:0070327)
1.1 3.3 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 3.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 3.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 3.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 3.0 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 3.0 GO:0006813 potassium ion transport(GO:0006813)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 10.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 9.3 GO:0005901 caveola(GO:0005901)
0.0 8.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.9 GO:0001726 ruffle(GO:0001726)
1.7 5.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 4.3 GO:0001750 photoreceptor outer segment(GO:0001750)
1.4 4.1 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
1.3 4.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.9 3.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 3.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.0 3.1 GO:0097512 cardiac myofibril(GO:0097512)
0.2 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.2 2.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.4 GO:0000139 Golgi membrane(GO:0000139)
0.2 2.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 2.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 7.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 6.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.6 5.6 GO:0030274 LIM domain binding(GO:0030274)
1.3 5.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.9 5.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
1.4 4.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.2 4.2 GO:0001221 transcription cofactor binding(GO:0001221)
1.3 4.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.4 3.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.4 3.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 3.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 3.3 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.3 3.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 3.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.5 2.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 2.8 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.8 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.5 2.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 2.5 GO:0008420 CTD phosphatase activity(GO:0008420)